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Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent

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Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent. / Mbeutcha, Aurélie; Lucca, Ilaria; Margulis, Vitaly; Karam, Jose A; Wood, Christopher G; de Martino, Michela; Mathieu, Romain; Haitel, Andrea; Xylinas, Evanguelos; Kluth, Luis; Rouprêt, Morgan; Karakiewicz, Pierre I; Briganti, Alberto; Rink, Michael; Rieken, Malte; Weizer, Alon Z; Raman, Jay D; Rioux-Leclecq, Nathalie; Bolenz, Christian; Bensalah, Karim; Lotan, Yair; Seitz, Christian; Remzi, Mesut; Shariat, Shahrokh F; Klatte, Tobias.

in: WORLD J UROL, Jahrgang 34, Nr. 8, 01.08.2016, S. 1155-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mbeutcha, A, Lucca, I, Margulis, V, Karam, JA, Wood, CG, de Martino, M, Mathieu, R, Haitel, A, Xylinas, E, Kluth, L, Rouprêt, M, Karakiewicz, PI, Briganti, A, Rink, M, Rieken, M, Weizer, AZ, Raman, JD, Rioux-Leclecq, N, Bolenz, C, Bensalah, K, Lotan, Y, Seitz, C, Remzi, M, Shariat, SF & Klatte, T 2016, 'Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent', WORLD J UROL, Jg. 34, Nr. 8, S. 1155-61. https://doi.org/10.1007/s00345-015-1737-7

APA

Mbeutcha, A., Lucca, I., Margulis, V., Karam, J. A., Wood, C. G., de Martino, M., Mathieu, R., Haitel, A., Xylinas, E., Kluth, L., Rouprêt, M., Karakiewicz, P. I., Briganti, A., Rink, M., Rieken, M., Weizer, A. Z., Raman, J. D., Rioux-Leclecq, N., Bolenz, C., ... Klatte, T. (2016). Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent. WORLD J UROL, 34(8), 1155-61. https://doi.org/10.1007/s00345-015-1737-7

Vancouver

Mbeutcha A, Lucca I, Margulis V, Karam JA, Wood CG, de Martino M et al. Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent. WORLD J UROL. 2016 Aug 1;34(8):1155-61. https://doi.org/10.1007/s00345-015-1737-7

Bibtex

@article{3c98413abe624bbd8d9396fff8c06f7a,
title = "Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent",
abstract = "BACKGROUND: Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.RESULTS: ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).CONCLUSIONS: ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.",
author = "Aur{\'e}lie Mbeutcha and Ilaria Lucca and Vitaly Margulis and Karam, {Jose A} and Wood, {Christopher G} and {de Martino}, Michela and Romain Mathieu and Andrea Haitel and Evanguelos Xylinas and Luis Kluth and Morgan Roupr{\^e}t and Karakiewicz, {Pierre I} and Alberto Briganti and Michael Rink and Malte Rieken and Weizer, {Alon Z} and Raman, {Jay D} and Nathalie Rioux-Leclecq and Christian Bolenz and Karim Bensalah and Yair Lotan and Christian Seitz and Mesut Remzi and Shariat, {Shahrokh F} and Tobias Klatte",
year = "2016",
month = aug,
day = "1",
doi = "10.1007/s00345-015-1737-7",
language = "English",
volume = "34",
pages = "1155--61",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "8",

}

RIS

TY - JOUR

T1 - Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent

AU - Mbeutcha, Aurélie

AU - Lucca, Ilaria

AU - Margulis, Vitaly

AU - Karam, Jose A

AU - Wood, Christopher G

AU - de Martino, Michela

AU - Mathieu, Romain

AU - Haitel, Andrea

AU - Xylinas, Evanguelos

AU - Kluth, Luis

AU - Rouprêt, Morgan

AU - Karakiewicz, Pierre I

AU - Briganti, Alberto

AU - Rink, Michael

AU - Rieken, Malte

AU - Weizer, Alon Z

AU - Raman, Jay D

AU - Rioux-Leclecq, Nathalie

AU - Bolenz, Christian

AU - Bensalah, Karim

AU - Lotan, Yair

AU - Seitz, Christian

AU - Remzi, Mesut

AU - Shariat, Shahrokh F

AU - Klatte, Tobias

PY - 2016/8/1

Y1 - 2016/8/1

N2 - BACKGROUND: Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.RESULTS: ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).CONCLUSIONS: ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.

AB - BACKGROUND: Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients.METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was >1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models.RESULTS: ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively).CONCLUSIONS: ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy.

U2 - 10.1007/s00345-015-1737-7

DO - 10.1007/s00345-015-1737-7

M3 - SCORING: Journal article

C2 - 26658888

VL - 34

SP - 1155

EP - 1161

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 8

ER -