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Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

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Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. / Hausrat, Torben J; Muhia, Mary; Gerrow, Kimberly; Thomas, Philip; Hirdes, Wiebke; Tsukita, Sachiko; Heisler, Frank F; Herich, Lena; Dubroqua, Sylvain; Breiden, Petra; Feldon, Joram; Schwarz, Juergen; Yee, Benjamin K; Smart, Trevor G; Triller, Antoine; Kneussel, Matthias.

in: NAT COMMUN, Jahrgang 6, 2015, S. 6872.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hausrat, TJ, Muhia, M, Gerrow, K, Thomas, P, Hirdes, W, Tsukita, S, Heisler, FF, Herich, L, Dubroqua, S, Breiden, P, Feldon, J, Schwarz, J, Yee, BK, Smart, TG, Triller, A & Kneussel, M 2015, 'Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory', NAT COMMUN, Jg. 6, S. 6872. https://doi.org/10.1038/ncomms7872

APA

Hausrat, T. J., Muhia, M., Gerrow, K., Thomas, P., Hirdes, W., Tsukita, S., Heisler, F. F., Herich, L., Dubroqua, S., Breiden, P., Feldon, J., Schwarz, J., Yee, B. K., Smart, T. G., Triller, A., & Kneussel, M. (2015). Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. NAT COMMUN, 6, 6872. https://doi.org/10.1038/ncomms7872

Vancouver

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S et al. Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory. NAT COMMUN. 2015;6:6872. https://doi.org/10.1038/ncomms7872

Bibtex

@article{cb1cde9a6b6346cca51da489cd3bc117,
title = "Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory",
abstract = "Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic sites. However, the signals that regulate this transition are currently unknown. GABAA receptors containing α5-subunits (GABAAR-α5) concentrate extrasynaptically through radixin (Rdx)-mediated anchorage at the actin cytoskeleton. Here we report a novel mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic receptor density. RhoA/ROCK signalling regulates an activity-dependent Rdx phosphorylation switch that uncouples GABAAR-α5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers. Thus, the unphosphorylated form of Rdx alters mIPSCs. Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phosphorylation in wild-type mice exhibits experience-dependent changes when exposed to novel environments. Our data suggest an additional mode of synaptic plasticity, in which extrasynaptic receptor reservoirs supply synaptic GABAARs.",
author = "Hausrat, {Torben J} and Mary Muhia and Kimberly Gerrow and Philip Thomas and Wiebke Hirdes and Sachiko Tsukita and Heisler, {Frank F} and Lena Herich and Sylvain Dubroqua and Petra Breiden and Joram Feldon and Juergen Schwarz and Yee, {Benjamin K} and Smart, {Trevor G} and Antoine Triller and Matthias Kneussel",
year = "2015",
doi = "10.1038/ncomms7872",
language = "English",
volume = "6",
pages = "6872",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory

AU - Hausrat, Torben J

AU - Muhia, Mary

AU - Gerrow, Kimberly

AU - Thomas, Philip

AU - Hirdes, Wiebke

AU - Tsukita, Sachiko

AU - Heisler, Frank F

AU - Herich, Lena

AU - Dubroqua, Sylvain

AU - Breiden, Petra

AU - Feldon, Joram

AU - Schwarz, Juergen

AU - Yee, Benjamin K

AU - Smart, Trevor G

AU - Triller, Antoine

AU - Kneussel, Matthias

PY - 2015

Y1 - 2015

N2 - Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic sites. However, the signals that regulate this transition are currently unknown. GABAA receptors containing α5-subunits (GABAAR-α5) concentrate extrasynaptically through radixin (Rdx)-mediated anchorage at the actin cytoskeleton. Here we report a novel mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic receptor density. RhoA/ROCK signalling regulates an activity-dependent Rdx phosphorylation switch that uncouples GABAAR-α5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers. Thus, the unphosphorylated form of Rdx alters mIPSCs. Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phosphorylation in wild-type mice exhibits experience-dependent changes when exposed to novel environments. Our data suggest an additional mode of synaptic plasticity, in which extrasynaptic receptor reservoirs supply synaptic GABAARs.

AB - Neurotransmitter receptor density is a major variable in regulating synaptic strength. Receptors rapidly exchange between synapses and intracellular storage pools through endocytic recycling. In addition, lateral diffusion and confinement exchanges surface membrane receptors between synaptic and extrasynaptic sites. However, the signals that regulate this transition are currently unknown. GABAA receptors containing α5-subunits (GABAAR-α5) concentrate extrasynaptically through radixin (Rdx)-mediated anchorage at the actin cytoskeleton. Here we report a novel mechanism that regulates adjustable plasma membrane receptor pools in the control of synaptic receptor density. RhoA/ROCK signalling regulates an activity-dependent Rdx phosphorylation switch that uncouples GABAAR-α5 from its extrasynaptic anchor, thereby enriching synaptic receptor numbers. Thus, the unphosphorylated form of Rdx alters mIPSCs. Rdx gene knockout impairs reversal learning and short-term memory, and Rdx phosphorylation in wild-type mice exhibits experience-dependent changes when exposed to novel environments. Our data suggest an additional mode of synaptic plasticity, in which extrasynaptic receptor reservoirs supply synaptic GABAARs.

U2 - 10.1038/ncomms7872

DO - 10.1038/ncomms7872

M3 - SCORING: Journal article

C2 - 25891999

VL - 6

SP - 6872

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -