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Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease

Standard

Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. / Warth Perez Arias, Carmina C; Silbern, Ivan; Caldi Gomes, Lucas; Wartmann, Hannes; Dambeck, Vivian; Fanz, Jonas; Neuenroth, Lisa; Bähr, Mathias; Outeiro, Tiago F; Bonn, Stefan; Stadelmann-Nessler, Christine; Rizzoli, Silvio O; Lenz, Christof; Urlaub, Henning; Lingor, Paul.

in: J NEUROCHEM, Jahrgang 166, Nr. 5, 09.2023, S. 862-874.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Warth Perez Arias, CC, Silbern, I, Caldi Gomes, L, Wartmann, H, Dambeck, V, Fanz, J, Neuenroth, L, Bähr, M, Outeiro, TF, Bonn, S, Stadelmann-Nessler, C, Rizzoli, SO, Lenz, C, Urlaub, H & Lingor, P 2023, 'Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease', J NEUROCHEM, Jg. 166, Nr. 5, S. 862-874. https://doi.org/10.1111/jnc.15924

APA

Warth Perez Arias, C. C., Silbern, I., Caldi Gomes, L., Wartmann, H., Dambeck, V., Fanz, J., Neuenroth, L., Bähr, M., Outeiro, T. F., Bonn, S., Stadelmann-Nessler, C., Rizzoli, S. O., Lenz, C., Urlaub, H., & Lingor, P. (2023). Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. J NEUROCHEM, 166(5), 862-874. https://doi.org/10.1111/jnc.15924

Vancouver

Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J et al. Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease. J NEUROCHEM. 2023 Sep;166(5):862-874. https://doi.org/10.1111/jnc.15924

Bibtex

@article{d64ca12ae1e143a5a3912c69e8fb4796,
title = "Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease",
abstract = "Parkinson's disease (PD) affects a significant proportion of the population over the age of 60 years, and its prevalence is increasing. While symptomatic treatment is available for motor symptoms of PD, non-motor complications such as dementia result in diminished life quality for patients and are far more difficult to treat. In this study, we analyzed PD-associated alterations in the hippocampus of PD patients, since this brain region is strongly affected by PD dementia. We focused on synapses, analyzing the proteome of post-mortal hippocampal tissue from 16 PD cases and 14 control subjects by mass spectrometry. Whole tissue lysates and synaptosomal fractions were analyzed in parallel. Differential analysis combined with bioinformatic network analyses identified neuronal pentraxin 1 (NPTX1) to be significantly dysregulated in PD and interacting with proteins of the synaptic compartment. Modulation of NPTX1 protein levels in primary hippocampal neuron cultures validated its role in synapse morphology. Our analysis suggests that NPTX1 contributes to synaptic pathology in late-stage PD and represents a putative target for novel therapeutic strategies.",
keywords = "Humans, Middle Aged, Parkinson Disease/metabolism, Proteomics/methods, Hippocampus/metabolism, Alzheimer Disease/pathology",
author = "{Warth Perez Arias}, {Carmina C} and Ivan Silbern and {Caldi Gomes}, Lucas and Hannes Wartmann and Vivian Dambeck and Jonas Fanz and Lisa Neuenroth and Mathias B{\"a}hr and Outeiro, {Tiago F} and Stefan Bonn and Christine Stadelmann-Nessler and Rizzoli, {Silvio O} and Christof Lenz and Henning Urlaub and Paul Lingor",
note = "{\textcopyright} 2023 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.",
year = "2023",
month = sep,
doi = "10.1111/jnc.15924",
language = "English",
volume = "166",
pages = "862--874",
journal = "J NEUROCHEM",
issn = "0022-3042",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease

AU - Warth Perez Arias, Carmina C

AU - Silbern, Ivan

AU - Caldi Gomes, Lucas

AU - Wartmann, Hannes

AU - Dambeck, Vivian

AU - Fanz, Jonas

AU - Neuenroth, Lisa

AU - Bähr, Mathias

AU - Outeiro, Tiago F

AU - Bonn, Stefan

AU - Stadelmann-Nessler, Christine

AU - Rizzoli, Silvio O

AU - Lenz, Christof

AU - Urlaub, Henning

AU - Lingor, Paul

N1 - © 2023 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry.

PY - 2023/9

Y1 - 2023/9

N2 - Parkinson's disease (PD) affects a significant proportion of the population over the age of 60 years, and its prevalence is increasing. While symptomatic treatment is available for motor symptoms of PD, non-motor complications such as dementia result in diminished life quality for patients and are far more difficult to treat. In this study, we analyzed PD-associated alterations in the hippocampus of PD patients, since this brain region is strongly affected by PD dementia. We focused on synapses, analyzing the proteome of post-mortal hippocampal tissue from 16 PD cases and 14 control subjects by mass spectrometry. Whole tissue lysates and synaptosomal fractions were analyzed in parallel. Differential analysis combined with bioinformatic network analyses identified neuronal pentraxin 1 (NPTX1) to be significantly dysregulated in PD and interacting with proteins of the synaptic compartment. Modulation of NPTX1 protein levels in primary hippocampal neuron cultures validated its role in synapse morphology. Our analysis suggests that NPTX1 contributes to synaptic pathology in late-stage PD and represents a putative target for novel therapeutic strategies.

AB - Parkinson's disease (PD) affects a significant proportion of the population over the age of 60 years, and its prevalence is increasing. While symptomatic treatment is available for motor symptoms of PD, non-motor complications such as dementia result in diminished life quality for patients and are far more difficult to treat. In this study, we analyzed PD-associated alterations in the hippocampus of PD patients, since this brain region is strongly affected by PD dementia. We focused on synapses, analyzing the proteome of post-mortal hippocampal tissue from 16 PD cases and 14 control subjects by mass spectrometry. Whole tissue lysates and synaptosomal fractions were analyzed in parallel. Differential analysis combined with bioinformatic network analyses identified neuronal pentraxin 1 (NPTX1) to be significantly dysregulated in PD and interacting with proteins of the synaptic compartment. Modulation of NPTX1 protein levels in primary hippocampal neuron cultures validated its role in synapse morphology. Our analysis suggests that NPTX1 contributes to synaptic pathology in late-stage PD and represents a putative target for novel therapeutic strategies.

KW - Humans

KW - Middle Aged

KW - Parkinson Disease/metabolism

KW - Proteomics/methods

KW - Hippocampus/metabolism

KW - Alzheimer Disease/pathology

U2 - 10.1111/jnc.15924

DO - 10.1111/jnc.15924

M3 - SCORING: Journal article

C2 - 37515330

VL - 166

SP - 862

EP - 874

JO - J NEUROCHEM

JF - J NEUROCHEM

SN - 0022-3042

IS - 5

ER -