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Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants

Standard

Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants. / Härtel, Christoph; Pagel, Julia; Rupp, Jan; Bendiks, Meike; Guthmann, Florian; Rieger-Fackeldey, Esther; Heckmann, Matthias; Franz, Axel; Schiffmann, Jan-Holger; Zimmermann, Beate; Hepping, Nico; von der Wense, Axel; Wieg, Christian; Herting, Egbert; Göpel, Wolfgang; German Neonatal Network (GNN).

in: J PEDIATR-US, Jahrgang 165, Nr. 2, 08.2014, S. 285-289.e1.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Härtel, C, Pagel, J, Rupp, J, Bendiks, M, Guthmann, F, Rieger-Fackeldey, E, Heckmann, M, Franz, A, Schiffmann, J-H, Zimmermann, B, Hepping, N, von der Wense, A, Wieg, C, Herting, E, Göpel, W & German Neonatal Network (GNN) 2014, 'Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants', J PEDIATR-US, Jg. 165, Nr. 2, S. 285-289.e1. https://doi.org/10.1016/j.jpeds.2014.04.029

APA

Härtel, C., Pagel, J., Rupp, J., Bendiks, M., Guthmann, F., Rieger-Fackeldey, E., Heckmann, M., Franz, A., Schiffmann, J-H., Zimmermann, B., Hepping, N., von der Wense, A., Wieg, C., Herting, E., Göpel, W., & German Neonatal Network (GNN) (2014). Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants. J PEDIATR-US, 165(2), 285-289.e1. https://doi.org/10.1016/j.jpeds.2014.04.029

Vancouver

Härtel C, Pagel J, Rupp J, Bendiks M, Guthmann F, Rieger-Fackeldey E et al. Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants. J PEDIATR-US. 2014 Aug;165(2):285-289.e1. https://doi.org/10.1016/j.jpeds.2014.04.029

Bibtex

@article{b097d67aff154488aab5ad83260e07ea,
title = "Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants",
abstract = "OBJECTIVE: To evaluate outcome data in an observational cohort of very low birth weight infants of the German Neonatal Network stratified to prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics.STUDY DESIGN: Within the observational period (September 1, 2010, until December 31, 2012, n=5351 infants) study centers were categorized into 3 groups based on their choice of Lactobacillus acidophilus/Bifidobacterium infantis use: (1) no prophylactic use (12 centers); (2 a/b) change of strategy nonuser to user during observational period (13 centers); and (3) use before start of observation (21 centers). Primary outcome data of all eligible infants were determined according to center-specific strategy.RESULTS: The use of probiotics was associated with a reduced risk for necrotizing enterocolitis surgery (group 1 vs group 3: 4.2 vs 2.6%, P=.028; change of strategy: 6.2 vs 4.0%, P<.001), any abdominal surgery, and hospital mortality. Infants treated with probiotics had improved weight gain/day, and probiotics had no effect on the risk of blood-culture confirmed sepsis. In a multivariable logistic regression analysis, probiotics were protective for necrotizing enterocolitis surgery (OR 0.58, 95% CI 0.37-0.91; P=.017), any abdominal surgery (OR 0.7, 95% CI 0.51-0.95; P=.02), and the combined outcome abdominal surgery and/or death (OR 0.43; 95% CI 0.33-0.56; P<.001).CONCLUSIONS: Our observational data support the use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics to reduce the risk for gastrointestinal morbidity but not sepsis in very low birth weight infants.",
keywords = "Bifidobacterium, Cohort Studies, Enterocolitis, Necrotizing/epidemiology, Female, Germany, Hospital Mortality, Humans, Infant, Infant, Very Low Birth Weight, Lactobacillus acidophilus, Male, Probiotics/administration & dosage, Risk Factors, Treatment Outcome",
author = "Christoph H{\"a}rtel and Julia Pagel and Jan Rupp and Meike Bendiks and Florian Guthmann and Esther Rieger-Fackeldey and Matthias Heckmann and Axel Franz and Jan-Holger Schiffmann and Beate Zimmermann and Nico Hepping and {von der Wense}, Axel and Christian Wieg and Egbert Herting and Wolfgang G{\"o}pel and {German Neonatal Network (GNN)}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2014",
month = aug,
doi = "10.1016/j.jpeds.2014.04.029",
language = "English",
volume = "165",
pages = "285--289.e1",
journal = "J PEDIATR-US",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics and outcome in very low birth weight infants

AU - Härtel, Christoph

AU - Pagel, Julia

AU - Rupp, Jan

AU - Bendiks, Meike

AU - Guthmann, Florian

AU - Rieger-Fackeldey, Esther

AU - Heckmann, Matthias

AU - Franz, Axel

AU - Schiffmann, Jan-Holger

AU - Zimmermann, Beate

AU - Hepping, Nico

AU - von der Wense, Axel

AU - Wieg, Christian

AU - Herting, Egbert

AU - Göpel, Wolfgang

AU - German Neonatal Network (GNN)

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2014/8

Y1 - 2014/8

N2 - OBJECTIVE: To evaluate outcome data in an observational cohort of very low birth weight infants of the German Neonatal Network stratified to prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics.STUDY DESIGN: Within the observational period (September 1, 2010, until December 31, 2012, n=5351 infants) study centers were categorized into 3 groups based on their choice of Lactobacillus acidophilus/Bifidobacterium infantis use: (1) no prophylactic use (12 centers); (2 a/b) change of strategy nonuser to user during observational period (13 centers); and (3) use before start of observation (21 centers). Primary outcome data of all eligible infants were determined according to center-specific strategy.RESULTS: The use of probiotics was associated with a reduced risk for necrotizing enterocolitis surgery (group 1 vs group 3: 4.2 vs 2.6%, P=.028; change of strategy: 6.2 vs 4.0%, P<.001), any abdominal surgery, and hospital mortality. Infants treated with probiotics had improved weight gain/day, and probiotics had no effect on the risk of blood-culture confirmed sepsis. In a multivariable logistic regression analysis, probiotics were protective for necrotizing enterocolitis surgery (OR 0.58, 95% CI 0.37-0.91; P=.017), any abdominal surgery (OR 0.7, 95% CI 0.51-0.95; P=.02), and the combined outcome abdominal surgery and/or death (OR 0.43; 95% CI 0.33-0.56; P<.001).CONCLUSIONS: Our observational data support the use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics to reduce the risk for gastrointestinal morbidity but not sepsis in very low birth weight infants.

AB - OBJECTIVE: To evaluate outcome data in an observational cohort of very low birth weight infants of the German Neonatal Network stratified to prophylactic use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics.STUDY DESIGN: Within the observational period (September 1, 2010, until December 31, 2012, n=5351 infants) study centers were categorized into 3 groups based on their choice of Lactobacillus acidophilus/Bifidobacterium infantis use: (1) no prophylactic use (12 centers); (2 a/b) change of strategy nonuser to user during observational period (13 centers); and (3) use before start of observation (21 centers). Primary outcome data of all eligible infants were determined according to center-specific strategy.RESULTS: The use of probiotics was associated with a reduced risk for necrotizing enterocolitis surgery (group 1 vs group 3: 4.2 vs 2.6%, P=.028; change of strategy: 6.2 vs 4.0%, P<.001), any abdominal surgery, and hospital mortality. Infants treated with probiotics had improved weight gain/day, and probiotics had no effect on the risk of blood-culture confirmed sepsis. In a multivariable logistic regression analysis, probiotics were protective for necrotizing enterocolitis surgery (OR 0.58, 95% CI 0.37-0.91; P=.017), any abdominal surgery (OR 0.7, 95% CI 0.51-0.95; P=.02), and the combined outcome abdominal surgery and/or death (OR 0.43; 95% CI 0.33-0.56; P<.001).CONCLUSIONS: Our observational data support the use of Lactobacillus acidophilus/Bifidobacterium infantis probiotics to reduce the risk for gastrointestinal morbidity but not sepsis in very low birth weight infants.

KW - Bifidobacterium

KW - Cohort Studies

KW - Enterocolitis, Necrotizing/epidemiology

KW - Female

KW - Germany

KW - Hospital Mortality

KW - Humans

KW - Infant

KW - Infant, Very Low Birth Weight

KW - Lactobacillus acidophilus

KW - Male

KW - Probiotics/administration & dosage

KW - Risk Factors

KW - Treatment Outcome

U2 - 10.1016/j.jpeds.2014.04.029

DO - 10.1016/j.jpeds.2014.04.029

M3 - SCORING: Journal article

C2 - 24880888

VL - 165

SP - 285-289.e1

JO - J PEDIATR-US

JF - J PEDIATR-US

SN - 0022-3476

IS - 2

ER -