Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia.
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Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia. / Hoser, Melanie; Baader, Stephan L; Bösl, Maria; Ihmer, Alice; Wegner, Michael; Sock, Elisabeth.
in: J NEUROSCI, Jahrgang 27, Nr. 20, 20, 2007, S. 5495-5505.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Prolonged glial expression of Sox4 in the CNS leads to architectural cerebellar defects and ataxia.
AU - Hoser, Melanie
AU - Baader, Stephan L
AU - Bösl, Maria
AU - Ihmer, Alice
AU - Wegner, Michael
AU - Sock, Elisabeth
PY - 2007
Y1 - 2007
N2 - Sox proteins of group C are strongly expressed in the developing nervous system and have been associated with maturation of neurons and glia. Here, we overexpressed the group C protein Sox4 in transgenic mice under the control of the human GFAP promoter. Transgene expression was detected in radial glia and astrocytes throughout the CNS. The transgenic mice were ataxic and exhibited hydrocephaly as well as cerebellar malformations. In the cerebellum, fissures were not formed and neuronal layering was dramatically disturbed. Nevertheless, all neuronal cell types of the cerebellum were present as well as cells with characteristics of early radial glia, astrocytes, and oligodendrocytes. However, radial glia failed to migrate into the position normally taken by Bergmann glia and did not extend radial fibers toward the pial surface. The cerebellar malformations can therefore be explained by the absence of functional Bergmann glia. We conclude that Sox4 expression counteracts differentiation of radial glia and has to be downregulated before full maturation can occur.
AB - Sox proteins of group C are strongly expressed in the developing nervous system and have been associated with maturation of neurons and glia. Here, we overexpressed the group C protein Sox4 in transgenic mice under the control of the human GFAP promoter. Transgene expression was detected in radial glia and astrocytes throughout the CNS. The transgenic mice were ataxic and exhibited hydrocephaly as well as cerebellar malformations. In the cerebellum, fissures were not formed and neuronal layering was dramatically disturbed. Nevertheless, all neuronal cell types of the cerebellum were present as well as cells with characteristics of early radial glia, astrocytes, and oligodendrocytes. However, radial glia failed to migrate into the position normally taken by Bergmann glia and did not extend radial fibers toward the pial surface. The cerebellar malformations can therefore be explained by the absence of functional Bergmann glia. We conclude that Sox4 expression counteracts differentiation of radial glia and has to be downregulated before full maturation can occur.
M3 - SCORING: Zeitschriftenaufsatz
VL - 27
SP - 5495
EP - 5505
JO - J NEUROSCI
JF - J NEUROSCI
SN - 0270-6474
IS - 20
M1 - 20
ER -
