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Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

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Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. / Pejoski, David; de Rham, Casimir; Martinez-Murillo, Paola; Santoro, Francesco; Auderset, Floriane; Medaglini, Donata; Pozzi, Gianni; Vono, Maria; Lambert, Paul-Henri; Huttner, Angela; Haks, Mariëlle C; Ottenhoff, Tom H M; Villard, Jean; Siegrist, Claire-Anne; VEBCON.

in: NPJ VACCINES, Jahrgang 5, Nr. 1, 2020, S. 32.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pejoski, D, de Rham, C, Martinez-Murillo, P, Santoro, F, Auderset, F, Medaglini, D, Pozzi, G, Vono, M, Lambert, P-H, Huttner, A, Haks, MC, Ottenhoff, THM, Villard, J, Siegrist, C-A & VEBCON 2020, 'Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination', NPJ VACCINES, Jg. 5, Nr. 1, S. 32. https://doi.org/10.1038/s41541-020-0179-4

APA

Pejoski, D., de Rham, C., Martinez-Murillo, P., Santoro, F., Auderset, F., Medaglini, D., Pozzi, G., Vono, M., Lambert, P-H., Huttner, A., Haks, M. C., Ottenhoff, T. H. M., Villard, J., Siegrist, C-A., & VEBCON (2020). Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ VACCINES, 5(1), 32. https://doi.org/10.1038/s41541-020-0179-4

Vancouver

Pejoski D, de Rham C, Martinez-Murillo P, Santoro F, Auderset F, Medaglini D et al. Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination. NPJ VACCINES. 2020;5(1):32. https://doi.org/10.1038/s41541-020-0179-4

Bibtex

@article{86b347478cca4c8c9b3307e6d6408706,
title = "Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination",
abstract = "The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.",
author = "David Pejoski and {de Rham}, Casimir and Paola Martinez-Murillo and Francesco Santoro and Floriane Auderset and Donata Medaglini and Gianni Pozzi and Maria Vono and Paul-Henri Lambert and Angela Huttner and Haks, {Mari{\"e}lle C} and Ottenhoff, {Tom H M} and Jean Villard and Claire-Anne Siegrist and VEBCON and Addo, {Marylyn Martina}",
note = "{\textcopyright} The Author(s) 2020.",
year = "2020",
doi = "10.1038/s41541-020-0179-4",
language = "English",
volume = "5",
pages = "32",
journal = "NPJ VACCINES",
issn = "2059-0105",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination

AU - Pejoski, David

AU - de Rham, Casimir

AU - Martinez-Murillo, Paola

AU - Santoro, Francesco

AU - Auderset, Floriane

AU - Medaglini, Donata

AU - Pozzi, Gianni

AU - Vono, Maria

AU - Lambert, Paul-Henri

AU - Huttner, Angela

AU - Haks, Mariëlle C

AU - Ottenhoff, Tom H M

AU - Villard, Jean

AU - Siegrist, Claire-Anne

AU - VEBCON

AU - Addo, Marylyn Martina

N1 - © The Author(s) 2020.

PY - 2020

Y1 - 2020

N2 - The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.

AB - The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans.

U2 - 10.1038/s41541-020-0179-4

DO - 10.1038/s41541-020-0179-4

M3 - SCORING: Journal article

C2 - 32337075

VL - 5

SP - 32

JO - NPJ VACCINES

JF - NPJ VACCINES

SN - 2059-0105

IS - 1

ER -