Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer
Standard
Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer. / Quhal, Fahad; Pradere, Benjamin; Sari Motlagh, Reza; Mori, Keiichiro; Laukhtina, Ekaterina; Aydh, Abdulmajeed; Mostafaei, Hadi; Lysenko, Ivan; Schuettfort, Victor M; Stolzenbach, Franziska; Palumbo, Carlotta; Heidenreich, Axel; Briganti, Alberto; Karakiewicz, Pierre I; Chlosta, Piotr; Shariat, Shahrokh F.
in: MINERVA UROL NEFROL, Jahrgang 73, Nr. 5, 10.2021, S. 610-615.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Prognostic value of preoperative albumin to globulin ratio in patients treated with salvage radical prostatectomy for radiation recurrent prostate cancer
AU - Quhal, Fahad
AU - Pradere, Benjamin
AU - Sari Motlagh, Reza
AU - Mori, Keiichiro
AU - Laukhtina, Ekaterina
AU - Aydh, Abdulmajeed
AU - Mostafaei, Hadi
AU - Lysenko, Ivan
AU - Schuettfort, Victor M
AU - Stolzenbach, Franziska
AU - Palumbo, Carlotta
AU - Heidenreich, Axel
AU - Briganti, Alberto
AU - Karakiewicz, Pierre I
AU - Chlosta, Piotr
AU - Shariat, Shahrokh F
PY - 2021/10
Y1 - 2021/10
N2 - BACKGROUND: Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed to evaluate the predictive value of preoperative AGR for oncological outcomes in patients with radiation recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).METHODS: A retrospective review of 214 consecutive patients with radiation-recurrent PCa who underwent SRP at five referral centers. Levels of albumin and globulin were obtained before SRP and used to calculate the preoperative AGR level. The optimal cut off value of preoperative AGR was 1.4. Univariable and multivariable Cox regression analyses were performed.RESULTS: Overall 89 (41.6%) patients had a low preoperative AGR. Low serum AGR was associated with biochemical recurrence (BCR) in univariable Cox regression analysis (HR 1.60, 95%CI 1.06-2.43, P=0.026). When adjusted for the effects of established preoperative and postoperative clinicopathologic confounders in different multivariable Cox regression models, this association did not retain its statistical significance. Moreover, preoperative AGR was not associated with metastasis free survival (P= 0.21), overall survival (P= 0.91) or cancer specific survival (P=0.61).CONCLUSIONS: In patients with radiation recurrent PCa undergoing SRP, low preoperative AGR was associated with the risk of BCR only in univariable analysis. There was no association with metastasis or survival outcomes. Further studies are needed to evaluate this biomarker in the setting of primary PCa and to identify the patients most likely to benefit from a local therapy.
AB - BACKGROUND: Serum albumin-to-globulin ratio (AGR) has been shown to be associated with poor prognosis in different malignancies. In this study we aimed to evaluate the predictive value of preoperative AGR for oncological outcomes in patients with radiation recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).METHODS: A retrospective review of 214 consecutive patients with radiation-recurrent PCa who underwent SRP at five referral centers. Levels of albumin and globulin were obtained before SRP and used to calculate the preoperative AGR level. The optimal cut off value of preoperative AGR was 1.4. Univariable and multivariable Cox regression analyses were performed.RESULTS: Overall 89 (41.6%) patients had a low preoperative AGR. Low serum AGR was associated with biochemical recurrence (BCR) in univariable Cox regression analysis (HR 1.60, 95%CI 1.06-2.43, P=0.026). When adjusted for the effects of established preoperative and postoperative clinicopathologic confounders in different multivariable Cox regression models, this association did not retain its statistical significance. Moreover, preoperative AGR was not associated with metastasis free survival (P= 0.21), overall survival (P= 0.91) or cancer specific survival (P=0.61).CONCLUSIONS: In patients with radiation recurrent PCa undergoing SRP, low preoperative AGR was associated with the risk of BCR only in univariable analysis. There was no association with metastasis or survival outcomes. Further studies are needed to evaluate this biomarker in the setting of primary PCa and to identify the patients most likely to benefit from a local therapy.
U2 - 10.23736/S2724-6051.20.03938-7
DO - 10.23736/S2724-6051.20.03938-7
M3 - SCORING: Journal article
C2 - 32993278
VL - 73
SP - 610
EP - 615
JO - MINERVA UROL NEFROL
JF - MINERVA UROL NEFROL
SN - 0393-2249
IS - 5
ER -
