Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma
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Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma. / Hartmann, Jörg T; Meisinger, Ines; Kröber, Stefan M; Weisel, Katja; Klingel, Karin; Kanz, Lothar.
in: HAEMATOLOGICA, Jahrgang 91, Nr. 12 Suppl, 12.2006, S. ECR49.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma
AU - Hartmann, Jörg T
AU - Meisinger, Ines
AU - Kröber, Stefan M
AU - Weisel, Katja
AU - Klingel, Karin
AU - Kanz, Lothar
PY - 2006/12
Y1 - 2006/12
N2 - Human parvovirus B 19 is known as a virus causing erythema infectiosum, arthropathy, transient aplastic crisis and intrauterine fetal death. Healthy hosts are able to clear the virus within weeks after infection. There are a few reports available in the literature regarding immunocompromised renal transplant recipients with persistent infection without seroconversion. Herein, we describe a 56-year old woman with a relapse of grade II follicular lymphoma who received a combined immunochemotherapy of rituximab, fludarabine and cyclophosphamide and subsequently developed a persistent parvovirus B19 infection. In the absence of serum immunoglobulin antibodies, PCR analysis of peripheral blood and bone marrow aspirate were positive for parvovirus B19. Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks.
AB - Human parvovirus B 19 is known as a virus causing erythema infectiosum, arthropathy, transient aplastic crisis and intrauterine fetal death. Healthy hosts are able to clear the virus within weeks after infection. There are a few reports available in the literature regarding immunocompromised renal transplant recipients with persistent infection without seroconversion. Herein, we describe a 56-year old woman with a relapse of grade II follicular lymphoma who received a combined immunochemotherapy of rituximab, fludarabine and cyclophosphamide and subsequently developed a persistent parvovirus B19 infection. In the absence of serum immunoglobulin antibodies, PCR analysis of peripheral blood and bone marrow aspirate were positive for parvovirus B19. Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks.
KW - Anemia
KW - Antibodies, Monoclonal
KW - Antibodies, Monoclonal, Murine-Derived
KW - Antineoplastic Combined Chemotherapy Protocols
KW - Bone Marrow
KW - Combined Modality Therapy
KW - Cyclophosphamide
KW - Doxorubicin
KW - Female
KW - Humans
KW - Immunocompromised Host
KW - Immunoglobulins, Intravenous
KW - Immunotherapy
KW - Leukopenia
KW - Lymphoma, Follicular
KW - Middle Aged
KW - Parvoviridae Infections
KW - Parvovirus B19, Human
KW - Prednisolone
KW - Recurrence
KW - Rituximab
KW - Vidarabine
KW - Vincristine
KW - Viremia
KW - Case Reports
KW - Journal Article
M3 - SCORING: Journal article
C2 - 17194655
VL - 91
SP - ECR49
JO - HAEMATOLOGICA
JF - HAEMATOLOGICA
SN - 0390-6078
IS - 12 Suppl
ER -