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Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw

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Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw. / Zustin, Josef; Reske, Dennis; Zrnc, Tomislav A; Heiland, Max; Scheuer, Hanna A; Assaf, Alexandre T; Friedrich, Reinhard E.

in: IN VIVO, Jahrgang 28, Nr. 1, 2014, S. 125-31.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zustin, J, Reske, D, Zrnc, TA, Heiland, M, Scheuer, HA, Assaf, AT & Friedrich, RE 2014, 'Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw', IN VIVO, Jg. 28, Nr. 1, S. 125-31.

APA

Zustin, J., Reske, D., Zrnc, T. A., Heiland, M., Scheuer, H. A., Assaf, A. T., & Friedrich, R. E. (2014). Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw. IN VIVO, 28(1), 125-31.

Vancouver

Zustin J, Reske D, Zrnc TA, Heiland M, Scheuer HA, Assaf AT et al. Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw. IN VIVO. 2014;28(1):125-31.

Bibtex

@article{e6632d32b19b46b3a59546f9c047c97f,
title = "Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw",
abstract = "Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-characterized oral complication of systemic therapy with bisphosphonates. Pseudoepitheliomatous hyperplasia was observed in some of the lesions. Because podoplanin expression has been linked to malignant lesions of the oral mucosa, we aimed to investigate podoplanin expression in the pseudoepitheliomatous hyperplasia. We analyzed archival paraffin- and plastic-embedded specimens from BRONJ using both conventional and immunohistochemical (AE1/AE3, D2-40) staining methods. Eleven out of seventeen BRONJ cases showed pseudoepitheliomatous hyperplasia. All these cases were positive for AE1/AE3 and pseudoepitheliomatous hyperplasia displayed a strong basal and parabasal reaction against podoplanin. The podoplanin expression in pseudoepitheliomatous hyperplasia in BRONJ specimens should not be considered a sign of malignancy. We discuss the current and possible future roles of surgical pathologists in diagnosing morphological changes associated with the development and therapy of BRONJ lesions.",
author = "Josef Zustin and Dennis Reske and Zrnc, {Tomislav A} and Max Heiland and Scheuer, {Hanna A} and Assaf, {Alexandre T} and Friedrich, {Reinhard E}",
year = "2014",
language = "English",
volume = "28",
pages = "125--31",
journal = "IN VIVO",
issn = "0258-851X",
publisher = "International Institute of Anticancer Research",
number = "1",

}

RIS

TY - JOUR

T1 - Pseudoepitheliomatous hyperplasia associated with bisphosphonate-related osteonecrosis of the jaw

AU - Zustin, Josef

AU - Reske, Dennis

AU - Zrnc, Tomislav A

AU - Heiland, Max

AU - Scheuer, Hanna A

AU - Assaf, Alexandre T

AU - Friedrich, Reinhard E

PY - 2014

Y1 - 2014

N2 - Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-characterized oral complication of systemic therapy with bisphosphonates. Pseudoepitheliomatous hyperplasia was observed in some of the lesions. Because podoplanin expression has been linked to malignant lesions of the oral mucosa, we aimed to investigate podoplanin expression in the pseudoepitheliomatous hyperplasia. We analyzed archival paraffin- and plastic-embedded specimens from BRONJ using both conventional and immunohistochemical (AE1/AE3, D2-40) staining methods. Eleven out of seventeen BRONJ cases showed pseudoepitheliomatous hyperplasia. All these cases were positive for AE1/AE3 and pseudoepitheliomatous hyperplasia displayed a strong basal and parabasal reaction against podoplanin. The podoplanin expression in pseudoepitheliomatous hyperplasia in BRONJ specimens should not be considered a sign of malignancy. We discuss the current and possible future roles of surgical pathologists in diagnosing morphological changes associated with the development and therapy of BRONJ lesions.

AB - Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a well-characterized oral complication of systemic therapy with bisphosphonates. Pseudoepitheliomatous hyperplasia was observed in some of the lesions. Because podoplanin expression has been linked to malignant lesions of the oral mucosa, we aimed to investigate podoplanin expression in the pseudoepitheliomatous hyperplasia. We analyzed archival paraffin- and plastic-embedded specimens from BRONJ using both conventional and immunohistochemical (AE1/AE3, D2-40) staining methods. Eleven out of seventeen BRONJ cases showed pseudoepitheliomatous hyperplasia. All these cases were positive for AE1/AE3 and pseudoepitheliomatous hyperplasia displayed a strong basal and parabasal reaction against podoplanin. The podoplanin expression in pseudoepitheliomatous hyperplasia in BRONJ specimens should not be considered a sign of malignancy. We discuss the current and possible future roles of surgical pathologists in diagnosing morphological changes associated with the development and therapy of BRONJ lesions.

M3 - SCORING: Journal article

C2 - 24425847

VL - 28

SP - 125

EP - 131

JO - IN VIVO

JF - IN VIVO

SN - 0258-851X

IS - 1

ER -