R0 liver resections for primary malignant liver tumors in the noncirrhotic liver
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R0 liver resections for primary malignant liver tumors in the noncirrhotic liver : a diagnosis-related analysis. / Sotiropoulos, Georgios C; Bockhorn, Maximilian; Sgourakis, George; Brokalaki, Eirini I; Molmenti, Ernesto P; Neuhäuser, Markus; Radtke, Arnold; Wohlschlaeger, Jeremias; Baba, Hideo A; Broelsch, Christoph E; Lang, Hauke.
in: DIGEST DIS SCI, Jahrgang 54, Nr. 4, 01.04.2009, S. 887-94.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - R0 liver resections for primary malignant liver tumors in the noncirrhotic liver
T2 - a diagnosis-related analysis
AU - Sotiropoulos, Georgios C
AU - Bockhorn, Maximilian
AU - Sgourakis, George
AU - Brokalaki, Eirini I
AU - Molmenti, Ernesto P
AU - Neuhäuser, Markus
AU - Radtke, Arnold
AU - Wohlschlaeger, Jeremias
AU - Baba, Hideo A
AU - Broelsch, Christoph E
AU - Lang, Hauke
PY - 2009/4/1
Y1 - 2009/4/1
N2 - BACKGROUND: Primary liver cancer constitutes an increasingly malignancy in the Western world and one of the leading causes of cancer-related deaths worldwide. The purpose of this study was to evaluate and compare long-term outcomes after R0 resections in noncirrhotic livers for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).METHODS: Between April 1998 and May 2006 a total of 102 patients with either ICC (n = 41, group 1) or HCC (n = 61, group 2) in the absence of cirrhosis underwent curative liver resection in our department. Demographic characteristics, operative details, perioperative complications, pathologic findings, tumor recurrence and survival were analyzed.RESULTS: Gender (P = 0.007), extent of liver resection (P = 0.036), additional surgical procedures (P < 0.001) and operative morbidity (P = 0.018) differed among the two groups. Following resection, after a median follow-up of 28 months, the calculated 5-year survival was 44% and 40% for ICC and HCC, respectively (P = 0.38). The corresponding recurrence-free survival was 25% for both ICC and HCC (P = 0.66). UICC stage was found to predict overall and recurrence-free survival in both types of tumors. Multifocality in the case of ICC, and tumor differentiation and vascular invasion in the case of HCC, were predictive factors for overall and recurrence-free survival, respectively. In multivariable analyses, vascular invasion for HCC was predictive for overall and recurrence-free survival, whereas in the case of ICC significant differences were detected in the recurrence analysis for multifocality and UICC stage.CONCLUSIONS: R0 resections for both ICC and HCC result to similar long-term outcomes, which are characterized by good overall and acceptable recurrence-free survival rates.
AB - BACKGROUND: Primary liver cancer constitutes an increasingly malignancy in the Western world and one of the leading causes of cancer-related deaths worldwide. The purpose of this study was to evaluate and compare long-term outcomes after R0 resections in noncirrhotic livers for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC).METHODS: Between April 1998 and May 2006 a total of 102 patients with either ICC (n = 41, group 1) or HCC (n = 61, group 2) in the absence of cirrhosis underwent curative liver resection in our department. Demographic characteristics, operative details, perioperative complications, pathologic findings, tumor recurrence and survival were analyzed.RESULTS: Gender (P = 0.007), extent of liver resection (P = 0.036), additional surgical procedures (P < 0.001) and operative morbidity (P = 0.018) differed among the two groups. Following resection, after a median follow-up of 28 months, the calculated 5-year survival was 44% and 40% for ICC and HCC, respectively (P = 0.38). The corresponding recurrence-free survival was 25% for both ICC and HCC (P = 0.66). UICC stage was found to predict overall and recurrence-free survival in both types of tumors. Multifocality in the case of ICC, and tumor differentiation and vascular invasion in the case of HCC, were predictive factors for overall and recurrence-free survival, respectively. In multivariable analyses, vascular invasion for HCC was predictive for overall and recurrence-free survival, whereas in the case of ICC significant differences were detected in the recurrence analysis for multifocality and UICC stage.CONCLUSIONS: R0 resections for both ICC and HCC result to similar long-term outcomes, which are characterized by good overall and acceptable recurrence-free survival rates.
KW - Aged
KW - Bile Duct Neoplasms
KW - Bile Ducts, Intrahepatic
KW - Carcinoma, Hepatocellular
KW - Cholangiocarcinoma
KW - Disease-Free Survival
KW - Female
KW - Germany
KW - Hepatectomy
KW - Humans
KW - Male
KW - Middle Aged
KW - Monte Carlo Method
KW - Neoplasm Recurrence, Local
KW - Treatment Outcome
U2 - 10.1007/s10620-008-0408-6
DO - 10.1007/s10620-008-0408-6
M3 - SCORING: Journal article
C2 - 18712480
VL - 54
SP - 887
EP - 894
JO - DIGEST DIS SCI
JF - DIGEST DIS SCI
SN - 0163-2116
IS - 4
ER -