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Primary decidual zone formation requires Scribble for pregnancy success in mice

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Primary decidual zone formation requires Scribble for pregnancy success in mice. / Yuan, Jia; Aikawa, Shizu; Deng, Wenbo; Bartos, Amanda; Walz, Gerd; Grahammer, Florian; Huber, Tobias B; Sun, Xiaofei; Dey, Sudhansu K.

in: NAT COMMUN, Jahrgang 10, Nr. 1, 28.11.2019, S. 5425.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Yuan, J, Aikawa, S, Deng, W, Bartos, A, Walz, G, Grahammer, F, Huber, TB, Sun, X & Dey, SK 2019, 'Primary decidual zone formation requires Scribble for pregnancy success in mice', NAT COMMUN, Jg. 10, Nr. 1, S. 5425. https://doi.org/10.1038/s41467-019-13489-4

APA

Yuan, J., Aikawa, S., Deng, W., Bartos, A., Walz, G., Grahammer, F., Huber, T. B., Sun, X., & Dey, S. K. (2019). Primary decidual zone formation requires Scribble for pregnancy success in mice. NAT COMMUN, 10(1), 5425. https://doi.org/10.1038/s41467-019-13489-4

Vancouver

Yuan J, Aikawa S, Deng W, Bartos A, Walz G, Grahammer F et al. Primary decidual zone formation requires Scribble for pregnancy success in mice. NAT COMMUN. 2019 Nov 28;10(1):5425. https://doi.org/10.1038/s41467-019-13489-4

Bibtex

@article{9130f37cac2a4d19b6084e6ffb6fb329,
title = "Primary decidual zone formation requires Scribble for pregnancy success in mice",
abstract = "Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in stromal cells around the implantation chamber following implantation. Stromal cells transform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (crypt). The PDZ creates a permeability barrier around the crypt restricting immune cells and harmful agents from maternal circulation to protect embryonic health. The mechanism underlying PDZ formation is not yet known. We found that uterine deletion of Scrib by a Pgr-Cre driver leads to defective PDZ formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affect PDZ formation and pregnancy success. These findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, potentially involving ZO-1 and Hippo signaling.",
author = "Jia Yuan and Shizu Aikawa and Wenbo Deng and Amanda Bartos and Gerd Walz and Florian Grahammer and Huber, {Tobias B} and Xiaofei Sun and Dey, {Sudhansu K}",
year = "2019",
month = nov,
day = "28",
doi = "10.1038/s41467-019-13489-4",
language = "English",
volume = "10",
pages = "5425",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Primary decidual zone formation requires Scribble for pregnancy success in mice

AU - Yuan, Jia

AU - Aikawa, Shizu

AU - Deng, Wenbo

AU - Bartos, Amanda

AU - Walz, Gerd

AU - Grahammer, Florian

AU - Huber, Tobias B

AU - Sun, Xiaofei

AU - Dey, Sudhansu K

PY - 2019/11/28

Y1 - 2019/11/28

N2 - Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in stromal cells around the implantation chamber following implantation. Stromal cells transform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (crypt). The PDZ creates a permeability barrier around the crypt restricting immune cells and harmful agents from maternal circulation to protect embryonic health. The mechanism underlying PDZ formation is not yet known. We found that uterine deletion of Scrib by a Pgr-Cre driver leads to defective PDZ formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affect PDZ formation and pregnancy success. These findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, potentially involving ZO-1 and Hippo signaling.

AB - Scribble (Scrib) is a scaffold protein with multifunctional roles in PCP, tight junction and Hippo signaling. This study shows that Scrib is expressed in stromal cells around the implantation chamber following implantation. Stromal cells transform into epithelial-like cells to form the avascular primary decidual zone (PDZ) around the implantation chamber (crypt). The PDZ creates a permeability barrier around the crypt restricting immune cells and harmful agents from maternal circulation to protect embryonic health. The mechanism underlying PDZ formation is not yet known. We found that uterine deletion of Scrib by a Pgr-Cre driver leads to defective PDZ formation and implantation chamber (crypt) formation, compromising pregnancy success. Interestingly, epithelial-specific Scrib deletion by a lactoferrin-Cre (Ltf-Cre) driver does not adversely affect PDZ formation and pregnancy success. These findings provide evidence for a previously unknown function of stromal Scrib in PDZ formation, potentially involving ZO-1 and Hippo signaling.

U2 - 10.1038/s41467-019-13489-4

DO - 10.1038/s41467-019-13489-4

M3 - SCORING: Journal article

C2 - 31780662

VL - 10

SP - 5425

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -