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Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.

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Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. / Pietro, Pilo Boyl; Alessia, Di Nardo; Mulle, Christophe; Sassoè-Pognetto, Marco; Panzanelli, Patrizia; Mele, Andrea; Kneussel, Matthias; Costantini, Vivian; Perlas, Emerald; Massimi, Marzia; Vara, Hugo; Giustetto, Maurizio; Witke, Walter.

in: EMBO J, Jahrgang 26, Nr. 12, 12, 2007, S. 2991-3002.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pietro, PB, Alessia, DN, Mulle, C, Sassoè-Pognetto, M, Panzanelli, P, Mele, A, Kneussel, M, Costantini, V, Perlas, E, Massimi, M, Vara, H, Giustetto, M & Witke, W 2007, 'Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.', EMBO J, Jg. 26, Nr. 12, 12, S. 2991-3002. <http://www.ncbi.nlm.nih.gov/pubmed/17541406?dopt=Citation>

APA

Pietro, P. B., Alessia, D. N., Mulle, C., Sassoè-Pognetto, M., Panzanelli, P., Mele, A., Kneussel, M., Costantini, V., Perlas, E., Massimi, M., Vara, H., Giustetto, M., & Witke, W. (2007). Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J, 26(12), 2991-3002. [12]. http://www.ncbi.nlm.nih.gov/pubmed/17541406?dopt=Citation

Vancouver

Pietro PB, Alessia DN, Mulle C, Sassoè-Pognetto M, Panzanelli P, Mele A et al. Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J. 2007;26(12):2991-3002. 12.

Bibtex

@article{9ef69e1cf1b547318b637a6d5b7ff3de,
title = "Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.",
abstract = "Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior.",
author = "Pietro, {Pilo Boyl} and Alessia, {Di Nardo} and Christophe Mulle and Marco Sasso{\`e}-Pognetto and Patrizia Panzanelli and Andrea Mele and Matthias Kneussel and Vivian Costantini and Emerald Perlas and Marzia Massimi and Hugo Vara and Maurizio Giustetto and Walter Witke",
year = "2007",
language = "Deutsch",
volume = "26",
pages = "2991--3002",
journal = "EMBO J",
issn = "0261-4189",
publisher = "NATURE PUBLISHING GROUP",
number = "12",

}

RIS

TY - JOUR

T1 - Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.

AU - Pietro, Pilo Boyl

AU - Alessia, Di Nardo

AU - Mulle, Christophe

AU - Sassoè-Pognetto, Marco

AU - Panzanelli, Patrizia

AU - Mele, Andrea

AU - Kneussel, Matthias

AU - Costantini, Vivian

AU - Perlas, Emerald

AU - Massimi, Marzia

AU - Vara, Hugo

AU - Giustetto, Maurizio

AU - Witke, Walter

PY - 2007

Y1 - 2007

N2 - Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior.

AB - Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior.

M3 - SCORING: Zeitschriftenaufsatz

VL - 26

SP - 2991

EP - 3002

JO - EMBO J

JF - EMBO J

SN - 0261-4189

IS - 12

M1 - 12

ER -