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Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin

Standard

Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin. / Henningsen, Maike; Kilic, Ergin; Koehler, Nadine; Löning, Thomas; Witzel, Isabell; Hagel, Christian; Höller, Sylvia; Kersten, Jan Felix; Müller, Volkmar; Jänicke, Fritz; Milde-Langosch, Karin.

in: J CLIN PATHOL, Jahrgang 64, Nr. 2, 2, 2011, S. 146-152.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Henningsen, M, Kilic, E, Koehler, N, Löning, T, Witzel, I, Hagel, C, Höller, S, Kersten, JF, Müller, V, Jänicke, F & Milde-Langosch, K 2011, 'Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin', J CLIN PATHOL, Jg. 64, Nr. 2, 2, S. 146-152. https://doi.org/10.1136/jcp.2010.082602

APA

Henningsen, M., Kilic, E., Koehler, N., Löning, T., Witzel, I., Hagel, C., Höller, S., Kersten, J. F., Müller, V., Jänicke, F., & Milde-Langosch, K. (2011). Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin. J CLIN PATHOL, 64(2), 146-152. [2]. https://doi.org/10.1136/jcp.2010.082602

Vancouver

Henningsen M, Kilic E, Koehler N, Löning T, Witzel I, Hagel C et al. Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin. J CLIN PATHOL. 2011;64(2):146-152. 2. https://doi.org/10.1136/jcp.2010.082602

Bibtex

@article{63f38d68635849bca7219420e8b916ac,
title = "Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin",
abstract = "For prediction and understanding of underlying mechanisms of organ-specific metastases, various gene and protein expression signatures have been identified in primary breast carcinomas. These expression signatures often include several genes coding for adhesion molecules, such as activated leucocyte cell adhesion molecule (ALCAM/CD166) and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), both of which may play an important role in the development of distant metastases because of their adherent properties. Owing to their predominantly membranous localisation, they are also considered to have certain therapeutic potential. Apart from expression data obtained in the primary tumour, data for gene and protein expression patterns in distant breast cancer metastases are rare. Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites.",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Antigens, CD/*metabolism, Cell Adhesion Molecules, Neuronal/*metabolism, Fetal Proteins/*metabolism, Liver Neoplasms/metabolism/secondary, Bone Neoplasms/metabolism/secondary, Brain Neoplasms/metabolism/secondary, Breast Neoplasms/*metabolism, Cell Adhesion Molecules/*metabolism, GPI-Linked Proteins/metabolism, Lung Neoplasms/metabolism/secondary, Neoplasm Proteins/*metabolism, Skin Neoplasms/metabolism/*secondary, Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Antigens, CD/*metabolism, Cell Adhesion Molecules, Neuronal/*metabolism, Fetal Proteins/*metabolism, Liver Neoplasms/metabolism/secondary, Bone Neoplasms/metabolism/secondary, Brain Neoplasms/metabolism/secondary, Breast Neoplasms/*metabolism, Cell Adhesion Molecules/*metabolism, GPI-Linked Proteins/metabolism, Lung Neoplasms/metabolism/secondary, Neoplasm Proteins/*metabolism, Skin Neoplasms/metabolism/*secondary",
author = "Maike Henningsen and Ergin Kilic and Nadine Koehler and Thomas L{\"o}ning and Isabell Witzel and Christian Hagel and Sylvia H{\"o}ller and Kersten, {Jan Felix} and Volkmar M{\"u}ller and Fritz J{\"a}nicke and Karin Milde-Langosch",
year = "2011",
doi = "10.1136/jcp.2010.082602",
language = "English",
volume = "64",
pages = "146--152",
journal = "J CLIN PATHOL",
issn = "0021-9746",
publisher = "BMJ PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - Protein expression analysis of ALCAM and CEACAM6 in breast cancer metastases reveals significantly increased ALCAM expression in metastases of the skin

AU - Henningsen, Maike

AU - Kilic, Ergin

AU - Koehler, Nadine

AU - Löning, Thomas

AU - Witzel, Isabell

AU - Hagel, Christian

AU - Höller, Sylvia

AU - Kersten, Jan Felix

AU - Müller, Volkmar

AU - Jänicke, Fritz

AU - Milde-Langosch, Karin

PY - 2011

Y1 - 2011

N2 - For prediction and understanding of underlying mechanisms of organ-specific metastases, various gene and protein expression signatures have been identified in primary breast carcinomas. These expression signatures often include several genes coding for adhesion molecules, such as activated leucocyte cell adhesion molecule (ALCAM/CD166) and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), both of which may play an important role in the development of distant metastases because of their adherent properties. Owing to their predominantly membranous localisation, they are also considered to have certain therapeutic potential. Apart from expression data obtained in the primary tumour, data for gene and protein expression patterns in distant breast cancer metastases are rare. Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites.

AB - For prediction and understanding of underlying mechanisms of organ-specific metastases, various gene and protein expression signatures have been identified in primary breast carcinomas. These expression signatures often include several genes coding for adhesion molecules, such as activated leucocyte cell adhesion molecule (ALCAM/CD166) and carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), both of which may play an important role in the development of distant metastases because of their adherent properties. Owing to their predominantly membranous localisation, they are also considered to have certain therapeutic potential. Apart from expression data obtained in the primary tumour, data for gene and protein expression patterns in distant breast cancer metastases are rare. Therefore this study focuses on analysing the distribution of ALCAM and CEACAM6 protein expression in breast cancer metastases from different sites.

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Antigens, CD/metabolism

KW - Cell Adhesion Molecules, Neuronal/metabolism

KW - Fetal Proteins/metabolism

KW - Liver Neoplasms/metabolism/secondary

KW - Bone Neoplasms/metabolism/secondary

KW - Brain Neoplasms/metabolism/secondary

KW - Breast Neoplasms/metabolism

KW - Cell Adhesion Molecules/metabolism

KW - GPI-Linked Proteins/metabolism

KW - Lung Neoplasms/metabolism/secondary

KW - Neoplasm Proteins/metabolism

KW - Skin Neoplasms/metabolism/secondary

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Antigens, CD/metabolism

KW - Cell Adhesion Molecules, Neuronal/metabolism

KW - Fetal Proteins/metabolism

KW - Liver Neoplasms/metabolism/secondary

KW - Bone Neoplasms/metabolism/secondary

KW - Brain Neoplasms/metabolism/secondary

KW - Breast Neoplasms/metabolism

KW - Cell Adhesion Molecules/metabolism

KW - GPI-Linked Proteins/metabolism

KW - Lung Neoplasms/metabolism/secondary

KW - Neoplasm Proteins/metabolism

KW - Skin Neoplasms/metabolism/secondary

U2 - 10.1136/jcp.2010.082602

DO - 10.1136/jcp.2010.082602

M3 - SCORING: Journal article

VL - 64

SP - 146

EP - 152

JO - J CLIN PATHOL

JF - J CLIN PATHOL

SN - 0021-9746

IS - 2

M1 - 2

ER -