RABGTPases in MT1-MMP trafficking and cell invasion:Physiology versus pathology
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RABGTPases in MT1-MMP trafficking and cell invasion:Physiology versus pathology. / Linder, Stefan; Scita, Giorgio.
in: Small GTPases, Jahrgang 6, Nr. 3, 03.07.2015, S. 145-52.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - RABGTPases in MT1-MMP trafficking and cell invasion:Physiology versus pathology
AU - Linder, Stefan
AU - Scita, Giorgio
PY - 2015/7/3
Y1 - 2015/7/3
N2 - The matrix metalloproteinase MT1-MMP is a central regulator of cell invasion in both physiological and pathological settings, such as tissue surveillance by immune cells and cancer cell metastasis. MT1-MMP cleaves a plethora of intra- and extracellular proteins, including extracellular matrix proteins, matrix receptors, and also other MMPs, and thus enables modification of both the cell surface proteome and the pericellular environment. Despite its importance for cell invasion, the pathways regulating MT1-MMP exposure on the cell surface are largely unknown. Recently, our groups discovered that a specific subset of RABGTPases, most notably RAB5a, is critical for MT1-MMP trafficking in primary human macrophages and carcinoma cells. Here, we discuss and contrast our findings for both cell types, pointing out common features and differences in the RABGTPase-dependent trafficking of MT1-MMP in health and disease.
AB - The matrix metalloproteinase MT1-MMP is a central regulator of cell invasion in both physiological and pathological settings, such as tissue surveillance by immune cells and cancer cell metastasis. MT1-MMP cleaves a plethora of intra- and extracellular proteins, including extracellular matrix proteins, matrix receptors, and also other MMPs, and thus enables modification of both the cell surface proteome and the pericellular environment. Despite its importance for cell invasion, the pathways regulating MT1-MMP exposure on the cell surface are largely unknown. Recently, our groups discovered that a specific subset of RABGTPases, most notably RAB5a, is critical for MT1-MMP trafficking in primary human macrophages and carcinoma cells. Here, we discuss and contrast our findings for both cell types, pointing out common features and differences in the RABGTPase-dependent trafficking of MT1-MMP in health and disease.
U2 - 10.4161/21541248.2014.985484
DO - 10.4161/21541248.2014.985484
M3 - SCORING: Journal article
C2 - 26107110
VL - 6
SP - 145
EP - 152
JO - Small GTPases
JF - Small GTPases
SN - 2154-1248
IS - 3
ER -
