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Proteolysis and inflammation of the kidney glomerulus

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Proteolysis and inflammation of the kidney glomerulus. / Demir, Fatih; Troldborg, Anne; Thiel, Steffen; Lassé, Moritz; Huesgen, Pitter F; Tomas, Nicola M; Wiech, Thorsten; Rinschen, Markus M.

in: CELL TISSUE RES, Jahrgang 385, Nr. 2, 08.2021, S. 489-500.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Demir, F, Troldborg, A, Thiel, S, Lassé, M, Huesgen, PF, Tomas, NM, Wiech, T & Rinschen, MM 2021, 'Proteolysis and inflammation of the kidney glomerulus', CELL TISSUE RES, Jg. 385, Nr. 2, S. 489-500. https://doi.org/10.1007/s00441-021-03433-8

APA

Demir, F., Troldborg, A., Thiel, S., Lassé, M., Huesgen, P. F., Tomas, N. M., Wiech, T., & Rinschen, M. M. (2021). Proteolysis and inflammation of the kidney glomerulus. CELL TISSUE RES, 385(2), 489-500. https://doi.org/10.1007/s00441-021-03433-8

Vancouver

Demir F, Troldborg A, Thiel S, Lassé M, Huesgen PF, Tomas NM et al. Proteolysis and inflammation of the kidney glomerulus. CELL TISSUE RES. 2021 Aug;385(2):489-500. https://doi.org/10.1007/s00441-021-03433-8

Bibtex

@article{5a8f44fbf75a47e981546207bd692be7,
title = "Proteolysis and inflammation of the kidney glomerulus",
abstract = "Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases, lupus nephritis, and membranous nephropathy, we portrait two proteolytic pathomechanisms and the role of the complement system. We discuss how profiling proteolytic activity in patient samples could be used to stratify patients for more targeted interventions in inflammatory kidney diseases. We also describe novel comprehensive, quantitative tools to investigate the entirety of proteolytic processes in a tissue sample. Emphasis is placed on mass spectrometric approaches that enable the comprehensive analysis of the complement system, as well as protease activities and regulation in general.",
author = "Fatih Demir and Anne Troldborg and Steffen Thiel and Moritz Lass{\'e} and Huesgen, {Pitter F} and Tomas, {Nicola M} and Thorsten Wiech and Rinschen, {Markus M}",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = aug,
doi = "10.1007/s00441-021-03433-8",
language = "English",
volume = "385",
pages = "489--500",
journal = "CELL TISSUE RES",
issn = "0302-766X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Proteolysis and inflammation of the kidney glomerulus

AU - Demir, Fatih

AU - Troldborg, Anne

AU - Thiel, Steffen

AU - Lassé, Moritz

AU - Huesgen, Pitter F

AU - Tomas, Nicola M

AU - Wiech, Thorsten

AU - Rinschen, Markus M

N1 - © 2021. The Author(s).

PY - 2021/8

Y1 - 2021/8

N2 - Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases, lupus nephritis, and membranous nephropathy, we portrait two proteolytic pathomechanisms and the role of the complement system. We discuss how profiling proteolytic activity in patient samples could be used to stratify patients for more targeted interventions in inflammatory kidney diseases. We also describe novel comprehensive, quantitative tools to investigate the entirety of proteolytic processes in a tissue sample. Emphasis is placed on mass spectrometric approaches that enable the comprehensive analysis of the complement system, as well as protease activities and regulation in general.

AB - Proteases play a central role in regulating renal pathophysiology and are increasingly evaluated as actionable drug targets. Here, we review the role of proteolytic systems in inflammatory kidney disease. Inflammatory kidney diseases are associated with broad dysregulations of extracellular and intracellular proteolysis. As an example of a proteolytic system, the complement system plays a significant role in glomerular inflammatory kidney disease and is currently under clinical investigation. Based on two glomerular kidney diseases, lupus nephritis, and membranous nephropathy, we portrait two proteolytic pathomechanisms and the role of the complement system. We discuss how profiling proteolytic activity in patient samples could be used to stratify patients for more targeted interventions in inflammatory kidney diseases. We also describe novel comprehensive, quantitative tools to investigate the entirety of proteolytic processes in a tissue sample. Emphasis is placed on mass spectrometric approaches that enable the comprehensive analysis of the complement system, as well as protease activities and regulation in general.

U2 - 10.1007/s00441-021-03433-8

DO - 10.1007/s00441-021-03433-8

M3 - SCORING: Review article

C2 - 33864499

VL - 385

SP - 489

EP - 500

JO - CELL TISSUE RES

JF - CELL TISSUE RES

SN - 0302-766X

IS - 2

ER -