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Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial

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Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial. / Reimer, Jens; Schmidt, Christiane Sybille; Schulte, Bernd; Gansefort, Dirk; Gölz, Jörg; Gerken, Guido; Scherbaum, Norbert; Verthein, Uwe; Backmund, Markus.

in: CLIN INFECT DIS, Jahrgang 57 Suppl 2, 01.08.2013, S. S97-104.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Reimer, J, Schmidt, CS, Schulte, B, Gansefort, D, Gölz, J, Gerken, G, Scherbaum, N, Verthein, U & Backmund, M 2013, 'Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial', CLIN INFECT DIS, Jg. 57 Suppl 2, S. S97-104. https://doi.org/10.1093/cid/cit307

APA

Reimer, J., Schmidt, C. S., Schulte, B., Gansefort, D., Gölz, J., Gerken, G., Scherbaum, N., Verthein, U., & Backmund, M. (2013). Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial. CLIN INFECT DIS, 57 Suppl 2, S97-104. https://doi.org/10.1093/cid/cit307

Vancouver

Reimer J, Schmidt CS, Schulte B, Gansefort D, Gölz J, Gerken G et al. Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial. CLIN INFECT DIS. 2013 Aug 1;57 Suppl 2:S97-104. https://doi.org/10.1093/cid/cit307

Bibtex

@article{6f6d5b7693ae41f994d48a0a1dbd8e8f,
title = "Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial",
abstract = "BACKGROUND: People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV) infection. However, PWID are considered {"}difficult to treat,{"} requiring a specifically adapted treatment setting, including psychosocial support.METHODS: In this prospective, German trial, the impact of psychoeducation (PE) on retention and sustained virologic response (SVR) during HCV therapy among PWID was evaluated. We included 198 patients in opiate substitution therapy, who fulfilled indications for antiviral treatment. All patients received pegylated interferon alfa-2a and ribavirin therapy. Patients in the intervention group (n = 82) received manualized PE sessions.RESULTS: In patients with HCV genotype 1 or 4 (GT 1/4), PE was associated with increased treatment completion (76% vs 55%, P = .038), whereas PE had no such effect among GT 2/3 patients, who showed fewer dropouts and higher SVR rates. Among GT 1/4 patients, a minimum of 5 PE sessions was associated with increased SVR (71% vs 48%, P = .037). Multivariate regression analyses confirmed the impact of PE in GT 1/4 and revealed further predictors for retention and SVR, such as preexisting mental distress and adverse events.CONCLUSIONS: In patients with a higher risk of dropout due to GT 1/4 or mental distress, PE was shown to improve retention and SVR. PE is an effective supportive intervention for HCV therapy among PWID.",
keywords = "Adolescent, Adult, Aged, Antiviral Agents, Behavior Therapy, Female, Germany, Hepatitis C, Humans, Interferon-alpha, Male, Medication Adherence, Middle Aged, Opiate Substitution Treatment, Polyethylene Glycols, Prospective Studies, Recombinant Proteins, Ribavirin, Substance Abuse, Intravenous, Treatment Outcome, Viral Load, Young Adult",
author = "Jens Reimer and Schmidt, {Christiane Sybille} and Bernd Schulte and Dirk Gansefort and J{\"o}rg G{\"o}lz and Guido Gerken and Norbert Scherbaum and Uwe Verthein and Markus Backmund",
year = "2013",
month = aug,
day = "1",
doi = "10.1093/cid/cit307",
language = "English",
volume = "57 Suppl 2",
pages = "S97--104",
journal = "CLIN INFECT DIS",
issn = "1058-4838",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - Psychoeducation improves hepatitis C virus treatment during opioid substitution therapy: a controlled, prospective multicenter trial

AU - Reimer, Jens

AU - Schmidt, Christiane Sybille

AU - Schulte, Bernd

AU - Gansefort, Dirk

AU - Gölz, Jörg

AU - Gerken, Guido

AU - Scherbaum, Norbert

AU - Verthein, Uwe

AU - Backmund, Markus

PY - 2013/8/1

Y1 - 2013/8/1

N2 - BACKGROUND: People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV) infection. However, PWID are considered "difficult to treat," requiring a specifically adapted treatment setting, including psychosocial support.METHODS: In this prospective, German trial, the impact of psychoeducation (PE) on retention and sustained virologic response (SVR) during HCV therapy among PWID was evaluated. We included 198 patients in opiate substitution therapy, who fulfilled indications for antiviral treatment. All patients received pegylated interferon alfa-2a and ribavirin therapy. Patients in the intervention group (n = 82) received manualized PE sessions.RESULTS: In patients with HCV genotype 1 or 4 (GT 1/4), PE was associated with increased treatment completion (76% vs 55%, P = .038), whereas PE had no such effect among GT 2/3 patients, who showed fewer dropouts and higher SVR rates. Among GT 1/4 patients, a minimum of 5 PE sessions was associated with increased SVR (71% vs 48%, P = .037). Multivariate regression analyses confirmed the impact of PE in GT 1/4 and revealed further predictors for retention and SVR, such as preexisting mental distress and adverse events.CONCLUSIONS: In patients with a higher risk of dropout due to GT 1/4 or mental distress, PE was shown to improve retention and SVR. PE is an effective supportive intervention for HCV therapy among PWID.

AB - BACKGROUND: People who inject drugs (PWID) have a high prevalence of hepatitis C virus (HCV) infection. However, PWID are considered "difficult to treat," requiring a specifically adapted treatment setting, including psychosocial support.METHODS: In this prospective, German trial, the impact of psychoeducation (PE) on retention and sustained virologic response (SVR) during HCV therapy among PWID was evaluated. We included 198 patients in opiate substitution therapy, who fulfilled indications for antiviral treatment. All patients received pegylated interferon alfa-2a and ribavirin therapy. Patients in the intervention group (n = 82) received manualized PE sessions.RESULTS: In patients with HCV genotype 1 or 4 (GT 1/4), PE was associated with increased treatment completion (76% vs 55%, P = .038), whereas PE had no such effect among GT 2/3 patients, who showed fewer dropouts and higher SVR rates. Among GT 1/4 patients, a minimum of 5 PE sessions was associated with increased SVR (71% vs 48%, P = .037). Multivariate regression analyses confirmed the impact of PE in GT 1/4 and revealed further predictors for retention and SVR, such as preexisting mental distress and adverse events.CONCLUSIONS: In patients with a higher risk of dropout due to GT 1/4 or mental distress, PE was shown to improve retention and SVR. PE is an effective supportive intervention for HCV therapy among PWID.

KW - Adolescent

KW - Adult

KW - Aged

KW - Antiviral Agents

KW - Behavior Therapy

KW - Female

KW - Germany

KW - Hepatitis C

KW - Humans

KW - Interferon-alpha

KW - Male

KW - Medication Adherence

KW - Middle Aged

KW - Opiate Substitution Treatment

KW - Polyethylene Glycols

KW - Prospective Studies

KW - Recombinant Proteins

KW - Ribavirin

KW - Substance Abuse, Intravenous

KW - Treatment Outcome

KW - Viral Load

KW - Young Adult

U2 - 10.1093/cid/cit307

DO - 10.1093/cid/cit307

M3 - SCORING: Journal article

C2 - 23884073

VL - 57 Suppl 2

SP - S97-104

JO - CLIN INFECT DIS

JF - CLIN INFECT DIS

SN - 1058-4838

ER -