PortalPublikationenPrognostic Value of Undetectable hs Troponin T in Suspected ...

Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome

Standard

Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome. / Vafaie, Mehrshad; Slagman, Anna; Möckel, Martin; Hamm, Christian; Huber, Kurt; Müller, Christian; Vollert, Jörn O; Blankenberg, Stefan; Katus, Hugo A; Liebetrau, Christoph; Giannitsis, Evangelos; Searle, Julia.

in: AM J MED, Jahrgang 129, Nr. 3, 03.2016, S. 274-282.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Vafaie, M, Slagman, A, Möckel, M, Hamm, C, Huber, K, Müller, C, Vollert, JO, Blankenberg, S, Katus, HA, Liebetrau, C, Giannitsis, E & Searle, J 2016, 'Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome', AM J MED, Jg. 129, Nr. 3, S. 274-282. https://doi.org/10.1016/j.amjmed.2015.10.016

APA

Vafaie, M., Slagman, A., Möckel, M., Hamm, C., Huber, K., Müller, C., Vollert, J. O., Blankenberg, S., Katus, H. A., Liebetrau, C., Giannitsis, E., & Searle, J. (2016). Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome. AM J MED, 129(3), 274-282. https://doi.org/10.1016/j.amjmed.2015.10.016

Vancouver

Vafaie M, Slagman A, Möckel M, Hamm C, Huber K, Müller C et al. Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome. AM J MED. 2016 Mär;129(3):274-282. https://doi.org/10.1016/j.amjmed.2015.10.016

Bibtex

@article{926749fdcb4f4418881efc9221ab193a,
title = "Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome",
abstract = "BACKGROUND: The search for improved strategies for safe and early discharge of patients with suspected acute coronary syndrome in emergency departments is ongoing. This Biomarkers in Cardiology (BIC)-8 biomarker substudy evaluated the usefulness of high-sensitivity troponin T (hsTnT) below or above the limit of detection (LoD) in low-to-intermediate-risk patients with suspected acute coronary syndrome in the emergency department.METHODS: Patients were categorized into hsTnT ≥ the 99th percentile, between the 99th percentile and LoD, or undetectable hsTnT (<LoD). HsTnT and copeptin were measured at admission, using a copeptin cut-off of 10 pmol/L. The primary endpoint was death and myocardial infarction within 90 days after admission.RESULTS: Of 882 patients with all biomarker results, 577 (65.4%) had detectable hsTnT levels (≥LoD). Among the 305 patients (34.6%) with undetectable hsTnT, no myocardial infarctions or deaths occurred within 90 days. In patients with detectable hsTnT at admission (≥LoD but ≤99th percentile), the combined endpoint occurred in 1.5% (6/410) of the copeptin-negative patients and in 6.3% (6/96) of copeptin-positive patients within 90 days (hazard ratio 4.39; 95% confidence interval, 1.42-13.61; P = .01). In patients with an initially elevated hsTnT (≥14 ng/L), 9.7% (3/31) of the copeptin-negative patients and 15.4% (4/26) of the copeptin-positive patients experienced the combined endpoint (hazard ratio 1.61; 95% confidence interval, 0.36-7.17; P = .536).CONCLUSIONS: In low-to-intermediate-risk patients with suspected acute coronary syndrome, undetectable hsTnT values at admission allow a safe discharge without occurrence of death or myocardial infarction within 90 days.",
keywords = "Acute Coronary Syndrome/blood, Adult, Aged, Biomarkers/blood, Emergency Service, Hospital, Female, Glycopeptides/blood, Humans, Limit of Detection, Male, Middle Aged, Myocardial Infarction/epidemiology, Patient Admission, Prognosis, Troponin T/blood",
author = "Mehrshad Vafaie and Anna Slagman and Martin M{\"o}ckel and Christian Hamm and Kurt Huber and Christian M{\"u}ller and Vollert, {J{\"o}rn O} and Stefan Blankenberg and Katus, {Hugo A} and Christoph Liebetrau and Evangelos Giannitsis and Julia Searle",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = mar,
doi = "10.1016/j.amjmed.2015.10.016",
language = "English",
volume = "129",
pages = "274--282",
journal = "AM J MED",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Prognostic Value of Undetectable hs Troponin T in Suspected Acute Coronary Syndrome

AU - Vafaie, Mehrshad

AU - Slagman, Anna

AU - Möckel, Martin

AU - Hamm, Christian

AU - Huber, Kurt

AU - Müller, Christian

AU - Vollert, Jörn O

AU - Blankenberg, Stefan

AU - Katus, Hugo A

AU - Liebetrau, Christoph

AU - Giannitsis, Evangelos

AU - Searle, Julia

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND: The search for improved strategies for safe and early discharge of patients with suspected acute coronary syndrome in emergency departments is ongoing. This Biomarkers in Cardiology (BIC)-8 biomarker substudy evaluated the usefulness of high-sensitivity troponin T (hsTnT) below or above the limit of detection (LoD) in low-to-intermediate-risk patients with suspected acute coronary syndrome in the emergency department.METHODS: Patients were categorized into hsTnT ≥ the 99th percentile, between the 99th percentile and LoD, or undetectable hsTnT (<LoD). HsTnT and copeptin were measured at admission, using a copeptin cut-off of 10 pmol/L. The primary endpoint was death and myocardial infarction within 90 days after admission.RESULTS: Of 882 patients with all biomarker results, 577 (65.4%) had detectable hsTnT levels (≥LoD). Among the 305 patients (34.6%) with undetectable hsTnT, no myocardial infarctions or deaths occurred within 90 days. In patients with detectable hsTnT at admission (≥LoD but ≤99th percentile), the combined endpoint occurred in 1.5% (6/410) of the copeptin-negative patients and in 6.3% (6/96) of copeptin-positive patients within 90 days (hazard ratio 4.39; 95% confidence interval, 1.42-13.61; P = .01). In patients with an initially elevated hsTnT (≥14 ng/L), 9.7% (3/31) of the copeptin-negative patients and 15.4% (4/26) of the copeptin-positive patients experienced the combined endpoint (hazard ratio 1.61; 95% confidence interval, 0.36-7.17; P = .536).CONCLUSIONS: In low-to-intermediate-risk patients with suspected acute coronary syndrome, undetectable hsTnT values at admission allow a safe discharge without occurrence of death or myocardial infarction within 90 days.

AB - BACKGROUND: The search for improved strategies for safe and early discharge of patients with suspected acute coronary syndrome in emergency departments is ongoing. This Biomarkers in Cardiology (BIC)-8 biomarker substudy evaluated the usefulness of high-sensitivity troponin T (hsTnT) below or above the limit of detection (LoD) in low-to-intermediate-risk patients with suspected acute coronary syndrome in the emergency department.METHODS: Patients were categorized into hsTnT ≥ the 99th percentile, between the 99th percentile and LoD, or undetectable hsTnT (<LoD). HsTnT and copeptin were measured at admission, using a copeptin cut-off of 10 pmol/L. The primary endpoint was death and myocardial infarction within 90 days after admission.RESULTS: Of 882 patients with all biomarker results, 577 (65.4%) had detectable hsTnT levels (≥LoD). Among the 305 patients (34.6%) with undetectable hsTnT, no myocardial infarctions or deaths occurred within 90 days. In patients with detectable hsTnT at admission (≥LoD but ≤99th percentile), the combined endpoint occurred in 1.5% (6/410) of the copeptin-negative patients and in 6.3% (6/96) of copeptin-positive patients within 90 days (hazard ratio 4.39; 95% confidence interval, 1.42-13.61; P = .01). In patients with an initially elevated hsTnT (≥14 ng/L), 9.7% (3/31) of the copeptin-negative patients and 15.4% (4/26) of the copeptin-positive patients experienced the combined endpoint (hazard ratio 1.61; 95% confidence interval, 0.36-7.17; P = .536).CONCLUSIONS: In low-to-intermediate-risk patients with suspected acute coronary syndrome, undetectable hsTnT values at admission allow a safe discharge without occurrence of death or myocardial infarction within 90 days.

KW - Acute Coronary Syndrome/blood

KW - Adult

KW - Aged

KW - Biomarkers/blood

KW - Emergency Service, Hospital

KW - Female

KW - Glycopeptides/blood

KW - Humans

KW - Limit of Detection

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/epidemiology

KW - Patient Admission

KW - Prognosis

KW - Troponin T/blood

U2 - 10.1016/j.amjmed.2015.10.016

DO - 10.1016/j.amjmed.2015.10.016

M3 - SCORING: Journal article

C2 - 26524709

VL - 129

SP - 274

EP - 282

JO - AM J MED

JF - AM J MED

SN - 0002-9343

IS - 3

ER -