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Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies

Standard

Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies. / Carcel, Cheryl; Sato, Shoichiro; Zheng, Danni; Heeley, Emma; Arima, Hisatomi; Yang, Jie; Wu, Guojun; Chen, Guofang; Zhang, Shihong; Delcourt, Candice; Lavados, Pablo; Robinson, Thompson; Lindley, Richard I; Wang, Xia; Chalmers, John; Anderson, Craig S; Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators.

in: CRIT CARE MED, Jahrgang 44, Nr. 7, 07.2016, S. 1388-94.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Carcel, C, Sato, S, Zheng, D, Heeley, E, Arima, H, Yang, J, Wu, G, Chen, G, Zhang, S, Delcourt, C, Lavados, P, Robinson, T, Lindley, RI, Wang, X, Chalmers, J, Anderson, CS & Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators 2016, 'Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies', CRIT CARE MED, Jg. 44, Nr. 7, S. 1388-94. https://doi.org/10.1097/CCM.0000000000001628

APA

Carcel, C., Sato, S., Zheng, D., Heeley, E., Arima, H., Yang, J., Wu, G., Chen, G., Zhang, S., Delcourt, C., Lavados, P., Robinson, T., Lindley, R. I., Wang, X., Chalmers, J., Anderson, C. S., & Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators (2016). Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies. CRIT CARE MED, 44(7), 1388-94. https://doi.org/10.1097/CCM.0000000000001628

Vancouver

Carcel C, Sato S, Zheng D, Heeley E, Arima H, Yang J et al. Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies. CRIT CARE MED. 2016 Jul;44(7):1388-94. https://doi.org/10.1097/CCM.0000000000001628

Bibtex

@article{20bd58df67ae4ee0908b566055d384d0,
title = "Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies",
abstract = "OBJECTIVES: To determine the association of hyponatremia at presentation with clinical and imaging outcomes in patients with acute intracerebral hemorrhage.DESIGN: Retrospective pooled analysis of prospectively collected data from 3,243 participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 (international, multicenter, open, blinded endpoint, randomized controlled trials designed to assess the effects of early intensive blood pressure lowering in patients with acute intracerebral hemorrhage).SETTING: Clinical hospital sites in 21 countries.PATIENTS: Patients with predominantly mild-moderate severity of spontaneous intracerebral hemorrhage within 6 hours of onset and elevated systolic blood pressure (150-220 mm Hg) were included in the study.INTERVENTIONS: Patients were assigned to receive intensive (target systolic blood pressure, < 140 mm Hg within 1 hr) or guideline-recommended (target systolic blood pressure, < 180 mm Hg) blood pressure-lowering therapy.MEASUREMENTS AND MAIN RESULTS: Presentation hyponatremia was defined as serum sodium less than 135 mEq/L. The primary outcome was death at 90 days. Multivariable logistic regression was used to assess the association of hyponatremia with important clinical events. Of 3,002 patients with available data, 349 (12%) had hyponatremia. Hyponatremia was associated with death (18% vs 11%; multivariable-adjusted odds ratio, 1.81; 95% CI, 1.28-2.57; p < 0.001) and larger baseline intracerebral hemorrhage volume (multivariable adjusted, p = 0.046) but not with baseline perihematomal edema volume nor with growth of intracerebral hemorrhage or perihematomal edema during the initial 24 hours.CONCLUSIONS: Hyponatremia at presentation is associated with increased mortality in patients with predominantly deep and modest volume intracerebral hemorrhage through mechanisms that seem independent of growth in intracerebral hemorrhage or perihematomal edema.",
keywords = "Journal Article",
author = "Cheryl Carcel and Shoichiro Sato and Danni Zheng and Emma Heeley and Hisatomi Arima and Jie Yang and Guojun Wu and Guofang Chen and Shihong Zhang and Candice Delcourt and Pablo Lavados and Thompson Robinson and Lindley, {Richard I} and Xia Wang and John Chalmers and Anderson, {Craig S} and {Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators} and G{\"o}tz Thomalla",
year = "2016",
month = jul,
doi = "10.1097/CCM.0000000000001628",
language = "English",
volume = "44",
pages = "1388--94",
journal = "CRIT CARE MED",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

RIS

TY - JOUR

T1 - Prognostic Significance of Hyponatremia in Acute Intracerebral Hemorrhage: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies

AU - Carcel, Cheryl

AU - Sato, Shoichiro

AU - Zheng, Danni

AU - Heeley, Emma

AU - Arima, Hisatomi

AU - Yang, Jie

AU - Wu, Guojun

AU - Chen, Guofang

AU - Zhang, Shihong

AU - Delcourt, Candice

AU - Lavados, Pablo

AU - Robinson, Thompson

AU - Lindley, Richard I

AU - Wang, Xia

AU - Chalmers, John

AU - Anderson, Craig S

AU - Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial 2 Investigators

AU - Thomalla, Götz

PY - 2016/7

Y1 - 2016/7

N2 - OBJECTIVES: To determine the association of hyponatremia at presentation with clinical and imaging outcomes in patients with acute intracerebral hemorrhage.DESIGN: Retrospective pooled analysis of prospectively collected data from 3,243 participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 (international, multicenter, open, blinded endpoint, randomized controlled trials designed to assess the effects of early intensive blood pressure lowering in patients with acute intracerebral hemorrhage).SETTING: Clinical hospital sites in 21 countries.PATIENTS: Patients with predominantly mild-moderate severity of spontaneous intracerebral hemorrhage within 6 hours of onset and elevated systolic blood pressure (150-220 mm Hg) were included in the study.INTERVENTIONS: Patients were assigned to receive intensive (target systolic blood pressure, < 140 mm Hg within 1 hr) or guideline-recommended (target systolic blood pressure, < 180 mm Hg) blood pressure-lowering therapy.MEASUREMENTS AND MAIN RESULTS: Presentation hyponatremia was defined as serum sodium less than 135 mEq/L. The primary outcome was death at 90 days. Multivariable logistic regression was used to assess the association of hyponatremia with important clinical events. Of 3,002 patients with available data, 349 (12%) had hyponatremia. Hyponatremia was associated with death (18% vs 11%; multivariable-adjusted odds ratio, 1.81; 95% CI, 1.28-2.57; p < 0.001) and larger baseline intracerebral hemorrhage volume (multivariable adjusted, p = 0.046) but not with baseline perihematomal edema volume nor with growth of intracerebral hemorrhage or perihematomal edema during the initial 24 hours.CONCLUSIONS: Hyponatremia at presentation is associated with increased mortality in patients with predominantly deep and modest volume intracerebral hemorrhage through mechanisms that seem independent of growth in intracerebral hemorrhage or perihematomal edema.

AB - OBJECTIVES: To determine the association of hyponatremia at presentation with clinical and imaging outcomes in patients with acute intracerebral hemorrhage.DESIGN: Retrospective pooled analysis of prospectively collected data from 3,243 participants of the pilot and main phases of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials 1 and 2 (international, multicenter, open, blinded endpoint, randomized controlled trials designed to assess the effects of early intensive blood pressure lowering in patients with acute intracerebral hemorrhage).SETTING: Clinical hospital sites in 21 countries.PATIENTS: Patients with predominantly mild-moderate severity of spontaneous intracerebral hemorrhage within 6 hours of onset and elevated systolic blood pressure (150-220 mm Hg) were included in the study.INTERVENTIONS: Patients were assigned to receive intensive (target systolic blood pressure, < 140 mm Hg within 1 hr) or guideline-recommended (target systolic blood pressure, < 180 mm Hg) blood pressure-lowering therapy.MEASUREMENTS AND MAIN RESULTS: Presentation hyponatremia was defined as serum sodium less than 135 mEq/L. The primary outcome was death at 90 days. Multivariable logistic regression was used to assess the association of hyponatremia with important clinical events. Of 3,002 patients with available data, 349 (12%) had hyponatremia. Hyponatremia was associated with death (18% vs 11%; multivariable-adjusted odds ratio, 1.81; 95% CI, 1.28-2.57; p < 0.001) and larger baseline intracerebral hemorrhage volume (multivariable adjusted, p = 0.046) but not with baseline perihematomal edema volume nor with growth of intracerebral hemorrhage or perihematomal edema during the initial 24 hours.CONCLUSIONS: Hyponatremia at presentation is associated with increased mortality in patients with predominantly deep and modest volume intracerebral hemorrhage through mechanisms that seem independent of growth in intracerebral hemorrhage or perihematomal edema.

KW - Journal Article

U2 - 10.1097/CCM.0000000000001628

DO - 10.1097/CCM.0000000000001628

M3 - SCORING: Journal article

C2 - 26958746

VL - 44

SP - 1388

EP - 1394

JO - CRIT CARE MED

JF - CRIT CARE MED

SN - 0090-3493

IS - 7

ER -