Primordial GATA6 macrophages function as extravascular platelets in sterile injury

J Zindel; M Peiseler; M Hossain; C Deppermann; W Y Lee; B Haenni; B Zuber; J F Deniset; B G J Surewaard; D Candinas; P Kubes

doi:10.1126/science.abe0595

Primordial GATA6 macrophages function as extravascular platelets in sterile injury

Standard

Primordial GATA6 macrophages function as extravascular platelets in sterile injury. / Zindel, J; Peiseler, M; Hossain, M; Deppermann, C; Lee, W Y; Haenni, B; Zuber, B; Deniset, J F; Surewaard, B G J; Candinas, D; Kubes, P.

in: SCIENCE, Jahrgang 371, Nr. 6533, 05.03.2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zindel, J, Peiseler, M, Hossain, M, Deppermann, C, Lee, WY, Haenni, B, Zuber, B, Deniset, JF, Surewaard, BGJ, Candinas, D & Kubes, P 2021, 'Primordial GATA6 macrophages function as extravascular platelets in sterile injury', SCIENCE, Jg. 371, Nr. 6533. https://doi.org/10.1126/science.abe0595

APA

Zindel, J., Peiseler, M., Hossain, M., Deppermann, C., Lee, W. Y., Haenni, B., Zuber, B., Deniset, J. F., Surewaard, B. G. J., Candinas, D., & Kubes, P. (2021). Primordial GATA6 macrophages function as extravascular platelets in sterile injury. SCIENCE, 371(6533). https://doi.org/10.1126/science.abe0595

Vancouver

Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B et al. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. SCIENCE. 2021 Mär 5;371(6533). https://doi.org/10.1126/science.abe0595

Bibtex

@article{407e80aceda343f481cc47bb40df7850,

title = "Primordial GATA6 macrophages function as extravascular platelets in sterile injury",

abstract = "Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.",

author = "J Zindel and M Peiseler and M Hossain and C Deppermann and Lee, {W Y} and B Haenni and B Zuber and Deniset, {J F} and Surewaard, {B G J} and D Candinas and P Kubes",

note = "Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2021",

month = mar,

day = "5",

doi = "10.1126/science.abe0595",

language = "English",

volume = "371",

journal = "SCIENCE",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6533",

}

RIS

TY - JOUR

T1 - Primordial GATA6 macrophages function as extravascular platelets in sterile injury

AU - Zindel, J

AU - Peiseler, M

AU - Hossain, M

AU - Deppermann, C

AU - Lee, W Y

AU - Haenni, B

AU - Zuber, B

AU - Deniset, J F

AU - Surewaard, B G J

AU - Candinas, D

AU - Kubes, P

PY - 2021/3/5

Y1 - 2021/3/5

N2 - Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.

AB - Most multicellular organisms have a major body cavity that harbors immune cells. In primordial species such as purple sea urchins, these cells perform phagocytic functions but are also crucial in repairing injuries. In mammals, the peritoneal cavity contains large numbers of resident GATA6+ macrophages, which may function similarly. However, it is unclear how cavity macrophages suspended in the fluid phase (peritoneal fluid) identify and migrate toward injuries. In this study, we used intravital microscopy to show that cavity macrophages in fluid rapidly form thrombus-like structures in response to injury by means of primordial scavenger receptor cysteine-rich domains. Aggregates of cavity macrophages physically sealed injuries and promoted rapid repair of focal lesions. In iatrogenic surgical situations, these cavity macrophages formed extensive aggregates that promoted the growth of intra-abdominal scar tissue known as peritoneal adhesions.

U2 - 10.1126/science.abe0595

DO - 10.1126/science.abe0595

M3 - SCORING: Journal article

C2 - 33674464

VL - 371

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6533

ER -