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Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium

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Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium. / Bachmayr-Heyda, Anna; Aust, Stefanie; Heinze, Georg; Polterauer, Stephan; Grimm, Christoph; Braicu, Elena Ioana; Sehouli, Jalid; Lambrechts, Sandrina; Vergote, Ignace; Mahner, Sven; Pils, Dietmar; Schuster, Eva; Thalhammer, Theresia; Horvat, Reinhard; Denkert, Carsten; Zeillinger, Robert; Castillo-Tong, Dan Cacsire.

in: BMC CANCER, Jahrgang 13, 01.01.2013, S. 422.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bachmayr-Heyda, A, Aust, S, Heinze, G, Polterauer, S, Grimm, C, Braicu, EI, Sehouli, J, Lambrechts, S, Vergote, I, Mahner, S, Pils, D, Schuster, E, Thalhammer, T, Horvat, R, Denkert, C, Zeillinger, R & Castillo-Tong, DC 2013, 'Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium', BMC CANCER, Jg. 13, S. 422. https://doi.org/10.1186/1471-2407-13-422

APA

Bachmayr-Heyda, A., Aust, S., Heinze, G., Polterauer, S., Grimm, C., Braicu, E. I., Sehouli, J., Lambrechts, S., Vergote, I., Mahner, S., Pils, D., Schuster, E., Thalhammer, T., Horvat, R., Denkert, C., Zeillinger, R., & Castillo-Tong, D. C. (2013). Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium. BMC CANCER, 13, 422. https://doi.org/10.1186/1471-2407-13-422

Vancouver

Bachmayr-Heyda A, Aust S, Heinze G, Polterauer S, Grimm C, Braicu EI et al. Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium. BMC CANCER. 2013 Jan 1;13:422. https://doi.org/10.1186/1471-2407-13-422

Bibtex

@article{7acd1733c4d848bbacb25b13c6cd946b,
title = "Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium",
abstract = "BACKGROUND: Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we assessed tumor infiltrating CD8+ T cells in association with Ki67 proliferation index and evaluated their prognostic impact in EOC samples.METHODS: CD8+ cells and Ki67 proliferation index were immunohistochemically determined on tissue microarrays including 203 primary epithelial ovarian tumors. Additionally, CD8 gene expression was assessed with RT-qPCR. Correlations were analyzed using Pearson's correlation coefficients, ANOVA or T-test, or Fischer's exact tests. Prognostic impact was evaluated using the Kaplan-Meier method and Cox regression model.RESULTS: The density of CD8+ infiltrating lymphocytes did not correlate with tumor cell proliferation. Epithelial ovarian cancer patients with no Ki67+ cells in the tumor had a more than three times higher risk to die compared to the population with Ki67+ cells in the tumor (Hazard ratio (HR) = 3.34, 95%CI 1.59-7.04). High CD8+ cell infiltration was associated with improved overall survival (HR = 0.82, 95%CI 0.73-0.92).CONCLUSIONS: The density of tumor infiltrating lymphocytes is independent of tumor cell proliferation. Ovarian cancer patients with Ki67- tumors showed a significantly reduced overall survival, presumably due to no or poor response to platinum-based chemotherapy. Moreover, the association of high densities of tumor infiltrating cytotoxic T lymphocytes with a better overall survival was confirmed.",
author = "Anna Bachmayr-Heyda and Stefanie Aust and Georg Heinze and Stephan Polterauer and Christoph Grimm and Braicu, {Elena Ioana} and Jalid Sehouli and Sandrina Lambrechts and Ignace Vergote and Sven Mahner and Dietmar Pils and Eva Schuster and Theresia Thalhammer and Reinhard Horvat and Carsten Denkert and Robert Zeillinger and Castillo-Tong, {Dan Cacsire}",
year = "2013",
month = jan,
day = "1",
doi = "10.1186/1471-2407-13-422",
language = "English",
volume = "13",
pages = "422",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients--a study of the OVCAD consortium

AU - Bachmayr-Heyda, Anna

AU - Aust, Stefanie

AU - Heinze, Georg

AU - Polterauer, Stephan

AU - Grimm, Christoph

AU - Braicu, Elena Ioana

AU - Sehouli, Jalid

AU - Lambrechts, Sandrina

AU - Vergote, Ignace

AU - Mahner, Sven

AU - Pils, Dietmar

AU - Schuster, Eva

AU - Thalhammer, Theresia

AU - Horvat, Reinhard

AU - Denkert, Carsten

AU - Zeillinger, Robert

AU - Castillo-Tong, Dan Cacsire

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we assessed tumor infiltrating CD8+ T cells in association with Ki67 proliferation index and evaluated their prognostic impact in EOC samples.METHODS: CD8+ cells and Ki67 proliferation index were immunohistochemically determined on tissue microarrays including 203 primary epithelial ovarian tumors. Additionally, CD8 gene expression was assessed with RT-qPCR. Correlations were analyzed using Pearson's correlation coefficients, ANOVA or T-test, or Fischer's exact tests. Prognostic impact was evaluated using the Kaplan-Meier method and Cox regression model.RESULTS: The density of CD8+ infiltrating lymphocytes did not correlate with tumor cell proliferation. Epithelial ovarian cancer patients with no Ki67+ cells in the tumor had a more than three times higher risk to die compared to the population with Ki67+ cells in the tumor (Hazard ratio (HR) = 3.34, 95%CI 1.59-7.04). High CD8+ cell infiltration was associated with improved overall survival (HR = 0.82, 95%CI 0.73-0.92).CONCLUSIONS: The density of tumor infiltrating lymphocytes is independent of tumor cell proliferation. Ovarian cancer patients with Ki67- tumors showed a significantly reduced overall survival, presumably due to no or poor response to platinum-based chemotherapy. Moreover, the association of high densities of tumor infiltrating cytotoxic T lymphocytes with a better overall survival was confirmed.

AB - BACKGROUND: Epithelial ovarian cancer is one of the most lethal gynecologic malignancies. Clinicopathological factors do not permit precise prognosis and cannot provide guidance to specific treatments. In this study we assessed tumor infiltrating CD8+ T cells in association with Ki67 proliferation index and evaluated their prognostic impact in EOC samples.METHODS: CD8+ cells and Ki67 proliferation index were immunohistochemically determined on tissue microarrays including 203 primary epithelial ovarian tumors. Additionally, CD8 gene expression was assessed with RT-qPCR. Correlations were analyzed using Pearson's correlation coefficients, ANOVA or T-test, or Fischer's exact tests. Prognostic impact was evaluated using the Kaplan-Meier method and Cox regression model.RESULTS: The density of CD8+ infiltrating lymphocytes did not correlate with tumor cell proliferation. Epithelial ovarian cancer patients with no Ki67+ cells in the tumor had a more than three times higher risk to die compared to the population with Ki67+ cells in the tumor (Hazard ratio (HR) = 3.34, 95%CI 1.59-7.04). High CD8+ cell infiltration was associated with improved overall survival (HR = 0.82, 95%CI 0.73-0.92).CONCLUSIONS: The density of tumor infiltrating lymphocytes is independent of tumor cell proliferation. Ovarian cancer patients with Ki67- tumors showed a significantly reduced overall survival, presumably due to no or poor response to platinum-based chemotherapy. Moreover, the association of high densities of tumor infiltrating cytotoxic T lymphocytes with a better overall survival was confirmed.

U2 - 10.1186/1471-2407-13-422

DO - 10.1186/1471-2407-13-422

M3 - SCORING: Journal article

C2 - 24044611

VL - 13

SP - 422

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -