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Prion protein regulates glutamate-dependent lactate transport of astrocytes.

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Prion protein regulates glutamate-dependent lactate transport of astrocytes. / Kleene, Ralf; Loers, Gabriele; Langer, Julia; Frobert, Yveline; Buck, Friedrich; Schachner, Melitta.

in: J NEUROSCI, Jahrgang 27, Nr. 45, 45, 2007, S. 12331-12340.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kleene, R, Loers, G, Langer, J, Frobert, Y, Buck, F & Schachner, M 2007, 'Prion protein regulates glutamate-dependent lactate transport of astrocytes.', J NEUROSCI, Jg. 27, Nr. 45, 45, S. 12331-12340. <http://www.ncbi.nlm.nih.gov/pubmed/17989297?dopt=Citation>

APA

Kleene, R., Loers, G., Langer, J., Frobert, Y., Buck, F., & Schachner, M. (2007). Prion protein regulates glutamate-dependent lactate transport of astrocytes. J NEUROSCI, 27(45), 12331-12340. [45]. http://www.ncbi.nlm.nih.gov/pubmed/17989297?dopt=Citation

Vancouver

Kleene R, Loers G, Langer J, Frobert Y, Buck F, Schachner M. Prion protein regulates glutamate-dependent lactate transport of astrocytes. J NEUROSCI. 2007;27(45):12331-12340. 45.

Bibtex

@article{c64fcc4852aa4267b035e0f93c874eba,
title = "Prion protein regulates glutamate-dependent lactate transport of astrocytes.",
abstract = "Prion-related protein (PrP) is a neural cell adhesion molecule involved in neurite outgrowth, neuronal survival, and synaptic function. In search of novel binding partners for PrP, we identified the alpha2/beta2-Na+/K+-ATPase and showed that this astroglial ATPase interacts directly with the immunoglobulin superfamily adhesion molecule basigin. In cultured astrocytes, PrP is involved in regulating lactate transport via the astroglial monocarboxylate transporter 1 (MCT1) and in conjunction with alpha2/beta2-ATPase and basigin. Lactate transport via MCT1 is glutamate dependent and regulated by glutamate receptor 2 (GluR2)-containing AMPA receptors with which PrP interacts. The functional interplay between PrP, GluR2, alpha2/beta2-ATPase, basigin, and MCT1 in regulating lactate transport of astrocytes may be functional in the metabolic cross talk between astrocytes and neurons, most likely under stress.",
author = "Ralf Kleene and Gabriele Loers and Julia Langer and Yveline Frobert and Friedrich Buck and Melitta Schachner",
year = "2007",
language = "Deutsch",
volume = "27",
pages = "12331--12340",
journal = "J NEUROSCI",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "45",

}

RIS

TY - JOUR

T1 - Prion protein regulates glutamate-dependent lactate transport of astrocytes.

AU - Kleene, Ralf

AU - Loers, Gabriele

AU - Langer, Julia

AU - Frobert, Yveline

AU - Buck, Friedrich

AU - Schachner, Melitta

PY - 2007

Y1 - 2007

N2 - Prion-related protein (PrP) is a neural cell adhesion molecule involved in neurite outgrowth, neuronal survival, and synaptic function. In search of novel binding partners for PrP, we identified the alpha2/beta2-Na+/K+-ATPase and showed that this astroglial ATPase interacts directly with the immunoglobulin superfamily adhesion molecule basigin. In cultured astrocytes, PrP is involved in regulating lactate transport via the astroglial monocarboxylate transporter 1 (MCT1) and in conjunction with alpha2/beta2-ATPase and basigin. Lactate transport via MCT1 is glutamate dependent and regulated by glutamate receptor 2 (GluR2)-containing AMPA receptors with which PrP interacts. The functional interplay between PrP, GluR2, alpha2/beta2-ATPase, basigin, and MCT1 in regulating lactate transport of astrocytes may be functional in the metabolic cross talk between astrocytes and neurons, most likely under stress.

AB - Prion-related protein (PrP) is a neural cell adhesion molecule involved in neurite outgrowth, neuronal survival, and synaptic function. In search of novel binding partners for PrP, we identified the alpha2/beta2-Na+/K+-ATPase and showed that this astroglial ATPase interacts directly with the immunoglobulin superfamily adhesion molecule basigin. In cultured astrocytes, PrP is involved in regulating lactate transport via the astroglial monocarboxylate transporter 1 (MCT1) and in conjunction with alpha2/beta2-ATPase and basigin. Lactate transport via MCT1 is glutamate dependent and regulated by glutamate receptor 2 (GluR2)-containing AMPA receptors with which PrP interacts. The functional interplay between PrP, GluR2, alpha2/beta2-ATPase, basigin, and MCT1 in regulating lactate transport of astrocytes may be functional in the metabolic cross talk between astrocytes and neurons, most likely under stress.

M3 - SCORING: Zeitschriftenaufsatz

VL - 27

SP - 12331

EP - 12340

JO - J NEUROSCI

JF - J NEUROSCI

SN - 0270-6474

IS - 45

M1 - 45

ER -