Prognosis of mild cognitive impairment in general practice: results of the German AgeCoDe study
Standard
Prognosis of mild cognitive impairment in general practice: results of the German AgeCoDe study. / Kaduszkiewicz, Hanna; Eisele, Marion; Wiese, Birgitt; Prokein, Jana; Luppa, Melanie; Luck, Tobias; Jessen, Frank; Bickel, Horst; Mösch, Edelgard; Pentzek, Michael; Fuchs, Angela; Eifflaender-Gorfer, Sandra; Weyerer, Siegfried; König, Hans-Helmut; Brettschneider, Christian; Bussche van den, Hendrik; Maier, Wolfgang; Scherer, Martin; Riedel-Heller, Steffi G; Study on Aging, Cognition, and Dementia in Primary Care Patients (AgeCoDe) Study Group.
in: ANN FAM MED, Jahrgang 12, Nr. 2, 13.03.2014, S. 158-65.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Prognosis of mild cognitive impairment in general practice: results of the German AgeCoDe study
AU - Kaduszkiewicz, Hanna
AU - Eisele, Marion
AU - Wiese, Birgitt
AU - Prokein, Jana
AU - Luppa, Melanie
AU - Luck, Tobias
AU - Jessen, Frank
AU - Bickel, Horst
AU - Mösch, Edelgard
AU - Pentzek, Michael
AU - Fuchs, Angela
AU - Eifflaender-Gorfer, Sandra
AU - Weyerer, Siegfried
AU - König, Hans-Helmut
AU - Brettschneider, Christian
AU - Bussche van den, Hendrik
AU - Maier, Wolfgang
AU - Scherer, Martin
AU - Riedel-Heller, Steffi G
AU - Study on Aging, Cognition, and Dementia in Primary Care Patients (AgeCoDe) Study Group
PY - 2014/3/13
Y1 - 2014/3/13
N2 - PURPOSE: The concept of mild cognitive impairment (MCI) has recently been introduced into the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as mild neurocognitive disorder, making it a formal diagnosis. We investigated the prognostic value of such a diagnosis and analyzed the determinants of the future course of MCI in the AgeCoDe study (German Study on Ageing, Cognition, and Dementia in Primary Care Patients).METHODS: We recruited 357 patients with MCI aged 75 years or older from primary care practices and conducted follow-up with interviews for 3 years. Depending on the course of impairment over time, the patients were retrospectively split into 4 groups representing remittent, fluctuating, stable, and progressive courses of MCI. We performed ordinal logistic regression analysis and classification and regression tree (CART) analysis.RESULTS: Overall, 41.5% of the patients had remission of symptoms with normal cognitive function 1.5 and 3 years later, 21.3% showed a fluctuating course, 14.8% had stable symptoms, and 22.4% had progression to dementia. Patients were at higher risk for advancing from one course to the next along this spectrum if they had symptoms of depression, impairment in more than 1 cognitive domain, or more severe cognitive impairment, or were older. The result on a test of the ability to learn and reproduce new material 10 minutes later was the best indicator at baseline for differentiating between remittent and progressive MCI. Symptoms of depression modified the prognosis.CONCLUSIONS: In primary care, about one-quarter of patients with MCI have progression to dementia within the next 3 years. Assessments of memory function and depressive symptoms are helpful in predicting a progressive vs a remittent course. When transferring the concept of MCI into clinical diagnostic algorithms (eg, DSM-5), however, we should not forget that three-quarters of patients with MCI stayed cognitively stable or even improved within 3 years. They should not be alarmed unnecessarily by receiving such a diagnosis.
AB - PURPOSE: The concept of mild cognitive impairment (MCI) has recently been introduced into the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) as mild neurocognitive disorder, making it a formal diagnosis. We investigated the prognostic value of such a diagnosis and analyzed the determinants of the future course of MCI in the AgeCoDe study (German Study on Ageing, Cognition, and Dementia in Primary Care Patients).METHODS: We recruited 357 patients with MCI aged 75 years or older from primary care practices and conducted follow-up with interviews for 3 years. Depending on the course of impairment over time, the patients were retrospectively split into 4 groups representing remittent, fluctuating, stable, and progressive courses of MCI. We performed ordinal logistic regression analysis and classification and regression tree (CART) analysis.RESULTS: Overall, 41.5% of the patients had remission of symptoms with normal cognitive function 1.5 and 3 years later, 21.3% showed a fluctuating course, 14.8% had stable symptoms, and 22.4% had progression to dementia. Patients were at higher risk for advancing from one course to the next along this spectrum if they had symptoms of depression, impairment in more than 1 cognitive domain, or more severe cognitive impairment, or were older. The result on a test of the ability to learn and reproduce new material 10 minutes later was the best indicator at baseline for differentiating between remittent and progressive MCI. Symptoms of depression modified the prognosis.CONCLUSIONS: In primary care, about one-quarter of patients with MCI have progression to dementia within the next 3 years. Assessments of memory function and depressive symptoms are helpful in predicting a progressive vs a remittent course. When transferring the concept of MCI into clinical diagnostic algorithms (eg, DSM-5), however, we should not forget that three-quarters of patients with MCI stayed cognitively stable or even improved within 3 years. They should not be alarmed unnecessarily by receiving such a diagnosis.
KW - Aged
KW - Aged, 80 and over
KW - Disease Progression
KW - Female
KW - General Practice
KW - Geriatric Assessment
KW - Germany
KW - Humans
KW - Male
KW - Mild Cognitive Impairment
KW - Prognosis
KW - Retrospective Studies
U2 - 10.1370/afm.1596
DO - 10.1370/afm.1596
M3 - SCORING: Journal article
C2 - 24615312
VL - 12
SP - 158
EP - 165
JO - ANN FAM MED
JF - ANN FAM MED
SN - 1544-1709
IS - 2
ER -