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Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy

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Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy. / Moschini, Marco; Soria, Francesco; Mathieu, Romain; Xylinas, Evanguelos; D'Andrea, David; Tan, Wei Shen; Kelly, John D; Simone, Giuseppe; Tuderti, Gabriele; Meraney, Anoop; Krishna, Suprita; Konety, Badrianath; Zamboni, Stefania; Baumeister, Philipp; Mattei, Agostino; Briganti, Alberto; Montorsi, Francesco; Galucci, Michele; Rink, Michael; Karakiewicz, Pierre I; Rouprêt, Morgan; Aziz, Atiqullah; Perry, Matt; Rowe, Edward; Koupparis, Anthony; Kassouf, Wassim; Scherr, Douglas S; Ploussard, Guillaume; Boorjian, Stephen A; Sooriakumaran, Prasanna; Shariat, Shahrokh F; European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group.

in: UROL ONCOL-SEMIN ORI, Jahrgang 37, Nr. 3, 03.2019, S. 179.e1-179.e7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Moschini, M, Soria, F, Mathieu, R, Xylinas, E, D'Andrea, D, Tan, WS, Kelly, JD, Simone, G, Tuderti, G, Meraney, A, Krishna, S, Konety, B, Zamboni, S, Baumeister, P, Mattei, A, Briganti, A, Montorsi, F, Galucci, M, Rink, M, Karakiewicz, PI, Rouprêt, M, Aziz, A, Perry, M, Rowe, E, Koupparis, A, Kassouf, W, Scherr, DS, Ploussard, G, Boorjian, SA, Sooriakumaran, P, Shariat, SF & European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group 2019, 'Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy', UROL ONCOL-SEMIN ORI, Jg. 37, Nr. 3, S. 179.e1-179.e7. https://doi.org/10.1016/j.urolonc.2018.10.012

APA

Moschini, M., Soria, F., Mathieu, R., Xylinas, E., D'Andrea, D., Tan, W. S., Kelly, J. D., Simone, G., Tuderti, G., Meraney, A., Krishna, S., Konety, B., Zamboni, S., Baumeister, P., Mattei, A., Briganti, A., Montorsi, F., Galucci, M., Rink, M., ... European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group (2019). Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy. UROL ONCOL-SEMIN ORI, 37(3), 179.e1-179.e7. https://doi.org/10.1016/j.urolonc.2018.10.012

Vancouver

Moschini M, Soria F, Mathieu R, Xylinas E, D'Andrea D, Tan WS et al. Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy. UROL ONCOL-SEMIN ORI. 2019 Mär;37(3):179.e1-179.e7. https://doi.org/10.1016/j.urolonc.2018.10.012

Bibtex

@article{a8ef1fc1762e46918bc555a08aa7d407,
title = "Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy",
abstract = "INTRODUCTION: The use of robotic-assisted radical cystectomy (RARC) is becoming more widespread. While its safety is accepted, its oncological efficacy as compared to the current standard, open radical cystectomy (ORC), remains debatable.MATERIALS AND METHODS: The aim of this study is to compare the rates of positive soft tissue surgical margins (STSM), between patients treated with RARC or ORC, using a large contemporaneous collaborative database. We included 2,536 patients with urothelial carcinoma of the bladder treated at 26 institutions. A propensity-score matching 1:1 was performed with 3 ORC patients matched to 1 RARC patient. The final cohort included 1,614 patients. Uni- and multivariable logistic regression analyses tested the impact of surgical technique on STSM status, before and after propensity-score matching.RESULTS: Overall, 870 (34%) patients underwent RARC and 1,666 (66%) ORC. The overall STSM rate was 11%; 10% in the ORC group and 13% in the RARC group. Within the propensity-score-matched cohort, the positive STSM rate were 14% and 13% in the ORC and RARC group, respectively (P = 0.1). In multivariable analysis, after propensity match RARC approach was not associated with the risk of a positive STSM (P = 0.1). These results were confirmed in the subgroup of patients with pathologic non-organ-confined or organ-confined diseases.CONCLUSIONS: While treatment with RARC is associated with a higher absolute rate of STSM, the difference did not remain after adjustment for the effects of other established prognostic factors. Results from ongoing trials are awaited to assess the validity of these findings.",
keywords = "Journal Article",
author = "Marco Moschini and Francesco Soria and Romain Mathieu and Evanguelos Xylinas and David D'Andrea and Tan, {Wei Shen} and Kelly, {John D} and Giuseppe Simone and Gabriele Tuderti and Anoop Meraney and Suprita Krishna and Badrianath Konety and Stefania Zamboni and Philipp Baumeister and Agostino Mattei and Alberto Briganti and Francesco Montorsi and Michele Galucci and Michael Rink and Karakiewicz, {Pierre I} and Morgan Roupr{\^e}t and Atiqullah Aziz and Matt Perry and Edward Rowe and Anthony Koupparis and Wassim Kassouf and Scherr, {Douglas S} and Guillaume Ploussard and Boorjian, {Stephen A} and Prasanna Sooriakumaran and Shariat, {Shahrokh F} and {European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group}",
note = "Copyright {\textcopyright} 2018. Published by Elsevier Inc.",
year = "2019",
month = mar,
doi = "10.1016/j.urolonc.2018.10.012",
language = "English",
volume = "37",
pages = "179.e1--179.e7",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Propensity-score-matched comparison of soft tissue surgical margins status between open and robotic-assisted radical cystectomy

AU - Moschini, Marco

AU - Soria, Francesco

AU - Mathieu, Romain

AU - Xylinas, Evanguelos

AU - D'Andrea, David

AU - Tan, Wei Shen

AU - Kelly, John D

AU - Simone, Giuseppe

AU - Tuderti, Gabriele

AU - Meraney, Anoop

AU - Krishna, Suprita

AU - Konety, Badrianath

AU - Zamboni, Stefania

AU - Baumeister, Philipp

AU - Mattei, Agostino

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Galucci, Michele

AU - Rink, Michael

AU - Karakiewicz, Pierre I

AU - Rouprêt, Morgan

AU - Aziz, Atiqullah

AU - Perry, Matt

AU - Rowe, Edward

AU - Koupparis, Anthony

AU - Kassouf, Wassim

AU - Scherr, Douglas S

AU - Ploussard, Guillaume

AU - Boorjian, Stephen A

AU - Sooriakumaran, Prasanna

AU - Shariat, Shahrokh F

AU - European Association of Urology – Young Academic Urologists (EAU-YAU), Urothelial Carcinoma Working Group

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2019/3

Y1 - 2019/3

N2 - INTRODUCTION: The use of robotic-assisted radical cystectomy (RARC) is becoming more widespread. While its safety is accepted, its oncological efficacy as compared to the current standard, open radical cystectomy (ORC), remains debatable.MATERIALS AND METHODS: The aim of this study is to compare the rates of positive soft tissue surgical margins (STSM), between patients treated with RARC or ORC, using a large contemporaneous collaborative database. We included 2,536 patients with urothelial carcinoma of the bladder treated at 26 institutions. A propensity-score matching 1:1 was performed with 3 ORC patients matched to 1 RARC patient. The final cohort included 1,614 patients. Uni- and multivariable logistic regression analyses tested the impact of surgical technique on STSM status, before and after propensity-score matching.RESULTS: Overall, 870 (34%) patients underwent RARC and 1,666 (66%) ORC. The overall STSM rate was 11%; 10% in the ORC group and 13% in the RARC group. Within the propensity-score-matched cohort, the positive STSM rate were 14% and 13% in the ORC and RARC group, respectively (P = 0.1). In multivariable analysis, after propensity match RARC approach was not associated with the risk of a positive STSM (P = 0.1). These results were confirmed in the subgroup of patients with pathologic non-organ-confined or organ-confined diseases.CONCLUSIONS: While treatment with RARC is associated with a higher absolute rate of STSM, the difference did not remain after adjustment for the effects of other established prognostic factors. Results from ongoing trials are awaited to assess the validity of these findings.

AB - INTRODUCTION: The use of robotic-assisted radical cystectomy (RARC) is becoming more widespread. While its safety is accepted, its oncological efficacy as compared to the current standard, open radical cystectomy (ORC), remains debatable.MATERIALS AND METHODS: The aim of this study is to compare the rates of positive soft tissue surgical margins (STSM), between patients treated with RARC or ORC, using a large contemporaneous collaborative database. We included 2,536 patients with urothelial carcinoma of the bladder treated at 26 institutions. A propensity-score matching 1:1 was performed with 3 ORC patients matched to 1 RARC patient. The final cohort included 1,614 patients. Uni- and multivariable logistic regression analyses tested the impact of surgical technique on STSM status, before and after propensity-score matching.RESULTS: Overall, 870 (34%) patients underwent RARC and 1,666 (66%) ORC. The overall STSM rate was 11%; 10% in the ORC group and 13% in the RARC group. Within the propensity-score-matched cohort, the positive STSM rate were 14% and 13% in the ORC and RARC group, respectively (P = 0.1). In multivariable analysis, after propensity match RARC approach was not associated with the risk of a positive STSM (P = 0.1). These results were confirmed in the subgroup of patients with pathologic non-organ-confined or organ-confined diseases.CONCLUSIONS: While treatment with RARC is associated with a higher absolute rate of STSM, the difference did not remain after adjustment for the effects of other established prognostic factors. Results from ongoing trials are awaited to assess the validity of these findings.

KW - Journal Article

U2 - 10.1016/j.urolonc.2018.10.012

DO - 10.1016/j.urolonc.2018.10.012

M3 - SCORING: Journal article

C2 - 30446442

VL - 37

SP - 179.e1-179.e7

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 3

ER -