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Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis

Standard

Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis. / Passoni, Niccolo M; Fajkovic, Harun; Xylinas, Evanguelos; Kluth, Luis; Seitz, Christian; Robinson, Brian D; Rouprêt, Morgan; Chun, Felix K; Lotan, Yair; Roehrborn, Claus G; Crivelli, Joseph J; Karakiewicz, Pierre I; Scherr, Douglas S; Rink, Michael; Graefen, Markus; Schramek, Paul; Briganti, Alberto; Montorsi, Francesco; Tewari, Ashutosh; Shariat, Shahrokh F.

in: BJU INT, Jahrgang 114, Nr. 4, 01.10.2014, S. 503-510.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Passoni, NM, Fajkovic, H, Xylinas, E, Kluth, L, Seitz, C, Robinson, BD, Rouprêt, M, Chun, FK, Lotan, Y, Roehrborn, CG, Crivelli, JJ, Karakiewicz, PI, Scherr, DS, Rink, M, Graefen, M, Schramek, P, Briganti, A, Montorsi, F, Tewari, A & Shariat, SF 2014, 'Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis', BJU INT, Jg. 114, Nr. 4, S. 503-510. https://doi.org/10.1111/bju.12342

APA

Passoni, N. M., Fajkovic, H., Xylinas, E., Kluth, L., Seitz, C., Robinson, B. D., Rouprêt, M., Chun, F. K., Lotan, Y., Roehrborn, C. G., Crivelli, J. J., Karakiewicz, P. I., Scherr, D. S., Rink, M., Graefen, M., Schramek, P., Briganti, A., Montorsi, F., Tewari, A., & Shariat, S. F. (2014). Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis. BJU INT, 114(4), 503-510. https://doi.org/10.1111/bju.12342

Vancouver

Passoni NM, Fajkovic H, Xylinas E, Kluth L, Seitz C, Robinson BD et al. Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis. BJU INT. 2014 Okt 1;114(4):503-510. https://doi.org/10.1111/bju.12342

Bibtex

@article{9a5281dafaeb400cbc8605cf1aad06ed,
title = "Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis",
abstract = "OBJECTIVE: To assess the prognostic role of extranodal extension (ENE) and the size of the largest lymph node (LN) metastasis in predicting early biochemical relapse (eBCR) in patients with LN metastasis after radical prostatectomy (RP).PATIENTS AND METHODS: We evaluated BCR-free survival in men with LN metastases after RP and pelvic LN dissection performed in six high-volume centres. Multivariable Cox regression tested the role of ENE and diameter of largest LN metastasis in predicting eBCR after adjusting for clinicopathological variables. We compared the discrimination of multivariable models including ENE, the size of largest LN metastasis and the number of positive LNs.RESULTS: Overall, 484 patients were included. The median (interquartile range, IQR) follow-up was 16.1 (6-27.5) months. The median (IQR) number of removed LNs was 10 (4-14), and the median (IQR) number of positive LNs was 1 (1-2). ENE was present in 280 (58%) patients, and 211 (44%) had their largest metastasis >10 mm. Patients with ENE and/or largest metastasis of >10 mm had significantly worse eBCR-free survival (all P < 0.01). On multivariable analysis, number of positive LNs (≤2 vs >2) and the diameter of LN metastasis (≤10 vs >10 mm), but not ENE, were significant predictors of eBCR (all P < 0.003). ENE and diameter of LN metastasis increased the area under the curve of a baseline multivariable model (0.663) by 0.016 points.CONCLUSIONS: The diameter of the largest LN metastasis and the number of positive LNs are independent predictors of eBCR. Considered together, ENE and the diameter of the largest LN metastasis have less discrimination than the number of positive LNs.",
author = "Passoni, {Niccolo M} and Harun Fajkovic and Evanguelos Xylinas and Luis Kluth and Christian Seitz and Robinson, {Brian D} and Morgan Roupr{\^e}t and Chun, {Felix K} and Yair Lotan and Roehrborn, {Claus G} and Crivelli, {Joseph J} and Karakiewicz, {Pierre I} and Scherr, {Douglas S} and Michael Rink and Markus Graefen and Paul Schramek and Alberto Briganti and Francesco Montorsi and Ashutosh Tewari and Shariat, {Shahrokh F}",
note = "{\textcopyright} 2013 The Authors. BJU International {\textcopyright} 2013 BJU International.",
year = "2014",
month = oct,
day = "1",
doi = "10.1111/bju.12342",
language = "English",
volume = "114",
pages = "503--510",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Prognosis of patients with pelvic lymph node (LN) metastasis after radical prostatectomy: Value of extranodal extension and size of the largest LN metastasis

AU - Passoni, Niccolo M

AU - Fajkovic, Harun

AU - Xylinas, Evanguelos

AU - Kluth, Luis

AU - Seitz, Christian

AU - Robinson, Brian D

AU - Rouprêt, Morgan

AU - Chun, Felix K

AU - Lotan, Yair

AU - Roehrborn, Claus G

AU - Crivelli, Joseph J

AU - Karakiewicz, Pierre I

AU - Scherr, Douglas S

AU - Rink, Michael

AU - Graefen, Markus

AU - Schramek, Paul

AU - Briganti, Alberto

AU - Montorsi, Francesco

AU - Tewari, Ashutosh

AU - Shariat, Shahrokh F

N1 - © 2013 The Authors. BJU International © 2013 BJU International.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - OBJECTIVE: To assess the prognostic role of extranodal extension (ENE) and the size of the largest lymph node (LN) metastasis in predicting early biochemical relapse (eBCR) in patients with LN metastasis after radical prostatectomy (RP).PATIENTS AND METHODS: We evaluated BCR-free survival in men with LN metastases after RP and pelvic LN dissection performed in six high-volume centres. Multivariable Cox regression tested the role of ENE and diameter of largest LN metastasis in predicting eBCR after adjusting for clinicopathological variables. We compared the discrimination of multivariable models including ENE, the size of largest LN metastasis and the number of positive LNs.RESULTS: Overall, 484 patients were included. The median (interquartile range, IQR) follow-up was 16.1 (6-27.5) months. The median (IQR) number of removed LNs was 10 (4-14), and the median (IQR) number of positive LNs was 1 (1-2). ENE was present in 280 (58%) patients, and 211 (44%) had their largest metastasis >10 mm. Patients with ENE and/or largest metastasis of >10 mm had significantly worse eBCR-free survival (all P < 0.01). On multivariable analysis, number of positive LNs (≤2 vs >2) and the diameter of LN metastasis (≤10 vs >10 mm), but not ENE, were significant predictors of eBCR (all P < 0.003). ENE and diameter of LN metastasis increased the area under the curve of a baseline multivariable model (0.663) by 0.016 points.CONCLUSIONS: The diameter of the largest LN metastasis and the number of positive LNs are independent predictors of eBCR. Considered together, ENE and the diameter of the largest LN metastasis have less discrimination than the number of positive LNs.

AB - OBJECTIVE: To assess the prognostic role of extranodal extension (ENE) and the size of the largest lymph node (LN) metastasis in predicting early biochemical relapse (eBCR) in patients with LN metastasis after radical prostatectomy (RP).PATIENTS AND METHODS: We evaluated BCR-free survival in men with LN metastases after RP and pelvic LN dissection performed in six high-volume centres. Multivariable Cox regression tested the role of ENE and diameter of largest LN metastasis in predicting eBCR after adjusting for clinicopathological variables. We compared the discrimination of multivariable models including ENE, the size of largest LN metastasis and the number of positive LNs.RESULTS: Overall, 484 patients were included. The median (interquartile range, IQR) follow-up was 16.1 (6-27.5) months. The median (IQR) number of removed LNs was 10 (4-14), and the median (IQR) number of positive LNs was 1 (1-2). ENE was present in 280 (58%) patients, and 211 (44%) had their largest metastasis >10 mm. Patients with ENE and/or largest metastasis of >10 mm had significantly worse eBCR-free survival (all P < 0.01). On multivariable analysis, number of positive LNs (≤2 vs >2) and the diameter of LN metastasis (≤10 vs >10 mm), but not ENE, were significant predictors of eBCR (all P < 0.003). ENE and diameter of LN metastasis increased the area under the curve of a baseline multivariable model (0.663) by 0.016 points.CONCLUSIONS: The diameter of the largest LN metastasis and the number of positive LNs are independent predictors of eBCR. Considered together, ENE and the diameter of the largest LN metastasis have less discrimination than the number of positive LNs.

U2 - 10.1111/bju.12342

DO - 10.1111/bju.12342

M3 - SCORING: Journal article

C2 - 24053552

VL - 114

SP - 503

EP - 510

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 4

ER -