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Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry

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Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry. / Schramm, Christoph; Bubenheim, Michael; Adam, René; Karam, Vincent; Buckels, John; O'Grady, John G; Jamieson, Neville; Pollard, Stephen; Neuhaus, Peter; Manns, Michael M; Porte, Robert; Castaing, Denis; Paul, Andreas; Traynor, Oscar; Garden, James; Friman, Styrbjörn; Ericzon, Bo-Goran; Fischer, Lutz; Vitko, Stefan; Krawczyk, Marek; Metselaar, Herold J; Foss, Aksel; Kilic, Murat; Rolles, Keith; Burra, Patrizia; Rogiers, Xavier; Lohse, Ansgar W; European Liver Intestine Transplant Association.

in: LIVER TRANSPLANT, Jahrgang 16, Nr. 4, 4, 04.2010, S. 461-469.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schramm, C, Bubenheim, M, Adam, R, Karam, V, Buckels, J, O'Grady, JG, Jamieson, N, Pollard, S, Neuhaus, P, Manns, MM, Porte, R, Castaing, D, Paul, A, Traynor, O, Garden, J, Friman, S, Ericzon, B-G, Fischer, L, Vitko, S, Krawczyk, M, Metselaar, HJ, Foss, A, Kilic, M, Rolles, K, Burra, P, Rogiers, X, Lohse, AW & European Liver Intestine Transplant Association 2010, 'Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry', LIVER TRANSPLANT, Jg. 16, Nr. 4, 4, S. 461-469. https://doi.org/10.1002/lt.22018

APA

Schramm, C., Bubenheim, M., Adam, R., Karam, V., Buckels, J., O'Grady, J. G., Jamieson, N., Pollard, S., Neuhaus, P., Manns, M. M., Porte, R., Castaing, D., Paul, A., Traynor, O., Garden, J., Friman, S., Ericzon, B-G., Fischer, L., Vitko, S., ... European Liver Intestine Transplant Association (2010). Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry. LIVER TRANSPLANT, 16(4), 461-469. [4]. https://doi.org/10.1002/lt.22018

Vancouver

Schramm C, Bubenheim M, Adam R, Karam V, Buckels J, O'Grady JG et al. Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry. LIVER TRANSPLANT. 2010 Apr;16(4):461-469. 4. https://doi.org/10.1002/lt.22018

Bibtex

@article{a6f9d8cce7c34e0eaf5cf4d707399780,
title = "Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry",
abstract = "The principal aim of this study was to compare the probability of and potential risk factors for death and graft loss after primary adult and pediatric liver transplantation in patients undergoing transplantation for autoimmune hepatitis (AIH) to those in patients undergoing transplantation for primary biliary cirrhosis (PBC; used as the reference group) or alcoholic cirrhosis (used as an example of a nonautoimmune liver disease). The 5-year survival of patients undergoing transplantation for AIH (n = 827) was 0.73 [95% confidence interval (CI) = 0.67-0.77]. This was similar to that of patients undergoing transplantation for alcoholic cirrhosis (0.74, 95% CI = 0.72-0.76, n = 6424) but significantly worse than that of patients undergoing transplantation for PBC (0.83, 95% CI = 0.80-0.85, n = 1588). Fatal infectious complications occurred at an increased rate in patients with AIH (hazard ratio = 1.8, P = 0.002 with PBC as the reference). The outcome of pediatric AIH patients was similar to that of adult patients undergoing transplantation up to the age of 50 years. However, the survival of AIH patients undergoing transplantation beyond the age of 50 years (0.61 at 5 years, 95% CI = 0.51-0.70) was significantly reduced in comparison with the survival of young adult AIH patients (0.78 at 18-34 years, 95% CI = 0.70-0.86) and in comparison with the survival of patients of the same age group with PBC or alcoholic cirrhosis. In conclusion, age significantly affects patient survival after liver transplantation for AIH. The increased risk of dying of infectious complications in the early postoperative period, especially above the age of 50 years, should be acknowledged in the management of AIH patients with advanced-stage liver disease who are listed for liver transplantation. It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database.",
keywords = "Adolescent, Adult, Europe, Female, Hepatitis, Autoimmune, Humans, Ischemia, Liver, Liver Transplantation, Male, Middle Aged, Registries, Risk Factors, Sex Factors, Treatment Outcome, Comparative Study, Journal Article",
author = "Christoph Schramm and Michael Bubenheim and Ren{\'e} Adam and Vincent Karam and John Buckels and O'Grady, {John G} and Neville Jamieson and Stephen Pollard and Peter Neuhaus and Manns, {Michael M} and Robert Porte and Denis Castaing and Andreas Paul and Oscar Traynor and James Garden and Styrbj{\"o}rn Friman and Bo-Goran Ericzon and Lutz Fischer and Stefan Vitko and Marek Krawczyk and Metselaar, {Herold J} and Aksel Foss and Murat Kilic and Keith Rolles and Patrizia Burra and Xavier Rogiers and Lohse, {Ansgar W} and {European Liver Intestine Transplant Association}",
note = "(c) 2010 AASLD.",
year = "2010",
month = apr,
doi = "10.1002/lt.22018",
language = "English",
volume = "16",
pages = "461--469",
journal = "LIVER TRANSPLANT",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Primary liver transplantation for autoimmune Hepatitis: A comparative analysis of the European Liver Transplant Registry

AU - Schramm, Christoph

AU - Bubenheim, Michael

AU - Adam, René

AU - Karam, Vincent

AU - Buckels, John

AU - O'Grady, John G

AU - Jamieson, Neville

AU - Pollard, Stephen

AU - Neuhaus, Peter

AU - Manns, Michael M

AU - Porte, Robert

AU - Castaing, Denis

AU - Paul, Andreas

AU - Traynor, Oscar

AU - Garden, James

AU - Friman, Styrbjörn

AU - Ericzon, Bo-Goran

AU - Fischer, Lutz

AU - Vitko, Stefan

AU - Krawczyk, Marek

AU - Metselaar, Herold J

AU - Foss, Aksel

AU - Kilic, Murat

AU - Rolles, Keith

AU - Burra, Patrizia

AU - Rogiers, Xavier

AU - Lohse, Ansgar W

AU - European Liver Intestine Transplant Association

N1 - (c) 2010 AASLD.

PY - 2010/4

Y1 - 2010/4

N2 - The principal aim of this study was to compare the probability of and potential risk factors for death and graft loss after primary adult and pediatric liver transplantation in patients undergoing transplantation for autoimmune hepatitis (AIH) to those in patients undergoing transplantation for primary biliary cirrhosis (PBC; used as the reference group) or alcoholic cirrhosis (used as an example of a nonautoimmune liver disease). The 5-year survival of patients undergoing transplantation for AIH (n = 827) was 0.73 [95% confidence interval (CI) = 0.67-0.77]. This was similar to that of patients undergoing transplantation for alcoholic cirrhosis (0.74, 95% CI = 0.72-0.76, n = 6424) but significantly worse than that of patients undergoing transplantation for PBC (0.83, 95% CI = 0.80-0.85, n = 1588). Fatal infectious complications occurred at an increased rate in patients with AIH (hazard ratio = 1.8, P = 0.002 with PBC as the reference). The outcome of pediatric AIH patients was similar to that of adult patients undergoing transplantation up to the age of 50 years. However, the survival of AIH patients undergoing transplantation beyond the age of 50 years (0.61 at 5 years, 95% CI = 0.51-0.70) was significantly reduced in comparison with the survival of young adult AIH patients (0.78 at 18-34 years, 95% CI = 0.70-0.86) and in comparison with the survival of patients of the same age group with PBC or alcoholic cirrhosis. In conclusion, age significantly affects patient survival after liver transplantation for AIH. The increased risk of dying of infectious complications in the early postoperative period, especially above the age of 50 years, should be acknowledged in the management of AIH patients with advanced-stage liver disease who are listed for liver transplantation. It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database.

AB - The principal aim of this study was to compare the probability of and potential risk factors for death and graft loss after primary adult and pediatric liver transplantation in patients undergoing transplantation for autoimmune hepatitis (AIH) to those in patients undergoing transplantation for primary biliary cirrhosis (PBC; used as the reference group) or alcoholic cirrhosis (used as an example of a nonautoimmune liver disease). The 5-year survival of patients undergoing transplantation for AIH (n = 827) was 0.73 [95% confidence interval (CI) = 0.67-0.77]. This was similar to that of patients undergoing transplantation for alcoholic cirrhosis (0.74, 95% CI = 0.72-0.76, n = 6424) but significantly worse than that of patients undergoing transplantation for PBC (0.83, 95% CI = 0.80-0.85, n = 1588). Fatal infectious complications occurred at an increased rate in patients with AIH (hazard ratio = 1.8, P = 0.002 with PBC as the reference). The outcome of pediatric AIH patients was similar to that of adult patients undergoing transplantation up to the age of 50 years. However, the survival of AIH patients undergoing transplantation beyond the age of 50 years (0.61 at 5 years, 95% CI = 0.51-0.70) was significantly reduced in comparison with the survival of young adult AIH patients (0.78 at 18-34 years, 95% CI = 0.70-0.86) and in comparison with the survival of patients of the same age group with PBC or alcoholic cirrhosis. In conclusion, age significantly affects patient survival after liver transplantation for AIH. The increased risk of dying of infectious complications in the early postoperative period, especially above the age of 50 years, should be acknowledged in the management of AIH patients with advanced-stage liver disease who are listed for liver transplantation. It should be noted that not all risk factors relevant to patient and graft survival could be analyzed with the European Liver Transplant Registry database.

KW - Adolescent

KW - Adult

KW - Europe

KW - Female

KW - Hepatitis, Autoimmune

KW - Humans

KW - Ischemia

KW - Liver

KW - Liver Transplantation

KW - Male

KW - Middle Aged

KW - Registries

KW - Risk Factors

KW - Sex Factors

KW - Treatment Outcome

KW - Comparative Study

KW - Journal Article

U2 - 10.1002/lt.22018

DO - 10.1002/lt.22018

M3 - SCORING: Journal article

C2 - 20373456

VL - 16

SP - 461

EP - 469

JO - LIVER TRANSPLANT

JF - LIVER TRANSPLANT

SN - 1527-6465

IS - 4

M1 - 4

ER -