Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma

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Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma. / Hartmann, Jörg T; Meisinger, Ines; Kröber, Stefan M; Weisel, Katja; Klingel, Karin; Kanz, Lothar.

in: HAEMATOLOGICA, Jahrgang 91, Nr. 12 Suppl, 12.2006, S. ECR49.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{1acc09021b60421893d291762f5ca803,
title = "Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma",
abstract = "Human parvovirus B 19 is known as a virus causing erythema infectiosum, arthropathy, transient aplastic crisis and intrauterine fetal death. Healthy hosts are able to clear the virus within weeks after infection. There are a few reports available in the literature regarding immunocompromised renal transplant recipients with persistent infection without seroconversion. Herein, we describe a 56-year old woman with a relapse of grade II follicular lymphoma who received a combined immunochemotherapy of rituximab, fludarabine and cyclophosphamide and subsequently developed a persistent parvovirus B19 infection. In the absence of serum immunoglobulin antibodies, PCR analysis of peripheral blood and bone marrow aspirate were positive for parvovirus B19. Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks.",
keywords = "Anemia, Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow, Combined Modality Therapy, Cyclophosphamide, Doxorubicin, Female, Humans, Immunocompromised Host, Immunoglobulins, Intravenous, Immunotherapy, Leukopenia, Lymphoma, Follicular, Middle Aged, Parvoviridae Infections, Parvovirus B19, Human, Prednisolone, Recurrence, Rituximab, Vidarabine, Vincristine, Viremia, Case Reports, Journal Article",
author = "Hartmann, {J{\"o}rg T} and Ines Meisinger and Kr{\"o}ber, {Stefan M} and Katja Weisel and Karin Klingel and Lothar Kanz",
year = "2006",
month = dec,
language = "English",
volume = "91",
pages = "ECR49",
journal = "HAEMATOLOGICA",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "12 Suppl",

}

RIS

TY - JOUR

T1 - Progressive bicytopenia due to persistent parvovirus B19 infection after immunochemotherapy with fludarabine/cyclophosphamide and rituximab for relapsed B cell lymphoma

AU - Hartmann, Jörg T

AU - Meisinger, Ines

AU - Kröber, Stefan M

AU - Weisel, Katja

AU - Klingel, Karin

AU - Kanz, Lothar

PY - 2006/12

Y1 - 2006/12

N2 - Human parvovirus B 19 is known as a virus causing erythema infectiosum, arthropathy, transient aplastic crisis and intrauterine fetal death. Healthy hosts are able to clear the virus within weeks after infection. There are a few reports available in the literature regarding immunocompromised renal transplant recipients with persistent infection without seroconversion. Herein, we describe a 56-year old woman with a relapse of grade II follicular lymphoma who received a combined immunochemotherapy of rituximab, fludarabine and cyclophosphamide and subsequently developed a persistent parvovirus B19 infection. In the absence of serum immunoglobulin antibodies, PCR analysis of peripheral blood and bone marrow aspirate were positive for parvovirus B19. Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks.

AB - Human parvovirus B 19 is known as a virus causing erythema infectiosum, arthropathy, transient aplastic crisis and intrauterine fetal death. Healthy hosts are able to clear the virus within weeks after infection. There are a few reports available in the literature regarding immunocompromised renal transplant recipients with persistent infection without seroconversion. Herein, we describe a 56-year old woman with a relapse of grade II follicular lymphoma who received a combined immunochemotherapy of rituximab, fludarabine and cyclophosphamide and subsequently developed a persistent parvovirus B19 infection. In the absence of serum immunoglobulin antibodies, PCR analysis of peripheral blood and bone marrow aspirate were positive for parvovirus B19. Treatment with IVIG treatment resulted in normalization of peripheral blood counts within 7 weeks.

KW - Anemia

KW - Antibodies, Monoclonal

KW - Antibodies, Monoclonal, Murine-Derived

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Bone Marrow

KW - Combined Modality Therapy

KW - Cyclophosphamide

KW - Doxorubicin

KW - Female

KW - Humans

KW - Immunocompromised Host

KW - Immunoglobulins, Intravenous

KW - Immunotherapy

KW - Leukopenia

KW - Lymphoma, Follicular

KW - Middle Aged

KW - Parvoviridae Infections

KW - Parvovirus B19, Human

KW - Prednisolone

KW - Recurrence

KW - Rituximab

KW - Vidarabine

KW - Vincristine

KW - Viremia

KW - Case Reports

KW - Journal Article

M3 - SCORING: Journal article

C2 - 17194655

VL - 91

SP - ECR49

JO - HAEMATOLOGICA

JF - HAEMATOLOGICA

SN - 0390-6078

IS - 12 Suppl

ER -