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Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient

Standard

Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient. / Geyer, M; Wilpert, J; Wiech, T; Theilacker, C; Stubanus, M; Kramer-Zucker, A; Fischer, K-G; Drognitz, O; Frydrychowicz, A; Kern, W; Walz, G; Pisarski, P.

in: TRANSPL INFECT DIS, Jahrgang 13, Nr. 3, 01.06.2011, S. 278-84.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Geyer, M, Wilpert, J, Wiech, T, Theilacker, C, Stubanus, M, Kramer-Zucker, A, Fischer, K-G, Drognitz, O, Frydrychowicz, A, Kern, W, Walz, G & Pisarski, P 2011, 'Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient', TRANSPL INFECT DIS, Jg. 13, Nr. 3, S. 278-84. https://doi.org/10.1111/j.1399-3062.2010.00583.x

APA

Geyer, M., Wilpert, J., Wiech, T., Theilacker, C., Stubanus, M., Kramer-Zucker, A., Fischer, K-G., Drognitz, O., Frydrychowicz, A., Kern, W., Walz, G., & Pisarski, P. (2011). Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient. TRANSPL INFECT DIS, 13(3), 278-84. https://doi.org/10.1111/j.1399-3062.2010.00583.x

Vancouver

Geyer M, Wilpert J, Wiech T, Theilacker C, Stubanus M, Kramer-Zucker A et al. Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient. TRANSPL INFECT DIS. 2011 Jun 1;13(3):278-84. https://doi.org/10.1111/j.1399-3062.2010.00583.x

Bibtex

@article{5093f1d7f69b443c88e8246f2dce253b,
title = "Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient",
abstract = "We report on the case of an ABO-incompatible renal re-transplant recipient maintained on an intensified immunosuppressive regimen for recurrent cellular rejection episodes and transplant glomerulopathy who presented with rapidly growing hepatic tumors, radiologically suggestive of hemangiosarcoma. Upon resection and pathological work-up, the lesions revealed alveolar echinococcosis, a rare but potentially life-threatening parasitosis. Usually infection with Echinococcus multilocularis remains asymptomatic for extended periods of time and can go unrecognized for years. In the case presented, we observed an atypically rapid growth pattern of E. multilocularis that might have been due to the extent of the immunosuppressive regimen, which included repetitive anti-CD20 treatments. Retrospectively performed serological studies with enzyme-linked immunosorbent assays known to provide high sensitivity and specificity for the detection of echinococcosis in the general population, yielded ambiguous results in our immunocompromised host, which could be, in part, explained by B-cell depletion and its effects on antibody production and indirect actions on cellular immunity. In conclusion, this is the first report to our knowledge of hepatic alveolar echinococcosis in a renal transplant recipient. This case documents an altered clinical course of the parasitosis and the challenge of serological diagnostic tools under an intensified regimen of immunosuppressive agents, including rituximab.",
keywords = "ABO Blood-Group System, Adult, Animals, Antibodies, Monoclonal, Murine-Derived, Antigens, CD20, Blood Group Incompatibility, Disease Progression, Echinococcosis, Hepatic, Echinococcus multilocularis, Female, Humans, Immunosuppressive Agents, Kidney Transplantation, Time Factors",
author = "M Geyer and J Wilpert and T Wiech and C Theilacker and M Stubanus and A Kramer-Zucker and K-G Fischer and O Drognitz and A Frydrychowicz and W Kern and G Walz and P Pisarski",
note = "{\textcopyright} 2010 John Wiley & Sons A/S.",
year = "2011",
month = jun,
day = "1",
doi = "10.1111/j.1399-3062.2010.00583.x",
language = "English",
volume = "13",
pages = "278--84",
journal = "TRANSPL INFECT DIS",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Rapidly progressive hepatic alveolar echinococcosis in an ABO-incompatible renal transplant recipient

AU - Geyer, M

AU - Wilpert, J

AU - Wiech, T

AU - Theilacker, C

AU - Stubanus, M

AU - Kramer-Zucker, A

AU - Fischer, K-G

AU - Drognitz, O

AU - Frydrychowicz, A

AU - Kern, W

AU - Walz, G

AU - Pisarski, P

N1 - © 2010 John Wiley & Sons A/S.

PY - 2011/6/1

Y1 - 2011/6/1

N2 - We report on the case of an ABO-incompatible renal re-transplant recipient maintained on an intensified immunosuppressive regimen for recurrent cellular rejection episodes and transplant glomerulopathy who presented with rapidly growing hepatic tumors, radiologically suggestive of hemangiosarcoma. Upon resection and pathological work-up, the lesions revealed alveolar echinococcosis, a rare but potentially life-threatening parasitosis. Usually infection with Echinococcus multilocularis remains asymptomatic for extended periods of time and can go unrecognized for years. In the case presented, we observed an atypically rapid growth pattern of E. multilocularis that might have been due to the extent of the immunosuppressive regimen, which included repetitive anti-CD20 treatments. Retrospectively performed serological studies with enzyme-linked immunosorbent assays known to provide high sensitivity and specificity for the detection of echinococcosis in the general population, yielded ambiguous results in our immunocompromised host, which could be, in part, explained by B-cell depletion and its effects on antibody production and indirect actions on cellular immunity. In conclusion, this is the first report to our knowledge of hepatic alveolar echinococcosis in a renal transplant recipient. This case documents an altered clinical course of the parasitosis and the challenge of serological diagnostic tools under an intensified regimen of immunosuppressive agents, including rituximab.

AB - We report on the case of an ABO-incompatible renal re-transplant recipient maintained on an intensified immunosuppressive regimen for recurrent cellular rejection episodes and transplant glomerulopathy who presented with rapidly growing hepatic tumors, radiologically suggestive of hemangiosarcoma. Upon resection and pathological work-up, the lesions revealed alveolar echinococcosis, a rare but potentially life-threatening parasitosis. Usually infection with Echinococcus multilocularis remains asymptomatic for extended periods of time and can go unrecognized for years. In the case presented, we observed an atypically rapid growth pattern of E. multilocularis that might have been due to the extent of the immunosuppressive regimen, which included repetitive anti-CD20 treatments. Retrospectively performed serological studies with enzyme-linked immunosorbent assays known to provide high sensitivity and specificity for the detection of echinococcosis in the general population, yielded ambiguous results in our immunocompromised host, which could be, in part, explained by B-cell depletion and its effects on antibody production and indirect actions on cellular immunity. In conclusion, this is the first report to our knowledge of hepatic alveolar echinococcosis in a renal transplant recipient. This case documents an altered clinical course of the parasitosis and the challenge of serological diagnostic tools under an intensified regimen of immunosuppressive agents, including rituximab.

KW - ABO Blood-Group System

KW - Adult

KW - Animals

KW - Antibodies, Monoclonal, Murine-Derived

KW - Antigens, CD20

KW - Blood Group Incompatibility

KW - Disease Progression

KW - Echinococcosis, Hepatic

KW - Echinococcus multilocularis

KW - Female

KW - Humans

KW - Immunosuppressive Agents

KW - Kidney Transplantation

KW - Time Factors

U2 - 10.1111/j.1399-3062.2010.00583.x

DO - 10.1111/j.1399-3062.2010.00583.x

M3 - SCORING: Journal article

C2 - 20977568

VL - 13

SP - 278

EP - 284

JO - TRANSPL INFECT DIS

JF - TRANSPL INFECT DIS

SN - 1398-2273

IS - 3

ER -