Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy

Francesco Chierigo; Rocco Simone Flammia; Gabriele Sorce; Benedikt Hoeh; Lukas Hohenhorst; Andrea Panunzio; Zhe Tian; Fred Saad; Markus Graefen; Michele Gallucci; Alberto Briganti; Francesco Montorsi; Felix K H Chun; Shahrokh F Shariat; Alessandro Antonelli; Giovanni Guano; Guglielmo Mantica; Marco Borghesi; Nazareno Suardi; Carlo Terrone; Pierre I Karakiewicz

doi:10.1080/2090598X.2022.2148867

Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy

Standard

Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy. / Chierigo, Francesco; Flammia, Rocco Simone; Sorce, Gabriele; Hoeh, Benedikt; Hohenhorst, Lukas; Panunzio, Andrea; Tian, Zhe; Saad, Fred; Graefen, Markus; Gallucci, Michele; Briganti, Alberto; Montorsi, Francesco; Chun, Felix K H; Shariat, Shahrokh F; Antonelli, Alessandro; Guano, Giovanni; Mantica, Guglielmo; Borghesi, Marco; Suardi, Nazareno; Terrone, Carlo; Karakiewicz, Pierre I.

in: ARAB J UROL, Jahrgang 21, Nr. 3, 2023, S. 135-141.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Chierigo, F, Flammia, RS, Sorce, G, Hoeh, B, Hohenhorst, L, Panunzio, A, Tian, Z, Saad, F, Graefen, M, Gallucci, M, Briganti, A, Montorsi, F, Chun, FKH, Shariat, SF, Antonelli, A, Guano, G, Mantica, G, Borghesi, M, Suardi, N, Terrone, C & Karakiewicz, PI 2023, 'Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy', ARAB J UROL, Jg. 21, Nr. 3, S. 135-141. https://doi.org/10.1080/2090598X.2022.2148867

APA

Chierigo, F., Flammia, R. S., Sorce, G., Hoeh, B., Hohenhorst, L., Panunzio, A., Tian, Z., Saad, F., Graefen, M., Gallucci, M., Briganti, A., Montorsi, F., Chun, F. K. H., Shariat, S. F., Antonelli, A., Guano, G., Mantica, G., Borghesi, M., Suardi, N., ... Karakiewicz, P. I. (2023). Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy. ARAB J UROL, 21(3), 135-141. https://doi.org/10.1080/2090598X.2022.2148867

Vancouver

Chierigo F, Flammia RS, Sorce G, Hoeh B, Hohenhorst L, Panunzio A et al. Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy. ARAB J UROL. 2023;21(3):135-141. https://doi.org/10.1080/2090598X.2022.2148867

Bibtex

@article{60b70a2ab6ae4807968f0ac1943320e1,

title = "Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy",

abstract = "OBJECTIVE: To assess differences in the distribution of type and number of D'Amico high-risk criteria (DHRCs) according to race/ethnicity (R/E) and their effect on cancer-specific mortality (CSM) in prostate cancer (PCa) patients treated with external beam radiotherapy (RT).METHODS: In the SEER database (2004-2016), we identified 31,002 PCa patients treated with RT with at least one DHRCs, namely PSA >20 ng/dL, biopsy Gleason Grade Group 4-5, and clinical T stage ≥T2c. Competing risks regression (CRR) model tested the association between DHRCs and 5-year CSM in all R/E subgroups.RESULTS: Of 31,002 patients, 20,894 (67%) were Caucasian, 5256 (17%) were African American, 2868 (9.3%) were Hispanic-Latino, and 1984 (6.4%) were Asian. The distributions of individual DHRCs and combinations of two DHRCs differed according to R/E, but not for the combination of three DHRCs. The effect related to the presence of a single DHRC, and combinations of two or three DHRCs on absolute CSM rates was lowest in Asians (1.2-6.8%), followed by in African Americans (2.3-12.2%) and Caucasians (2.3-12.1%), and highest in Hispanic/Latinos (1.7-13.8%). However, the opposite effect was observed in CRR, where hazard ratios were highest in Asians vs. other R/Es: Asians 1.00-2.59 vs. others 0.5-1.83 for one DHRC, Asians 3.4-4.75 vs. others 0.66-3.66 for two DHRCs, and Asians 7.22 vs. others 3.03-4.99 for all three DHRCs.CONCLUSIONS: R/E affects the proportions of DHRCs. Moreover, within the four examined R/E groups, the effect of DHRCs on absolute and relative CSM metrics also differed. Therefore, R/E-specific considerations may be warranted in high-risk PCa patients treated with RT.",

author = "Francesco Chierigo and Flammia, {Rocco Simone} and Gabriele Sorce and Benedikt Hoeh and Lukas Hohenhorst and Andrea Panunzio and Zhe Tian and Fred Saad and Markus Graefen and Michele Gallucci and Alberto Briganti and Francesco Montorsi and Chun, {Felix K H} and Shariat, {Shahrokh F} and Alessandro Antonelli and Giovanni Guano and Guglielmo Mantica and Marco Borghesi and Nazareno Suardi and Carlo Terrone and Karakiewicz, {Pierre I}",

note = "{\textcopyright} 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",

year = "2023",

doi = "10.1080/2090598X.2022.2148867",

language = "English",

volume = "21",

pages = "135--141",

journal = "ARAB J UROL",

issn = "2090-598X",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Racial/ethnic disparities in the distribution and effect of type and number of high-risk criteria on mortality in prostate cancer patients treated with radiotherapy

AU - Chierigo, Francesco

AU - Flammia, Rocco Simone

AU - Sorce, Gabriele

AU - Hoeh, Benedikt

AU - Hohenhorst, Lukas

AU - Panunzio, Andrea

AU - Tian, Zhe

AU - Saad, Fred

AU - Graefen, Markus

AU - Gallucci, Michele

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Chun, Felix K H

AU - Shariat, Shahrokh F

AU - Antonelli, Alessandro

AU - Guano, Giovanni

AU - Mantica, Guglielmo

AU - Borghesi, Marco

AU - Suardi, Nazareno

AU - Terrone, Carlo

AU - Karakiewicz, Pierre I

PY - 2023

Y1 - 2023

N2 - OBJECTIVE: To assess differences in the distribution of type and number of D'Amico high-risk criteria (DHRCs) according to race/ethnicity (R/E) and their effect on cancer-specific mortality (CSM) in prostate cancer (PCa) patients treated with external beam radiotherapy (RT).METHODS: In the SEER database (2004-2016), we identified 31,002 PCa patients treated with RT with at least one DHRCs, namely PSA >20 ng/dL, biopsy Gleason Grade Group 4-5, and clinical T stage ≥T2c. Competing risks regression (CRR) model tested the association between DHRCs and 5-year CSM in all R/E subgroups.RESULTS: Of 31,002 patients, 20,894 (67%) were Caucasian, 5256 (17%) were African American, 2868 (9.3%) were Hispanic-Latino, and 1984 (6.4%) were Asian. The distributions of individual DHRCs and combinations of two DHRCs differed according to R/E, but not for the combination of three DHRCs. The effect related to the presence of a single DHRC, and combinations of two or three DHRCs on absolute CSM rates was lowest in Asians (1.2-6.8%), followed by in African Americans (2.3-12.2%) and Caucasians (2.3-12.1%), and highest in Hispanic/Latinos (1.7-13.8%). However, the opposite effect was observed in CRR, where hazard ratios were highest in Asians vs. other R/Es: Asians 1.00-2.59 vs. others 0.5-1.83 for one DHRC, Asians 3.4-4.75 vs. others 0.66-3.66 for two DHRCs, and Asians 7.22 vs. others 3.03-4.99 for all three DHRCs.CONCLUSIONS: R/E affects the proportions of DHRCs. Moreover, within the four examined R/E groups, the effect of DHRCs on absolute and relative CSM metrics also differed. Therefore, R/E-specific considerations may be warranted in high-risk PCa patients treated with RT.

AB - OBJECTIVE: To assess differences in the distribution of type and number of D'Amico high-risk criteria (DHRCs) according to race/ethnicity (R/E) and their effect on cancer-specific mortality (CSM) in prostate cancer (PCa) patients treated with external beam radiotherapy (RT).METHODS: In the SEER database (2004-2016), we identified 31,002 PCa patients treated with RT with at least one DHRCs, namely PSA >20 ng/dL, biopsy Gleason Grade Group 4-5, and clinical T stage ≥T2c. Competing risks regression (CRR) model tested the association between DHRCs and 5-year CSM in all R/E subgroups.RESULTS: Of 31,002 patients, 20,894 (67%) were Caucasian, 5256 (17%) were African American, 2868 (9.3%) were Hispanic-Latino, and 1984 (6.4%) were Asian. The distributions of individual DHRCs and combinations of two DHRCs differed according to R/E, but not for the combination of three DHRCs. The effect related to the presence of a single DHRC, and combinations of two or three DHRCs on absolute CSM rates was lowest in Asians (1.2-6.8%), followed by in African Americans (2.3-12.2%) and Caucasians (2.3-12.1%), and highest in Hispanic/Latinos (1.7-13.8%). However, the opposite effect was observed in CRR, where hazard ratios were highest in Asians vs. other R/Es: Asians 1.00-2.59 vs. others 0.5-1.83 for one DHRC, Asians 3.4-4.75 vs. others 0.66-3.66 for two DHRCs, and Asians 7.22 vs. others 3.03-4.99 for all three DHRCs.CONCLUSIONS: R/E affects the proportions of DHRCs. Moreover, within the four examined R/E groups, the effect of DHRCs on absolute and relative CSM metrics also differed. Therefore, R/E-specific considerations may be warranted in high-risk PCa patients treated with RT.

U2 - 10.1080/2090598X.2022.2148867

DO - 10.1080/2090598X.2022.2148867

M3 - SCORING: Journal article

C2 - 37521449

VL - 21

SP - 135

EP - 141

JO - ARAB J UROL

JF - ARAB J UROL

SN - 2090-598X

IS - 3

ER -