Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope
Standard
Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope. / Pecha, Simon; Hakmi, Samer; Wilke, Iris; Yildirim, Yalin; Hoffmann, Boris; Reichenspurner, Hermann; Willems, Stephan; von Kodolitsch, Yskert; Aydin, Ali.
in: HEART VESSELS, Jahrgang 31, Nr. 1, 01.2016, S. 74-79.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Pulse wave analysis of the aortic pressure waveform in patients with vasovagal syncope
AU - Pecha, Simon
AU - Hakmi, Samer
AU - Wilke, Iris
AU - Yildirim, Yalin
AU - Hoffmann, Boris
AU - Reichenspurner, Hermann
AU - Willems, Stephan
AU - von Kodolitsch, Yskert
AU - Aydin, Ali
PY - 2016/1
Y1 - 2016/1
N2 - Vascular reflex mechanisms contribute to vasovagal syncope. However, the alterations in central haemodynamics in patients with vasovagal syncope are unknown. 30 consecutive patients (36.5 ± 15 years, 14 females) with recurrent vasovagal syncope (VVS) and a positive tilt table test were compared to 39 age- and sex-matched controls (36.9 ± 16 years, 15 females) with a negative tilt table result and no history of syncope. Central aortic pressure parameters including augmentation index and central pulse pressure as markers of aortic stiffness were generated non-invasively by applanation tonometry of the radial artery and use of a validated mathematical transfer function. No difference in aortic augmentation index was observed between groups. (VVS 9 ± 2.6 vs. Control 11 ± 2.4, p = 0.8). However, in patients with vasovagal syncope the aortic pressure waveform significantly differed from healthy controls. A prolonged time to the peak of aortic pressure wave (aortic T2) was observed in patients with vasovagal syncope (226 ± 24 vs. 208 ± 21 ms, p = 0.001). Furthermore time to the first shoulder of the aortic pressure wave (aortic T1) was slightly shorter compared to healthy controls, but did not reach statistical significance (106 ± 22 vs. 110 ± 12 ms, p = 0.33). Patients with vasovagal syncope have an altered aortic pressure waveform at rest, but no signs of elevated aortic stiffness. The underlying mechanisms for these findings may potentially result from a complex imbalance of the autonomic nervous system with a continuous deregulation of the sympathetic and parasympathetic reflex arcs.
AB - Vascular reflex mechanisms contribute to vasovagal syncope. However, the alterations in central haemodynamics in patients with vasovagal syncope are unknown. 30 consecutive patients (36.5 ± 15 years, 14 females) with recurrent vasovagal syncope (VVS) and a positive tilt table test were compared to 39 age- and sex-matched controls (36.9 ± 16 years, 15 females) with a negative tilt table result and no history of syncope. Central aortic pressure parameters including augmentation index and central pulse pressure as markers of aortic stiffness were generated non-invasively by applanation tonometry of the radial artery and use of a validated mathematical transfer function. No difference in aortic augmentation index was observed between groups. (VVS 9 ± 2.6 vs. Control 11 ± 2.4, p = 0.8). However, in patients with vasovagal syncope the aortic pressure waveform significantly differed from healthy controls. A prolonged time to the peak of aortic pressure wave (aortic T2) was observed in patients with vasovagal syncope (226 ± 24 vs. 208 ± 21 ms, p = 0.001). Furthermore time to the first shoulder of the aortic pressure wave (aortic T1) was slightly shorter compared to healthy controls, but did not reach statistical significance (106 ± 22 vs. 110 ± 12 ms, p = 0.33). Patients with vasovagal syncope have an altered aortic pressure waveform at rest, but no signs of elevated aortic stiffness. The underlying mechanisms for these findings may potentially result from a complex imbalance of the autonomic nervous system with a continuous deregulation of the sympathetic and parasympathetic reflex arcs.
KW - Adult
KW - Arterial Pressure
KW - Autonomic Nervous System/physiopathology
KW - Blood Pressure
KW - Case-Control Studies
KW - Electrocardiography
KW - Female
KW - Germany
KW - Heart Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Pulse Wave Analysis
KW - Syncope, Vasovagal/physiopathology
KW - Tilt-Table Test
KW - Young Adult
U2 - 10.1007/s00380-014-0576-6
DO - 10.1007/s00380-014-0576-6
M3 - SCORING: Journal article
C2 - 25164239
VL - 31
SP - 74
EP - 79
JO - HEART VESSELS
JF - HEART VESSELS
SN - 0910-8327
IS - 1
ER -