Pyridine Nucleosides Neopetrosides A and B from a Marine Neopetrosia sp. Sponge. Synthesis of Neopetroside A and Its β-Riboside Analogue
Abstract
Neopetrosides A (1) and B (2), new naturally occurring ribosides of nicotinic acid with extremely rare α-N-glycoside linkages and residues of p-hydroxybenzoic and pyrrole-2-carboxylic acids attached to C-5', were isolated from a marine Neopetrosia sp. sponge. Structures 1 and 2 were determined by NMR and MS methods and confirmed by the synthesis of 1 and its β-riboside analogue (3). Neopetroside A (1) upregulates mitochondrial functions in cardiomyocytes.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 0163-3864 |
DOIs | |
Status | Veröffentlicht - 26.06.2015 |
Extern publiziert | Ja |
PubMed | 26035733 |
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