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Properties of voltage-gated chloride channels of the ClC gene family

Standard

Properties of voltage-gated chloride channels of the ClC gene family. / Jentsch, T J; Günther, W; Pusch, M; Schwappach, B.

in: J PHYSIOL-LONDON, Jahrgang 482, 01.1995, S. 19S-25S.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Jentsch, TJ, Günther, W, Pusch, M & Schwappach, B 1995, 'Properties of voltage-gated chloride channels of the ClC gene family', J PHYSIOL-LONDON, Jg. 482, S. 19S-25S. https://doi.org/10.1113/jphysiol.1995.sp020560

APA

Jentsch, T. J., Günther, W., Pusch, M., & Schwappach, B. (1995). Properties of voltage-gated chloride channels of the ClC gene family. J PHYSIOL-LONDON, 482, 19S-25S. https://doi.org/10.1113/jphysiol.1995.sp020560

Vancouver

Jentsch TJ, Günther W, Pusch M, Schwappach B. Properties of voltage-gated chloride channels of the ClC gene family. J PHYSIOL-LONDON. 1995 Jan;482:19S-25S. https://doi.org/10.1113/jphysiol.1995.sp020560

Bibtex

@article{bbca123a7d694c1994858cad68f47ab5,
title = "Properties of voltage-gated chloride channels of the ClC gene family",
abstract = "We review the properties of ClC chloride channels, members of an expanding gene family originally discovered by the cloning of the ClC-0 chloride channel from Torpedo electric organ. There are at least nine different ClC genes in mammals, several of which seem to be expressed ubiquitously, while others are expressed in a highly specific manner (e.g. the muscle-specific ClC-1 channel and the kidney-specific ClC-K channels). The newly cloned rat ClC-4 is strongly expressed in liver and brain, but also in heart, muscle, kidney and spleen. ClC chloride channels are structurally unrelated to other channel proteins and have twelve putative transmembrane domains. They function as multimers with probably four subunits. Functional characterization is most advanced with ClC-0, ClC-1 (mutations which cause myotonia) and ClC-2, a swelling-activated chloride channel. Many of the new ClC family members cannot yet be expressed functionally.",
keywords = "Amino Acid Sequence, Animals, Chloride Channels/genetics, Humans, Ion Channel Gating/genetics, Molecular Sequence Data, Rats",
author = "Jentsch, {T J} and W G{\"u}nther and M Pusch and B Schwappach",
year = "1995",
month = jan,
doi = "10.1113/jphysiol.1995.sp020560",
language = "English",
volume = "482",
pages = "19S--25S",
journal = "J PHYSIOL-LONDON",
issn = "0022-3751",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Properties of voltage-gated chloride channels of the ClC gene family

AU - Jentsch, T J

AU - Günther, W

AU - Pusch, M

AU - Schwappach, B

PY - 1995/1

Y1 - 1995/1

N2 - We review the properties of ClC chloride channels, members of an expanding gene family originally discovered by the cloning of the ClC-0 chloride channel from Torpedo electric organ. There are at least nine different ClC genes in mammals, several of which seem to be expressed ubiquitously, while others are expressed in a highly specific manner (e.g. the muscle-specific ClC-1 channel and the kidney-specific ClC-K channels). The newly cloned rat ClC-4 is strongly expressed in liver and brain, but also in heart, muscle, kidney and spleen. ClC chloride channels are structurally unrelated to other channel proteins and have twelve putative transmembrane domains. They function as multimers with probably four subunits. Functional characterization is most advanced with ClC-0, ClC-1 (mutations which cause myotonia) and ClC-2, a swelling-activated chloride channel. Many of the new ClC family members cannot yet be expressed functionally.

AB - We review the properties of ClC chloride channels, members of an expanding gene family originally discovered by the cloning of the ClC-0 chloride channel from Torpedo electric organ. There are at least nine different ClC genes in mammals, several of which seem to be expressed ubiquitously, while others are expressed in a highly specific manner (e.g. the muscle-specific ClC-1 channel and the kidney-specific ClC-K channels). The newly cloned rat ClC-4 is strongly expressed in liver and brain, but also in heart, muscle, kidney and spleen. ClC chloride channels are structurally unrelated to other channel proteins and have twelve putative transmembrane domains. They function as multimers with probably four subunits. Functional characterization is most advanced with ClC-0, ClC-1 (mutations which cause myotonia) and ClC-2, a swelling-activated chloride channel. Many of the new ClC family members cannot yet be expressed functionally.

KW - Amino Acid Sequence

KW - Animals

KW - Chloride Channels/genetics

KW - Humans

KW - Ion Channel Gating/genetics

KW - Molecular Sequence Data

KW - Rats

U2 - 10.1113/jphysiol.1995.sp020560

DO - 10.1113/jphysiol.1995.sp020560

M3 - SCORING: Review article

C2 - 7730971

VL - 482

SP - 19S-25S

JO - J PHYSIOL-LONDON

JF - J PHYSIOL-LONDON

SN - 0022-3751

ER -