PortalPublikationenRadical prostatectomy after previous TUR-P: Oncological, sur...

Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes

Standard

Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes. / Pompe, Raisa S; Leyh-Bannurah, Sami-Ramzi; Preisser, Felix; Salomon, Georg; Graefen, Markus; Huland, Hartwig; Karakiewicz, Pierre I; Tilki, Derya.

in: UROL ONCOL-SEMIN ORI, Jahrgang 36, Nr. 12, 12.2018, S. 527.e21-527.e28.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pompe, RS, Leyh-Bannurah, S-R, Preisser, F, Salomon, G, Graefen, M, Huland, H, Karakiewicz, PI & Tilki, D 2018, 'Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes', UROL ONCOL-SEMIN ORI, Jg. 36, Nr. 12, S. 527.e21-527.e28. https://doi.org/10.1016/j.urolonc.2018.08.010

APA

Pompe, R. S., Leyh-Bannurah, S-R., Preisser, F., Salomon, G., Graefen, M., Huland, H., Karakiewicz, P. I., & Tilki, D. (2018). Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes. UROL ONCOL-SEMIN ORI, 36(12), 527.e21-527.e28. https://doi.org/10.1016/j.urolonc.2018.08.010

Vancouver

Pompe RS, Leyh-Bannurah S-R, Preisser F, Salomon G, Graefen M, Huland H et al. Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes. UROL ONCOL-SEMIN ORI. 2018 Dez;36(12):527.e21-527.e28. https://doi.org/10.1016/j.urolonc.2018.08.010

Bibtex

@article{317060b1ba5f44809684ed946eeffb4f,
title = "Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes",
abstract = "OBJECTIVES: To examine oncological, surgical, and functional outcomes of radical prostatectomy (RP) in patients with history of transurethral resection of the prostate (TUR-P).MATERIALS AND METHODS: Retrospective analysis of 18,681 RP-patients including 470 patients with previous TUR-P at a single institution (2002-2015). Kaplan-Meier as well as multivariable Cox and logistic regression analyses compared surgical, oncological, and functional outcomes between TUR-P and non-TUR-P patients after propensity score matching (nearest neighbor in a 1:3 fashion).RESULTS: After propensity score adjustment, pathological and surgical results were similar between both groups. Specifically, rates of positive surgical margins and nerve-sparing (NS) procedure did not differ between groups (positive surgical margins: 18.5% vs. 17.2%, P = 0.7; nerve-sparing: 89.4% vs. 91.6%, P = 0.5). In addition, there was no difference in mean operating room time (185 vs. 184 minutes, P = 0.6), blood loss (710 vs. 666 ml, P = 0.1), and catheterization time (12 days, P = 0.3). In multivariable analyses, TUR-P patients did not exhibit higher risk of biochemical recurrence, metastatic progression, or mortality (all P > 0.05). However, TUR-P patients exhibited higher risk for urinary incontinence at third month (OR: 1.47; 95% confidence interval [CI] 1.01-2.12, P = 0.04) and first year (OR: 2.06; 95% CI 1.23-3.42, P = 0.006) and worse 1-year erectile function recovery (OR: 0.48; 95% CI 0.27-0.86, P = 0.02).CONCLUSIONS: This large series of TUR-P RP patients demonstrated that RP could be safely performed in patients with history of TUR-P without compromising oncological results. However, functional outcomes were worse for patients with previous TUR-P.",
keywords = "Journal Article",
author = "Pompe, {Raisa S} and Sami-Ramzi Leyh-Bannurah and Felix Preisser and Georg Salomon and Markus Graefen and Hartwig Huland and Karakiewicz, {Pierre I} and Derya Tilki",
note = "Copyright {\textcopyright} 2018. Published by Elsevier Inc.",
year = "2018",
month = dec,
doi = "10.1016/j.urolonc.2018.08.010",
language = "English",
volume = "36",
pages = "527.e21--527.e28",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Radical prostatectomy after previous TUR-P: Oncological, surgical, and functional outcomes

AU - Pompe, Raisa S

AU - Leyh-Bannurah, Sami-Ramzi

AU - Preisser, Felix

AU - Salomon, Georg

AU - Graefen, Markus

AU - Huland, Hartwig

AU - Karakiewicz, Pierre I

AU - Tilki, Derya

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/12

Y1 - 2018/12

N2 - OBJECTIVES: To examine oncological, surgical, and functional outcomes of radical prostatectomy (RP) in patients with history of transurethral resection of the prostate (TUR-P).MATERIALS AND METHODS: Retrospective analysis of 18,681 RP-patients including 470 patients with previous TUR-P at a single institution (2002-2015). Kaplan-Meier as well as multivariable Cox and logistic regression analyses compared surgical, oncological, and functional outcomes between TUR-P and non-TUR-P patients after propensity score matching (nearest neighbor in a 1:3 fashion).RESULTS: After propensity score adjustment, pathological and surgical results were similar between both groups. Specifically, rates of positive surgical margins and nerve-sparing (NS) procedure did not differ between groups (positive surgical margins: 18.5% vs. 17.2%, P = 0.7; nerve-sparing: 89.4% vs. 91.6%, P = 0.5). In addition, there was no difference in mean operating room time (185 vs. 184 minutes, P = 0.6), blood loss (710 vs. 666 ml, P = 0.1), and catheterization time (12 days, P = 0.3). In multivariable analyses, TUR-P patients did not exhibit higher risk of biochemical recurrence, metastatic progression, or mortality (all P > 0.05). However, TUR-P patients exhibited higher risk for urinary incontinence at third month (OR: 1.47; 95% confidence interval [CI] 1.01-2.12, P = 0.04) and first year (OR: 2.06; 95% CI 1.23-3.42, P = 0.006) and worse 1-year erectile function recovery (OR: 0.48; 95% CI 0.27-0.86, P = 0.02).CONCLUSIONS: This large series of TUR-P RP patients demonstrated that RP could be safely performed in patients with history of TUR-P without compromising oncological results. However, functional outcomes were worse for patients with previous TUR-P.

AB - OBJECTIVES: To examine oncological, surgical, and functional outcomes of radical prostatectomy (RP) in patients with history of transurethral resection of the prostate (TUR-P).MATERIALS AND METHODS: Retrospective analysis of 18,681 RP-patients including 470 patients with previous TUR-P at a single institution (2002-2015). Kaplan-Meier as well as multivariable Cox and logistic regression analyses compared surgical, oncological, and functional outcomes between TUR-P and non-TUR-P patients after propensity score matching (nearest neighbor in a 1:3 fashion).RESULTS: After propensity score adjustment, pathological and surgical results were similar between both groups. Specifically, rates of positive surgical margins and nerve-sparing (NS) procedure did not differ between groups (positive surgical margins: 18.5% vs. 17.2%, P = 0.7; nerve-sparing: 89.4% vs. 91.6%, P = 0.5). In addition, there was no difference in mean operating room time (185 vs. 184 minutes, P = 0.6), blood loss (710 vs. 666 ml, P = 0.1), and catheterization time (12 days, P = 0.3). In multivariable analyses, TUR-P patients did not exhibit higher risk of biochemical recurrence, metastatic progression, or mortality (all P > 0.05). However, TUR-P patients exhibited higher risk for urinary incontinence at third month (OR: 1.47; 95% confidence interval [CI] 1.01-2.12, P = 0.04) and first year (OR: 2.06; 95% CI 1.23-3.42, P = 0.006) and worse 1-year erectile function recovery (OR: 0.48; 95% CI 0.27-0.86, P = 0.02).CONCLUSIONS: This large series of TUR-P RP patients demonstrated that RP could be safely performed in patients with history of TUR-P without compromising oncological results. However, functional outcomes were worse for patients with previous TUR-P.

KW - Journal Article

U2 - 10.1016/j.urolonc.2018.08.010

DO - 10.1016/j.urolonc.2018.08.010

M3 - SCORING: Journal article

C2 - 30442538

VL - 36

SP - 527.e21-527.e28

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 12

ER -