PortalPublikationenProtein expression of close homologue of L1 (CHL1) is a mark...

Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC)

Standard

Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC). / Hötzel, Jenny; Melling, Nathaniel; Müller, Julia; Polonski, Adam; Wolters-Eisfeld, Gerrit; Izbicki, Jakob R; Karstens, Karl-F; Tachezy, Michael.

in: J CANCER RES CLIN, Jahrgang 145, Nr. 9, 09.2019, S. 2285-2292.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hötzel, J, Melling, N, Müller, J, Polonski, A, Wolters-Eisfeld, G, Izbicki, JR, Karstens, K-F & Tachezy, M 2019, 'Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC)', J CANCER RES CLIN, Jg. 145, Nr. 9, S. 2285-2292. https://doi.org/10.1007/s00432-019-02989-x

APA

Hötzel, J., Melling, N., Müller, J., Polonski, A., Wolters-Eisfeld, G., Izbicki, J. R., Karstens, K-F., & Tachezy, M. (2019). Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC). J CANCER RES CLIN, 145(9), 2285-2292. https://doi.org/10.1007/s00432-019-02989-x

Vancouver

Hötzel J, Melling N, Müller J, Polonski A, Wolters-Eisfeld G, Izbicki JR et al. Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC). J CANCER RES CLIN. 2019 Sep;145(9):2285-2292. https://doi.org/10.1007/s00432-019-02989-x

Bibtex

@article{64f5a4312bb74c90b7437a3334345dd0,
title = "Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC)",
abstract = "BACKGROUND: The cell adhesion molecule close homologue of L1 (CHL1) is a potential tumour suppressor and was recently detected in non-small cell lung cancer (NSCLC) specimens. The expression pattern, prognostic, and functional role of CHL1 in NSCLCs is unknown.METHODS: We evaluated the protein expression of CHL1 by immunohistochemistry in 2161 NSCLC patients based on a tissue microarray. The results were correlated with clinical, histopathological, and patient survival data (Chi square test, t test, and log-rank test, respectively). A multivariate analysis (Cox regression) was performed to validate its impact on patients' survival.RESULTS: CHL1 was expressed in NSCLC patients and was significantly overexpressed in lung adenocarcinomas and squamous cell carcinomas compared to neuroendocrine and large cell carcinomas of the lung (p < 0.001). CHL1 expression was associated with the T stage in adenocarcinomas (p = 0.011) and with metastatic lymph node status and UICC stage in squamous cell carcinomas (p = 0.034 and p = 0.035, respectively). Increased CHL1 expression was associated with improved survival in univariate (p = 0.031) and multivariate analyses (odds ratio 0.797, 95% confidence interval 0.677-0.939, p = 0.007).CONCLUSION: The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.",
keywords = "Adenocarcinoma/diagnosis, Aged, Biomarkers, Tumor/metabolism, Carcinoma, Non-Small-Cell Lung/diagnosis, Carcinoma, Squamous Cell/diagnosis, Cell Adhesion Molecules/metabolism, Female, Follow-Up Studies, Humans, Immunohistochemistry, Lung Neoplasms/diagnosis, Male, Middle Aged, Neoplasm Staging, Prognosis, Survival Analysis, Tissue Array Analysis",
author = "Jenny H{\"o}tzel and Nathaniel Melling and Julia M{\"u}ller and Adam Polonski and Gerrit Wolters-Eisfeld and Izbicki, {Jakob R} and Karl-F Karstens and Michael Tachezy",
year = "2019",
month = sep,
doi = "10.1007/s00432-019-02989-x",
language = "English",
volume = "145",
pages = "2285--2292",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Protein expression of close homologue of L1 (CHL1) is a marker for overall survival in non-small cell lung cancer (NSCLC)

AU - Hötzel, Jenny

AU - Melling, Nathaniel

AU - Müller, Julia

AU - Polonski, Adam

AU - Wolters-Eisfeld, Gerrit

AU - Izbicki, Jakob R

AU - Karstens, Karl-F

AU - Tachezy, Michael

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND: The cell adhesion molecule close homologue of L1 (CHL1) is a potential tumour suppressor and was recently detected in non-small cell lung cancer (NSCLC) specimens. The expression pattern, prognostic, and functional role of CHL1 in NSCLCs is unknown.METHODS: We evaluated the protein expression of CHL1 by immunohistochemistry in 2161 NSCLC patients based on a tissue microarray. The results were correlated with clinical, histopathological, and patient survival data (Chi square test, t test, and log-rank test, respectively). A multivariate analysis (Cox regression) was performed to validate its impact on patients' survival.RESULTS: CHL1 was expressed in NSCLC patients and was significantly overexpressed in lung adenocarcinomas and squamous cell carcinomas compared to neuroendocrine and large cell carcinomas of the lung (p < 0.001). CHL1 expression was associated with the T stage in adenocarcinomas (p = 0.011) and with metastatic lymph node status and UICC stage in squamous cell carcinomas (p = 0.034 and p = 0.035, respectively). Increased CHL1 expression was associated with improved survival in univariate (p = 0.031) and multivariate analyses (odds ratio 0.797, 95% confidence interval 0.677-0.939, p = 0.007).CONCLUSION: The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.

AB - BACKGROUND: The cell adhesion molecule close homologue of L1 (CHL1) is a potential tumour suppressor and was recently detected in non-small cell lung cancer (NSCLC) specimens. The expression pattern, prognostic, and functional role of CHL1 in NSCLCs is unknown.METHODS: We evaluated the protein expression of CHL1 by immunohistochemistry in 2161 NSCLC patients based on a tissue microarray. The results were correlated with clinical, histopathological, and patient survival data (Chi square test, t test, and log-rank test, respectively). A multivariate analysis (Cox regression) was performed to validate its impact on patients' survival.RESULTS: CHL1 was expressed in NSCLC patients and was significantly overexpressed in lung adenocarcinomas and squamous cell carcinomas compared to neuroendocrine and large cell carcinomas of the lung (p < 0.001). CHL1 expression was associated with the T stage in adenocarcinomas (p = 0.011) and with metastatic lymph node status and UICC stage in squamous cell carcinomas (p = 0.034 and p = 0.035, respectively). Increased CHL1 expression was associated with improved survival in univariate (p = 0.031) and multivariate analyses (odds ratio 0.797, 95% confidence interval 0.677-0.939, p = 0.007).CONCLUSION: The prognostic significance of CHL1 makes it a potential prognostic and therapeutic target and underlines its role as a tumour suppressor. Further validation studies and functional analyses are needed to investigate its potential role in tumourigenesis and dissemination.

KW - Adenocarcinoma/diagnosis

KW - Aged

KW - Biomarkers, Tumor/metabolism

KW - Carcinoma, Non-Small-Cell Lung/diagnosis

KW - Carcinoma, Squamous Cell/diagnosis

KW - Cell Adhesion Molecules/metabolism

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Immunohistochemistry

KW - Lung Neoplasms/diagnosis

KW - Male

KW - Middle Aged

KW - Neoplasm Staging

KW - Prognosis

KW - Survival Analysis

KW - Tissue Array Analysis

U2 - 10.1007/s00432-019-02989-x

DO - 10.1007/s00432-019-02989-x

M3 - SCORING: Journal article

C2 - 31372722

VL - 145

SP - 2285

EP - 2292

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 9

ER -