Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids
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Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids. / Alhadad, Alaa; Acosta, Stefan; Sarabi, Latif; Kölbel, Tilo.
in: CLIN APPL THROMB-HEM, Jahrgang 16, Nr. 2, 04.2010, S. 228-231.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids
AU - Alhadad, Alaa
AU - Acosta, Stefan
AU - Sarabi, Latif
AU - Kölbel, Tilo
PY - 2010/4
Y1 - 2010/4
N2 - We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.
AB - We present the case of a 19-year-old male athlete with protein C deficiency who developed proximal deep venous thrombosis and pulmonary embolism while abusing anabolic-androgenic steroids. Anabolic-androgenic steroids have been reported to have anticoagulatory and profibrinolytic effects in patients with protein C deficiency. Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin. The net effect of anabolic-androgenic steroids on the haemostatic system may change from antithrombotic to prothrombotic in male abusers of anabolic steroids with protein C deficiency.
KW - Anticoagulants/therapeutic use
KW - Blood Coagulation Factors/therapeutic use
KW - Dalteparin/therapeutic use
KW - Doping in Sports
KW - Enoxaparin/therapeutic use
KW - Hematoma, Subdural/etiology
KW - Humans
KW - Male
KW - Methandrostenolone/adverse effects
KW - Pleural Effusion/etiology
KW - Protein C Deficiency/complications
KW - Pulmonary Embolism/etiology
KW - Substance-Related Disorders
KW - Thrombophilia/chemically induced
KW - Thrombophlebitis/drug therapy
KW - Vena Cava Filters
KW - Vitamin K/therapeutic use
KW - Young Adult
U2 - 10.1177/1076029608324930
DO - 10.1177/1076029608324930
M3 - SCORING: Journal article
C2 - 18977778
VL - 16
SP - 228
EP - 231
JO - CLIN APPL THROMB-HEM
JF - CLIN APPL THROMB-HEM
SN - 1076-0296
IS - 2
ER -