Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications.

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Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications. / Müller, Imke; Wischnewski, Frank; Pantel, Klaus; Schwarzenbach, Heidi.

in: BMC CANCER, Jahrgang 10, 2010, S. 297.

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@article{6e516192afc04be4a074ea5d9cfdd190,
title = "Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications.",
abstract = "The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts such as the prostate cancer cells DU145 and LNCaP, and the breast cancer cells MCF-7. Since global chromatin changes have been shown to occur in tumours and regions of tumour-associated genes are affected by epigenetic modifications, these may constitute important regulatory mechanisms for the pathogenesis of malignant transformation.",
author = "Imke M{\"u}ller and Frank Wischnewski and Klaus Pantel and Heidi Schwarzenbach",
year = "2010",
doi = "10.1186/1471-2407-10-297",
language = "Deutsch",
volume = "10",
pages = "297",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Promoter- and cell-specific epigenetic regulation of CD44, Cyclin D2, GLIPR1 and PTEN by methyl-CpG binding proteins and histone modifications.

AU - Müller, Imke

AU - Wischnewski, Frank

AU - Pantel, Klaus

AU - Schwarzenbach, Heidi

PY - 2010

Y1 - 2010

N2 - The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts such as the prostate cancer cells DU145 and LNCaP, and the breast cancer cells MCF-7. Since global chromatin changes have been shown to occur in tumours and regions of tumour-associated genes are affected by epigenetic modifications, these may constitute important regulatory mechanisms for the pathogenesis of malignant transformation.

AB - The aim of the current study was to analyze the involvement of methyl-CpG binding proteins (MBDs) and histone modifications on the regulation of CD44, Cyclin D2, GLIPR1 and PTEN in different cellular contexts such as the prostate cancer cells DU145 and LNCaP, and the breast cancer cells MCF-7. Since global chromatin changes have been shown to occur in tumours and regions of tumour-associated genes are affected by epigenetic modifications, these may constitute important regulatory mechanisms for the pathogenesis of malignant transformation.

U2 - 10.1186/1471-2407-10-297

DO - 10.1186/1471-2407-10-297

M3 - SCORING: Zeitschriftenaufsatz

VL - 10

SP - 297

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -