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Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series

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Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series. / May, Matthias; Aziz, Atiqullah; Brookman-May, Sabine; Roghmann, Florian; Noldus, Joachim; Rink, Michael; Chun, Felix; Fisch, Margit; Novotny, Vladimir; Wirth, Manfred; Mayr, Roman; Pycha, Armin; Brisuda, Antonin; Volkmer, Björn; Stredele, Regina; Dechet, Christopher; Vallo, Stefan; Haferkamp, Axel; Schnabel, Marco; Denzinger, Stefan; Roigas, Jan; Stief, Christian G; Gilfrich, Christian; Bastian, Patrick J; Engel, Jörg B; Burger, Maximilian; Fritsche, Hans-Martin.

in: WORLD J UROL, Jahrgang 33, Nr. 3, 01.03.2014, S. 343-350.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

May, M, Aziz, A, Brookman-May, S, Roghmann, F, Noldus, J, Rink, M, Chun, F, Fisch, M, Novotny, V, Wirth, M, Mayr, R, Pycha, A, Brisuda, A, Volkmer, B, Stredele, R, Dechet, C, Vallo, S, Haferkamp, A, Schnabel, M, Denzinger, S, Roigas, J, Stief, CG, Gilfrich, C, Bastian, PJ, Engel, JB, Burger, M & Fritsche, H-M 2014, 'Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series', WORLD J UROL, Jg. 33, Nr. 3, S. 343-350. https://doi.org/10.1007/s00345-014-1308-3

APA

May, M., Aziz, A., Brookman-May, S., Roghmann, F., Noldus, J., Rink, M., Chun, F., Fisch, M., Novotny, V., Wirth, M., Mayr, R., Pycha, A., Brisuda, A., Volkmer, B., Stredele, R., Dechet, C., Vallo, S., Haferkamp, A., Schnabel, M., ... Fritsche, H-M. (2014). Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series. WORLD J UROL, 33(3), 343-350. https://doi.org/10.1007/s00345-014-1308-3

Vancouver

May M, Aziz A, Brookman-May S, Roghmann F, Noldus J, Rink M et al. Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series. WORLD J UROL. 2014 Mär 1;33(3):343-350. https://doi.org/10.1007/s00345-014-1308-3

Bibtex

@article{f0a2d3db44a540d1bcdac25ce6beb81e,
title = "Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series",
abstract = "PURPOSE: To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration.PATIENTS AND METHODS: Our series comprised of 92 female patients in total of whom 87 with known invasion patterns were eligible for final analysis. Median follow-up for evaluation of cancer-specific mortality (CSM) was 38 months (interquartile ranges, 21-82 months). The impact on CSM was evaluated using multivariable Cox proportional-hazards regression analysis; predictive accuracy (PA) was assessed by receiver operating characteristic analysis.RESULTS: Vaginal invasion was noted in 33 patients (37.9 %; group VAG), uterine invasion in 20 patients (23 %; group UT), and infiltration of both vagina and uterus in 34 patients (39.1 %; group VAG + UT). Groups VAG and UT significantly differed from group VAG + UT with regard to the presence of positive soft tissue margins (STM) only. Five-year-cancer-specific survival probabilities in the groups VAG, UT, and VAG + UT were 21, 20, and 21 %, respectively (p = 0.955). On multivariable analysis, only STM status (HR = 2.02, p = 0.023) independently influenced CSM. C-indices of multivariable models for CSM with and without integration of invasive patterns were 0.570 and 0.567, respectively (PA gain 0.3 %, p = 0.526).CONCLUSIONS: Infiltration of the vagina, the uterus or both is associated with poor 5-year survival rates. With regard to CSM, no difference was detectable between patients with different invasion patterns, thus justifying further collectively including these invasive patterns as stage pT4a.",
author = "Matthias May and Atiqullah Aziz and Sabine Brookman-May and Florian Roghmann and Joachim Noldus and Michael Rink and Felix Chun and Margit Fisch and Vladimir Novotny and Manfred Wirth and Roman Mayr and Armin Pycha and Antonin Brisuda and Bj{\"o}rn Volkmer and Regina Stredele and Christopher Dechet and Stefan Vallo and Axel Haferkamp and Marco Schnabel and Stefan Denzinger and Jan Roigas and Stief, {Christian G} and Christian Gilfrich and Bastian, {Patrick J} and Engel, {J{\"o}rg B} and Maximilian Burger and Hans-Martin Fritsche",
year = "2014",
month = mar,
day = "1",
doi = "10.1007/s00345-014-1308-3",
language = "English",
volume = "33",
pages = "343--350",
journal = "WORLD J UROL",
issn = "0724-4983",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series

AU - May, Matthias

AU - Aziz, Atiqullah

AU - Brookman-May, Sabine

AU - Roghmann, Florian

AU - Noldus, Joachim

AU - Rink, Michael

AU - Chun, Felix

AU - Fisch, Margit

AU - Novotny, Vladimir

AU - Wirth, Manfred

AU - Mayr, Roman

AU - Pycha, Armin

AU - Brisuda, Antonin

AU - Volkmer, Björn

AU - Stredele, Regina

AU - Dechet, Christopher

AU - Vallo, Stefan

AU - Haferkamp, Axel

AU - Schnabel, Marco

AU - Denzinger, Stefan

AU - Roigas, Jan

AU - Stief, Christian G

AU - Gilfrich, Christian

AU - Bastian, Patrick J

AU - Engel, Jörg B

AU - Burger, Maximilian

AU - Fritsche, Hans-Martin

PY - 2014/3/1

Y1 - 2014/3/1

N2 - PURPOSE: To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration.PATIENTS AND METHODS: Our series comprised of 92 female patients in total of whom 87 with known invasion patterns were eligible for final analysis. Median follow-up for evaluation of cancer-specific mortality (CSM) was 38 months (interquartile ranges, 21-82 months). The impact on CSM was evaluated using multivariable Cox proportional-hazards regression analysis; predictive accuracy (PA) was assessed by receiver operating characteristic analysis.RESULTS: Vaginal invasion was noted in 33 patients (37.9 %; group VAG), uterine invasion in 20 patients (23 %; group UT), and infiltration of both vagina and uterus in 34 patients (39.1 %; group VAG + UT). Groups VAG and UT significantly differed from group VAG + UT with regard to the presence of positive soft tissue margins (STM) only. Five-year-cancer-specific survival probabilities in the groups VAG, UT, and VAG + UT were 21, 20, and 21 %, respectively (p = 0.955). On multivariable analysis, only STM status (HR = 2.02, p = 0.023) independently influenced CSM. C-indices of multivariable models for CSM with and without integration of invasive patterns were 0.570 and 0.567, respectively (PA gain 0.3 %, p = 0.526).CONCLUSIONS: Infiltration of the vagina, the uterus or both is associated with poor 5-year survival rates. With regard to CSM, no difference was detectable between patients with different invasion patterns, thus justifying further collectively including these invasive patterns as stage pT4a.

AB - PURPOSE: To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration.PATIENTS AND METHODS: Our series comprised of 92 female patients in total of whom 87 with known invasion patterns were eligible for final analysis. Median follow-up for evaluation of cancer-specific mortality (CSM) was 38 months (interquartile ranges, 21-82 months). The impact on CSM was evaluated using multivariable Cox proportional-hazards regression analysis; predictive accuracy (PA) was assessed by receiver operating characteristic analysis.RESULTS: Vaginal invasion was noted in 33 patients (37.9 %; group VAG), uterine invasion in 20 patients (23 %; group UT), and infiltration of both vagina and uterus in 34 patients (39.1 %; group VAG + UT). Groups VAG and UT significantly differed from group VAG + UT with regard to the presence of positive soft tissue margins (STM) only. Five-year-cancer-specific survival probabilities in the groups VAG, UT, and VAG + UT were 21, 20, and 21 %, respectively (p = 0.955). On multivariable analysis, only STM status (HR = 2.02, p = 0.023) independently influenced CSM. C-indices of multivariable models for CSM with and without integration of invasive patterns were 0.570 and 0.567, respectively (PA gain 0.3 %, p = 0.526).CONCLUSIONS: Infiltration of the vagina, the uterus or both is associated with poor 5-year survival rates. With regard to CSM, no difference was detectable between patients with different invasion patterns, thus justifying further collectively including these invasive patterns as stage pT4a.

U2 - 10.1007/s00345-014-1308-3

DO - 10.1007/s00345-014-1308-3

M3 - SCORING: Journal article

C2 - 24817140

VL - 33

SP - 343

EP - 350

JO - WORLD J UROL

JF - WORLD J UROL

SN - 0724-4983

IS - 3

ER -