Psychosocial distress in cancer patients undergoing radiotherapy: a prospective national cohort of 1042 patients in Germany
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Psychosocial distress in cancer patients undergoing radiotherapy: a prospective national cohort of 1042 patients in Germany. / Fabian, Alexander; Rühle, Alexander; Domschikowski, Justus; Trommer, Maike; Wegen, Simone; Becker, Jan-Niklas; Wurschi, Georg; Boeke, Simon; Sonnhoff, Mathias; Fink, Christoph A; Käsmann, Lukas; Schneider, Melanie; Bockelmann, Elodie; Treppner, Martin; Mehnert-Theuerkauf, Anja; Krug, David; Nicolay, Nils H; Young DEGRO Trial Group.
in: J CANCER RES CLIN, Jahrgang 149, Nr. 11, 09.2023, S. 9017-9024.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Psychosocial distress in cancer patients undergoing radiotherapy: a prospective national cohort of 1042 patients in Germany
AU - Fabian, Alexander
AU - Rühle, Alexander
AU - Domschikowski, Justus
AU - Trommer, Maike
AU - Wegen, Simone
AU - Becker, Jan-Niklas
AU - Wurschi, Georg
AU - Boeke, Simon
AU - Sonnhoff, Mathias
AU - Fink, Christoph A
AU - Käsmann, Lukas
AU - Schneider, Melanie
AU - Bockelmann, Elodie
AU - Treppner, Martin
AU - Mehnert-Theuerkauf, Anja
AU - Krug, David
AU - Nicolay, Nils H
AU - Young DEGRO Group
N1 - © 2023. The Author(s).
PY - 2023/9
Y1 - 2023/9
N2 - PURPOSE: Psychosocial distress is common among cancer patients in general, but those undergoing radiotherapy may face specific challenges. Therefore, we investigated the prevalence and risk factors for distress in a large national cohort.METHODS: We performed a secondary analysis of a multicenter prospective cross-sectional study which surveyed cancer patients at the end of a course of radiotherapy using a patient-reported questionnaire. Distress was measured with the distress thermometer (DT), using a cut-off of ≥ 5 points for clinically significant distress. Univariate analyses and multivariate multiple regression were used to assess associations of distress with patient characteristics. A two-sided p-value < 0.05 was considered statistically significant.RESULTS: Out of 2341 potentially eligible patients, 1075 participated in the study, of which 1042 completed the DT. The median age was 65 years and 49% (511/1042) of patients were female. The mean DT score was 5.2 (SD = 2.6). Clinically significant distress was reported by 63% (766/1042) of patients. Of the patient characteristics that were significantly associated with distress in the univariate analysis, a lower level of education, a higher degree of income loss, lower global quality of life, and a longer duration of radiotherapy in days remained significantly associated with higher distress in the multivariate analysis. Yet effect sizes of these associations were small.CONCLUSION: Nearly two in three cancer patients undergoing radiotherapy reported clinically significant distress in a large multicenter cohort. While screening and interventions to reduce distress should be maintained and promoted, the identified risk factors may help to raise awareness in clinical practice.TRIAL REGISTRY IDENTIFIER: DRKS: German Clinical Trial Registry identifier: DRKS00028784.
AB - PURPOSE: Psychosocial distress is common among cancer patients in general, but those undergoing radiotherapy may face specific challenges. Therefore, we investigated the prevalence and risk factors for distress in a large national cohort.METHODS: We performed a secondary analysis of a multicenter prospective cross-sectional study which surveyed cancer patients at the end of a course of radiotherapy using a patient-reported questionnaire. Distress was measured with the distress thermometer (DT), using a cut-off of ≥ 5 points for clinically significant distress. Univariate analyses and multivariate multiple regression were used to assess associations of distress with patient characteristics. A two-sided p-value < 0.05 was considered statistically significant.RESULTS: Out of 2341 potentially eligible patients, 1075 participated in the study, of which 1042 completed the DT. The median age was 65 years and 49% (511/1042) of patients were female. The mean DT score was 5.2 (SD = 2.6). Clinically significant distress was reported by 63% (766/1042) of patients. Of the patient characteristics that were significantly associated with distress in the univariate analysis, a lower level of education, a higher degree of income loss, lower global quality of life, and a longer duration of radiotherapy in days remained significantly associated with higher distress in the multivariate analysis. Yet effect sizes of these associations were small.CONCLUSION: Nearly two in three cancer patients undergoing radiotherapy reported clinically significant distress in a large multicenter cohort. While screening and interventions to reduce distress should be maintained and promoted, the identified risk factors may help to raise awareness in clinical practice.TRIAL REGISTRY IDENTIFIER: DRKS: German Clinical Trial Registry identifier: DRKS00028784.
KW - Humans
KW - Female
KW - Aged
KW - Male
KW - Quality of Life/psychology
KW - Cross-Sectional Studies
KW - Prospective Studies
KW - Stress, Psychological/epidemiology
KW - Neoplasms/epidemiology
KW - Surveys and Questionnaires
KW - Germany/epidemiology
U2 - 10.1007/s00432-023-04837-5
DO - 10.1007/s00432-023-04837-5
M3 - SCORING: Journal article
C2 - 37165119
VL - 149
SP - 9017
EP - 9024
JO - J CANCER RES CLIN
JF - J CANCER RES CLIN
SN - 0171-5216
IS - 11
ER -
