Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids

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Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids. / Alhadad, Alaa; Acosta, Stefan; Sarabi, Latif; Kölbel, Tilo.

in: CLIN APPL THROMB-HEM, Jahrgang 16, Nr. 2, 04.2010, S. 228-231.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{f6cf4415bfe54c9496b9aef99999c9ca,
title = "Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids",
abstract = "We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.",
keywords = "Anticoagulants/therapeutic use, Blood Coagulation Factors/therapeutic use, Dalteparin/therapeutic use, Doping in Sports, Enoxaparin/therapeutic use, Hematoma, Subdural/etiology, Humans, Male, Methandrostenolone/adverse effects, Pleural Effusion/etiology, Protein C Deficiency/complications, Pulmonary Embolism/etiology, Substance-Related Disorders, Thrombophilia/chemically induced, Thrombophlebitis/drug therapy, Vena Cava Filters, Vitamin K/therapeutic use, Young Adult",
author = "Alaa Alhadad and Stefan Acosta and Latif Sarabi and Tilo K{\"o}lbel",
year = "2010",
month = apr,
doi = "10.1177/1076029608324930",
language = "English",
volume = "16",
pages = "228--231",
journal = "CLIN APPL THROMB-HEM",
issn = "1076-0296",
publisher = "SAGE Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids

AU - Alhadad, Alaa

AU - Acosta, Stefan

AU - Sarabi, Latif

AU - Kölbel, Tilo

PY - 2010/4

Y1 - 2010/4

N2 - We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.

AB - We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.

KW - Anticoagulants/therapeutic use

KW - Blood Coagulation Factors/therapeutic use

KW - Dalteparin/therapeutic use

KW - Doping in Sports

KW - Enoxaparin/therapeutic use

KW - Hematoma, Subdural/etiology

KW - Humans

KW - Male

KW - Methandrostenolone/adverse effects

KW - Pleural Effusion/etiology

KW - Protein C Deficiency/complications

KW - Pulmonary Embolism/etiology

KW - Substance-Related Disorders

KW - Thrombophilia/chemically induced

KW - Thrombophlebitis/drug therapy

KW - Vena Cava Filters

KW - Vitamin K/therapeutic use

KW - Young Adult

U2 - 10.1177/1076029608324930

DO - 10.1177/1076029608324930

M3 - SCORING: Journal article

C2 - 18977778

VL - 16

SP - 228

EP - 231

JO - CLIN APPL THROMB-HEM

JF - CLIN APPL THROMB-HEM

SN - 1076-0296

IS - 2

ER -