PortalPublikationenPromyelocytic leukaemia zinc finger protein (PLZF) is a gluc...

Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells

Standard

Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells. / Fahnenstich, Jasmin; Nandy, Andreas; Milde-Langosch, Karin; Schneider-Merck, Tanja; Walther, Norbert; Gellersen, Birgit.

in: MOL HUM REPROD, Jahrgang 9, Nr. 10, 10.2003, S. 611-23.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fahnenstich, J, Nandy, A, Milde-Langosch, K, Schneider-Merck, T, Walther, N & Gellersen, B 2003, 'Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells', MOL HUM REPROD, Jg. 9, Nr. 10, S. 611-23.

APA

Fahnenstich, J., Nandy, A., Milde-Langosch, K., Schneider-Merck, T., Walther, N., & Gellersen, B. (2003). Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells. MOL HUM REPROD, 9(10), 611-23.

Vancouver

Fahnenstich J, Nandy A, Milde-Langosch K, Schneider-Merck T, Walther N, Gellersen B. Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells. MOL HUM REPROD. 2003 Okt;9(10):611-23.

Bibtex

@article{120d109cbdc0422996310328b6e29c38,
title = "Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells",
abstract = "The promyelocytic leukaemia zinc finger (PLZF) protein belongs to the family of Kr{\"u}ppel-like zinc finger proteins. It is a transcriptional repressor involved in cell cycle control and has been implicated in limb development, differentiation of myeloid cells, and spermatogenesis. Little is known about the regulation of PLZF expression. In search for mediators of progesterone signalling in the female reproductive tract, we discovered induction of PLZF mRNA in primary cultures of human endometrial stromal cells and myometrial smooth muscle cells (SMC) in response to progesterone. Surprisingly, dexamethasone was a more potent inducer of PLZF expression than progesterone and elicited a sustained up-regulation of PLZF mRNA levels within 2 h. Immunofluorescence showed localization of PLZF to the nuclei of dexamethasone-treated SMC. In uterine biopsies, nuclear staining for PLZF was found in myometrial cells and endometrial stromal cells of the secretory phase. The transcriptional start site of the PLZF gene was located to position -5801 in SMC. Transfected promoter constructs containing up to 4.1 kb of 5'-flanking DNA were not induced by activated glucocorticoid or progesterone receptor. In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression.",
keywords = "Base Sequence, Cells, Cultured, DNA-Binding Proteins, Dexamethasone, Endometrium, Female, Glucocorticoids, Humans, Kruppel-Like Transcription Factors, Molecular Sequence Data, Myocytes, Smooth Muscle, Myometrium, Progesterone, Promoter Regions, Genetic, RNA, Messenger, Receptors, Glucocorticoid, Receptors, Progesterone, Sequence Alignment, Signal Transduction, Stromal Cells, Transcription Factor AP-1, Transcription Factors, Transcription Initiation Site, Tretinoin, Up-Regulation",
author = "Jasmin Fahnenstich and Andreas Nandy and Karin Milde-Langosch and Tanja Schneider-Merck and Norbert Walther and Birgit Gellersen",
year = "2003",
month = oct,
language = "English",
volume = "9",
pages = "611--23",
journal = "MOL HUM REPROD",
issn = "1360-9947",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells

AU - Fahnenstich, Jasmin

AU - Nandy, Andreas

AU - Milde-Langosch, Karin

AU - Schneider-Merck, Tanja

AU - Walther, Norbert

AU - Gellersen, Birgit

PY - 2003/10

Y1 - 2003/10

N2 - The promyelocytic leukaemia zinc finger (PLZF) protein belongs to the family of Krüppel-like zinc finger proteins. It is a transcriptional repressor involved in cell cycle control and has been implicated in limb development, differentiation of myeloid cells, and spermatogenesis. Little is known about the regulation of PLZF expression. In search for mediators of progesterone signalling in the female reproductive tract, we discovered induction of PLZF mRNA in primary cultures of human endometrial stromal cells and myometrial smooth muscle cells (SMC) in response to progesterone. Surprisingly, dexamethasone was a more potent inducer of PLZF expression than progesterone and elicited a sustained up-regulation of PLZF mRNA levels within 2 h. Immunofluorescence showed localization of PLZF to the nuclei of dexamethasone-treated SMC. In uterine biopsies, nuclear staining for PLZF was found in myometrial cells and endometrial stromal cells of the secretory phase. The transcriptional start site of the PLZF gene was located to position -5801 in SMC. Transfected promoter constructs containing up to 4.1 kb of 5'-flanking DNA were not induced by activated glucocorticoid or progesterone receptor. In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression.

AB - The promyelocytic leukaemia zinc finger (PLZF) protein belongs to the family of Krüppel-like zinc finger proteins. It is a transcriptional repressor involved in cell cycle control and has been implicated in limb development, differentiation of myeloid cells, and spermatogenesis. Little is known about the regulation of PLZF expression. In search for mediators of progesterone signalling in the female reproductive tract, we discovered induction of PLZF mRNA in primary cultures of human endometrial stromal cells and myometrial smooth muscle cells (SMC) in response to progesterone. Surprisingly, dexamethasone was a more potent inducer of PLZF expression than progesterone and elicited a sustained up-regulation of PLZF mRNA levels within 2 h. Immunofluorescence showed localization of PLZF to the nuclei of dexamethasone-treated SMC. In uterine biopsies, nuclear staining for PLZF was found in myometrial cells and endometrial stromal cells of the secretory phase. The transcriptional start site of the PLZF gene was located to position -5801 in SMC. Transfected promoter constructs containing up to 4.1 kb of 5'-flanking DNA were not induced by activated glucocorticoid or progesterone receptor. In contrast, co-transfection of c-jun and c-fos expression vectors resulted in stimulation of reporter gene activity, indicating an involvement of AP-1 transcription factors in PLZF expression.

KW - Base Sequence

KW - Cells, Cultured

KW - DNA-Binding Proteins

KW - Dexamethasone

KW - Endometrium

KW - Female

KW - Glucocorticoids

KW - Humans

KW - Kruppel-Like Transcription Factors

KW - Molecular Sequence Data

KW - Myocytes, Smooth Muscle

KW - Myometrium

KW - Progesterone

KW - Promoter Regions, Genetic

KW - RNA, Messenger

KW - Receptors, Glucocorticoid

KW - Receptors, Progesterone

KW - Sequence Alignment

KW - Signal Transduction

KW - Stromal Cells

KW - Transcription Factor AP-1

KW - Transcription Factors

KW - Transcription Initiation Site

KW - Tretinoin

KW - Up-Regulation

M3 - SCORING: Journal article

C2 - 12970399

VL - 9

SP - 611

EP - 623

JO - MOL HUM REPROD

JF - MOL HUM REPROD

SN - 1360-9947

IS - 10

ER -