Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.
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Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. / Thol, Felicitas; Damm, Frederik; Wagner, Katharina; Göhring, Gudrun; Schlegelberger, Brigitte; Hoelzer, Dieter; Lübbert, Michael; Heit, Wolfgang; Kanz, Lothar; Schlimok, Günter; Raghavachar, Aruna; Fiedler, Walter; Kirchner, Hartmut; Heil, Gerhard; Heuser, Michael; Krauter, Jürgen; Ganser, Arnold.
in: BLOOD, Jahrgang 116, Nr. 4, 4, 2010, S. 614-616.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia.
AU - Thol, Felicitas
AU - Damm, Frederik
AU - Wagner, Katharina
AU - Göhring, Gudrun
AU - Schlegelberger, Brigitte
AU - Hoelzer, Dieter
AU - Lübbert, Michael
AU - Heit, Wolfgang
AU - Kanz, Lothar
AU - Schlimok, Günter
AU - Raghavachar, Aruna
AU - Fiedler, Walter
AU - Kirchner, Hartmut
AU - Heil, Gerhard
AU - Heuser, Michael
AU - Krauter, Jürgen
AU - Ganser, Arnold
PY - 2010
Y1 - 2010
N2 - Mutations in the nicotinamide adenine dinucleotide phosphate(+)-dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute myeloid leukemia (AML) as well as in patients with leukemic transformation of myeloproliferative neoplasms. We analyzed 272 adult patients with cytogenetically normal AML (CN-AML) for the presence of IDH2 mutations in codons R140 and R172. IDH2 mutations of amino acid 140 or 172 could be identified in 12.1% of CN-AML patients, with the majority of mutations (90%) occurring at position R140. The incidence of IDH2 mutations in AML patients with aberrant karyotypes (n = 130) was significantly lower (3.8%, P = .006). IDH2 mutations were mutually exclusive with mutations in IDH1. IDH2 mutation status alone or in combination with IDH1 mutations had no impact on response to therapy, overall survival, and relapse-free survival in patients with CN-AML. In conclusion, IDH2 mutations are frequently found in CN-AML, but in our analysis these mutations did not influence treatment outcome. This study was registered at www.clinicaltrials.gov as #NCT00209833.
AB - Mutations in the nicotinamide adenine dinucleotide phosphate(+)-dependent isocitrate dehydrogenase gene 2 (IDH2) have recently been found in patients with acute myeloid leukemia (AML) as well as in patients with leukemic transformation of myeloproliferative neoplasms. We analyzed 272 adult patients with cytogenetically normal AML (CN-AML) for the presence of IDH2 mutations in codons R140 and R172. IDH2 mutations of amino acid 140 or 172 could be identified in 12.1% of CN-AML patients, with the majority of mutations (90%) occurring at position R140. The incidence of IDH2 mutations in AML patients with aberrant karyotypes (n = 130) was significantly lower (3.8%, P = .006). IDH2 mutations were mutually exclusive with mutations in IDH1. IDH2 mutation status alone or in combination with IDH1 mutations had no impact on response to therapy, overall survival, and relapse-free survival in patients with CN-AML. In conclusion, IDH2 mutations are frequently found in CN-AML, but in our analysis these mutations did not influence treatment outcome. This study was registered at www.clinicaltrials.gov as #NCT00209833.
M3 - SCORING: Zeitschriftenaufsatz
VL - 116
SP - 614
EP - 616
JO - BLOOD
JF - BLOOD
SN - 0006-4971
IS - 4
M1 - 4
ER -
