Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer
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Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer. / zu Eulenburg, Christine; Suling, Anna ; Neuser, Petra; Reuss, Alexander; Canzler, Ulrich; Fehm, Tanja; Luyten, Alexander; Hellriegel, Martin; Woelber, Linn; Mahner, Sven.
in: PLOS ONE, Jahrgang 11, Nr. 11, 2016, S. e0165705.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Propensity Scoring after Multiple Imputation in a Retrospective Study on Adjuvant Radiation Therapy in Lymph-Node Positive Vulvar Cancer
AU - zu Eulenburg, Christine
AU - Suling, Anna
AU - Neuser, Petra
AU - Reuss, Alexander
AU - Canzler, Ulrich
AU - Fehm, Tanja
AU - Luyten, Alexander
AU - Hellriegel, Martin
AU - Woelber, Linn
AU - Mahner, Sven
PY - 2016
Y1 - 2016
N2 - Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE). Methodological issues are described in detail. Interpretation of the results and methodological limitations are discussed.
AB - Propensity scoring (PS) is an established tool to account for measured confounding in non-randomized studies. These methods are sensitive to missing values, which are a common problem in observational data. The combination of multiple imputation of missing values and different propensity scoring techniques is addressed in this work. For a sample of lymph node-positive vulvar cancer patients, we re-analyze associations between the application of radiotherapy and disease-related and non-related survival. Inverse-probability-of-treatment-weighting (IPTW) and PS stratification are applied after multiple imputation by chained equation (MICE). Methodological issues are described in detail. Interpretation of the results and methodological limitations are discussed.
U2 - 10.1371/journal.pone.0165705
DO - 10.1371/journal.pone.0165705
M3 - SCORING: Journal article
C2 - 27802342
VL - 11
SP - e0165705
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
ER -