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Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model

Standard

Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model. / Gersing, Alexandra S; Faymonville, Andrea M; Schwaiger, Benedikt J; Leypoldt, Frank; Siemonsen, Susanne; Zimmer, Claus; Magnus, Tim; Fiehler, Jens.

in: J NEUROSCI METH, Jahrgang 259, 01.02.2016, S. 83-89.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gersing, AS, Faymonville, AM, Schwaiger, BJ, Leypoldt, F, Siemonsen, S, Zimmer, C, Magnus, T & Fiehler, J 2016, 'Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model', J NEUROSCI METH, Jg. 259, S. 83-89. https://doi.org/10.1016/j.jneumeth.2015.11.018

APA

Gersing, A. S., Faymonville, A. M., Schwaiger, B. J., Leypoldt, F., Siemonsen, S., Zimmer, C., Magnus, T., & Fiehler, J. (2016). Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model. J NEUROSCI METH, 259, 83-89. https://doi.org/10.1016/j.jneumeth.2015.11.018

Vancouver

Gersing AS, Faymonville AM, Schwaiger BJ, Leypoldt F, Siemonsen S, Zimmer C et al. Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model. J NEUROSCI METH. 2016 Feb 1;259:83-89. https://doi.org/10.1016/j.jneumeth.2015.11.018

Bibtex

@article{fcfbd5bdbc11411aa8da748f58552c9e,
title = "Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model",
abstract = "BACKGROUND: Oxyhemoglobin-sensitive sequences, namely T2*, can indirectly depict changes in oxygen extraction. Purpose of this study was to investigate the dynamics of T2* changes in ischemic tissue.NEW METHOD: We investigated earliest temporo-spatial dynamics within ischemic tissue, measured with quantitative T2* imaging in the histologically defined infarct core and surrounding surviving tissue. Middle cerebral artery occlusion (MCAO) was induced by a filament model in mice. Serial multiple gradient-echo T2* sequences and diffusion-weighted images were acquired for 60min after MCAO and repeated for 60min after recanalization. T2* maps were co-registered with histology and T2* changes were compared to the contralateral hemisphere.RESULTS: Within the histologically defined infarct core, relative T2* values decreased significantly by -10.8±2.8% (P=0.003) compared to the contralateral hemisphere within 3.5±0.7min after MCAO. Relative T2* values in volume exceeding the histologically determined infarct core were significantly less decreased (-6.7±2.1%; P=0.02) and increased after recanalization (+3.9±1.9%; P=0.045). Volume with T2* decrease showed continuous growth over 60min after MCAO (P=0.002) and decreased during 60min after recanalization (P=0.026), showing most significant correlations between infarct core volume and T2* abnormality volume (r=0.66; P=0.037) of the last image acquired after recanalization.COMPARISON WITH EXISTING METHOD(S): To our best knowledge, this is the first application of non-invasive quantitative T2* measurements to assess changes in levels of deoxyhemoglobin as an indirect biomarker for metabolic impairment in ischemic tissue.CONCLUSIONS: Quantitative T2* imaging might be a feasible tool to indicate change of oxygenation in acute stroke imaging, without administration of contrast agent.",
author = "Gersing, {Alexandra S} and Faymonville, {Andrea M} and Schwaiger, {Benedikt J} and Frank Leypoldt and Susanne Siemonsen and Claus Zimmer and Tim Magnus and Jens Fiehler",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2016",
month = feb,
day = "1",
doi = "10.1016/j.jneumeth.2015.11.018",
language = "English",
volume = "259",
pages = "83--89",
journal = "J NEUROSCI METH",
issn = "0165-0270",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Quantitative T2* mapping reveals early temporo-spatial dynamics in an ischemic stroke model

AU - Gersing, Alexandra S

AU - Faymonville, Andrea M

AU - Schwaiger, Benedikt J

AU - Leypoldt, Frank

AU - Siemonsen, Susanne

AU - Zimmer, Claus

AU - Magnus, Tim

AU - Fiehler, Jens

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - BACKGROUND: Oxyhemoglobin-sensitive sequences, namely T2*, can indirectly depict changes in oxygen extraction. Purpose of this study was to investigate the dynamics of T2* changes in ischemic tissue.NEW METHOD: We investigated earliest temporo-spatial dynamics within ischemic tissue, measured with quantitative T2* imaging in the histologically defined infarct core and surrounding surviving tissue. Middle cerebral artery occlusion (MCAO) was induced by a filament model in mice. Serial multiple gradient-echo T2* sequences and diffusion-weighted images were acquired for 60min after MCAO and repeated for 60min after recanalization. T2* maps were co-registered with histology and T2* changes were compared to the contralateral hemisphere.RESULTS: Within the histologically defined infarct core, relative T2* values decreased significantly by -10.8±2.8% (P=0.003) compared to the contralateral hemisphere within 3.5±0.7min after MCAO. Relative T2* values in volume exceeding the histologically determined infarct core were significantly less decreased (-6.7±2.1%; P=0.02) and increased after recanalization (+3.9±1.9%; P=0.045). Volume with T2* decrease showed continuous growth over 60min after MCAO (P=0.002) and decreased during 60min after recanalization (P=0.026), showing most significant correlations between infarct core volume and T2* abnormality volume (r=0.66; P=0.037) of the last image acquired after recanalization.COMPARISON WITH EXISTING METHOD(S): To our best knowledge, this is the first application of non-invasive quantitative T2* measurements to assess changes in levels of deoxyhemoglobin as an indirect biomarker for metabolic impairment in ischemic tissue.CONCLUSIONS: Quantitative T2* imaging might be a feasible tool to indicate change of oxygenation in acute stroke imaging, without administration of contrast agent.

AB - BACKGROUND: Oxyhemoglobin-sensitive sequences, namely T2*, can indirectly depict changes in oxygen extraction. Purpose of this study was to investigate the dynamics of T2* changes in ischemic tissue.NEW METHOD: We investigated earliest temporo-spatial dynamics within ischemic tissue, measured with quantitative T2* imaging in the histologically defined infarct core and surrounding surviving tissue. Middle cerebral artery occlusion (MCAO) was induced by a filament model in mice. Serial multiple gradient-echo T2* sequences and diffusion-weighted images were acquired for 60min after MCAO and repeated for 60min after recanalization. T2* maps were co-registered with histology and T2* changes were compared to the contralateral hemisphere.RESULTS: Within the histologically defined infarct core, relative T2* values decreased significantly by -10.8±2.8% (P=0.003) compared to the contralateral hemisphere within 3.5±0.7min after MCAO. Relative T2* values in volume exceeding the histologically determined infarct core were significantly less decreased (-6.7±2.1%; P=0.02) and increased after recanalization (+3.9±1.9%; P=0.045). Volume with T2* decrease showed continuous growth over 60min after MCAO (P=0.002) and decreased during 60min after recanalization (P=0.026), showing most significant correlations between infarct core volume and T2* abnormality volume (r=0.66; P=0.037) of the last image acquired after recanalization.COMPARISON WITH EXISTING METHOD(S): To our best knowledge, this is the first application of non-invasive quantitative T2* measurements to assess changes in levels of deoxyhemoglobin as an indirect biomarker for metabolic impairment in ischemic tissue.CONCLUSIONS: Quantitative T2* imaging might be a feasible tool to indicate change of oxygenation in acute stroke imaging, without administration of contrast agent.

U2 - 10.1016/j.jneumeth.2015.11.018

DO - 10.1016/j.jneumeth.2015.11.018

M3 - SCORING: Journal article

C2 - 26645798

VL - 259

SP - 83

EP - 89

JO - J NEUROSCI METH

JF - J NEUROSCI METH

SN - 0165-0270

ER -