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Proper layering is important for precisely timed activation of hippocampal mossy cells.

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Proper layering is important for precisely timed activation of hippocampal mossy cells. / Kowalski, Janina; Geuting, Markus; Paul, Sebastian; Dieni, Sandra; Laurens, Jean; Zhao, Shanting; Drakew, Alexander; Haas, Carola A; Frotscher, Michael; Vida, Imre.

in: CEREB CORTEX, Jahrgang 20, Nr. 9, 9, 2010, S. 2043-2054.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kowalski, J, Geuting, M, Paul, S, Dieni, S, Laurens, J, Zhao, S, Drakew, A, Haas, CA, Frotscher, M & Vida, I 2010, 'Proper layering is important for precisely timed activation of hippocampal mossy cells.', CEREB CORTEX, Jg. 20, Nr. 9, 9, S. 2043-2054. <http://www.ncbi.nlm.nih.gov/pubmed/20053714?dopt=Citation>

APA

Kowalski, J., Geuting, M., Paul, S., Dieni, S., Laurens, J., Zhao, S., Drakew, A., Haas, C. A., Frotscher, M., & Vida, I. (2010). Proper layering is important for precisely timed activation of hippocampal mossy cells. CEREB CORTEX, 20(9), 2043-2054. [9]. http://www.ncbi.nlm.nih.gov/pubmed/20053714?dopt=Citation

Vancouver

Kowalski J, Geuting M, Paul S, Dieni S, Laurens J, Zhao S et al. Proper layering is important for precisely timed activation of hippocampal mossy cells. CEREB CORTEX. 2010;20(9):2043-2054. 9.

Bibtex

@article{4946246daadd45ee9ee211a35abc4393,
title = "Proper layering is important for precisely timed activation of hippocampal mossy cells.",
abstract = "The mammalian cortex exhibits a laminated structure that may underlie optimal synaptic connectivity and support temporally precise activation of neurons. In 'reeler' mice, the lack of the extracellular matrix protein Reelin leads to abnormal positioning of cortical neurons and disrupted layering. To address how these structural changes impact neuronal function, we combined electrophysiological and neuroanatomical techniques to investigate the synaptic activation of hippocampal mossy cells (MCs), the cell type that integrates the output of dentate gyrus granule cells (GCs). While somatodendritic domains of wild-type (WT) MCs were confined to the hilus, the somata and dendrites of reeler MCs were often found in the molecular layer, where the perforant path (PP) terminates. Most reeler MCs received aberrant monosynaptic excitatory input from the PP, whereas the disynaptic input to MCs via GCs was decreased and inhibition was increased. In contrast to the uniform disynaptic discharge of WT MCs, many reeler cells discharged with short, monosynaptic latencies, while others fired with long latencies over a broad temporal window in response to PP activation. Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing.",
keywords = "Animals, Mice, Cell Adhesion Molecules, Neuronal deficiency, Extracellular Matrix Proteins deficiency, Nerve Tissue Proteins deficiency, Serine Endopeptidases deficiency, Neurons cytology, Action Potentials genetics, Mice, Neurologic Mutants, Neurogenesis genetics, Body Patterning genetics, Mice, Inbred Strains, Mossy Fibers, Hippocampal abnormalities, Synaptic Transmission genetics, Animals, Mice, Cell Adhesion Molecules, Neuronal deficiency, Extracellular Matrix Proteins deficiency, Nerve Tissue Proteins deficiency, Serine Endopeptidases deficiency, Neurons cytology, Action Potentials genetics, Mice, Neurologic Mutants, Neurogenesis genetics, Body Patterning genetics, Mice, Inbred Strains, Mossy Fibers, Hippocampal abnormalities, Synaptic Transmission genetics",
author = "Janina Kowalski and Markus Geuting and Sebastian Paul and Sandra Dieni and Jean Laurens and Shanting Zhao and Alexander Drakew and Haas, {Carola A} and Michael Frotscher and Imre Vida",
year = "2010",
language = "Deutsch",
volume = "20",
pages = "2043--2054",
journal = "CEREB CORTEX",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Proper layering is important for precisely timed activation of hippocampal mossy cells.

AU - Kowalski, Janina

AU - Geuting, Markus

AU - Paul, Sebastian

AU - Dieni, Sandra

AU - Laurens, Jean

AU - Zhao, Shanting

AU - Drakew, Alexander

AU - Haas, Carola A

AU - Frotscher, Michael

AU - Vida, Imre

PY - 2010

Y1 - 2010

N2 - The mammalian cortex exhibits a laminated structure that may underlie optimal synaptic connectivity and support temporally precise activation of neurons. In 'reeler' mice, the lack of the extracellular matrix protein Reelin leads to abnormal positioning of cortical neurons and disrupted layering. To address how these structural changes impact neuronal function, we combined electrophysiological and neuroanatomical techniques to investigate the synaptic activation of hippocampal mossy cells (MCs), the cell type that integrates the output of dentate gyrus granule cells (GCs). While somatodendritic domains of wild-type (WT) MCs were confined to the hilus, the somata and dendrites of reeler MCs were often found in the molecular layer, where the perforant path (PP) terminates. Most reeler MCs received aberrant monosynaptic excitatory input from the PP, whereas the disynaptic input to MCs via GCs was decreased and inhibition was increased. In contrast to the uniform disynaptic discharge of WT MCs, many reeler cells discharged with short, monosynaptic latencies, while others fired with long latencies over a broad temporal window in response to PP activation. Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing.

AB - The mammalian cortex exhibits a laminated structure that may underlie optimal synaptic connectivity and support temporally precise activation of neurons. In 'reeler' mice, the lack of the extracellular matrix protein Reelin leads to abnormal positioning of cortical neurons and disrupted layering. To address how these structural changes impact neuronal function, we combined electrophysiological and neuroanatomical techniques to investigate the synaptic activation of hippocampal mossy cells (MCs), the cell type that integrates the output of dentate gyrus granule cells (GCs). While somatodendritic domains of wild-type (WT) MCs were confined to the hilus, the somata and dendrites of reeler MCs were often found in the molecular layer, where the perforant path (PP) terminates. Most reeler MCs received aberrant monosynaptic excitatory input from the PP, whereas the disynaptic input to MCs via GCs was decreased and inhibition was increased. In contrast to the uniform disynaptic discharge of WT MCs, many reeler cells discharged with short, monosynaptic latencies, while others fired with long latencies over a broad temporal window in response to PP activation. Thus, disturbed lamination results in aberrant synaptic connectivity and altered timing of action potential generation. These results highlight the importance of a layered cortical structure for information processing.

KW - Animals

KW - Mice

KW - Cell Adhesion Molecules, Neuronal deficiency

KW - Extracellular Matrix Proteins deficiency

KW - Nerve Tissue Proteins deficiency

KW - Serine Endopeptidases deficiency

KW - Neurons cytology

KW - Action Potentials genetics

KW - Mice, Neurologic Mutants

KW - Neurogenesis genetics

KW - Body Patterning genetics

KW - Mice, Inbred Strains

KW - Mossy Fibers, Hippocampal abnormalities

KW - Synaptic Transmission genetics

KW - Animals

KW - Mice

KW - Cell Adhesion Molecules, Neuronal deficiency

KW - Extracellular Matrix Proteins deficiency

KW - Nerve Tissue Proteins deficiency

KW - Serine Endopeptidases deficiency

KW - Neurons cytology

KW - Action Potentials genetics

KW - Mice, Neurologic Mutants

KW - Neurogenesis genetics

KW - Body Patterning genetics

KW - Mice, Inbred Strains

KW - Mossy Fibers, Hippocampal abnormalities

KW - Synaptic Transmission genetics

M3 - SCORING: Zeitschriftenaufsatz

VL - 20

SP - 2043

EP - 2054

JO - CEREB CORTEX

JF - CEREB CORTEX

SN - 1047-3211

IS - 9

M1 - 9

ER -