Primary Angiitis of the Central Nervous System
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Primary Angiitis of the Central Nervous System : New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid. / Deb-Chatterji, Milani; Schuster, Simon; Haeussler, Vivien; Gerloff, Christian; Thomalla, Götz; Magnus, Tim.
in: FRONT NEUROL, Jahrgang 10, 06.06.2019, S. 568.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Primary Angiitis of the Central Nervous System
T2 - New Potential Imaging Techniques and Biomarkers in Blood and Cerebrospinal Fluid
AU - Deb-Chatterji, Milani
AU - Schuster, Simon
AU - Haeussler, Vivien
AU - Gerloff, Christian
AU - Thomalla, Götz
AU - Magnus, Tim
PY - 2019/6/6
Y1 - 2019/6/6
N2 - Primary angiitis of the central nervous system (PACNS) is an inflammatory brain disease affecting the medium and small vessels of the CNS. Although recent data of patients with PACNS have advanced the understanding of the disease, the diagnosis remains challenging. Clinical presentation of PACNS is broad and unspecific and the majority of the diagnostic approaches are hallmarked by a low specificity. Thus, PACNS is commonly misdiagnosed. In addition, due to its potential aggressive course which may be altered by an adequate immunosuppressive treatment, delineation from other vasculopathies and PACNS mimics is crucial. New diagnostic tools and biomarkers which increase specificity and facilitate the diagnosis for patients with suspected PACNS are highly desirable. This short review summarizes the current procedures within the diagnostic process and aims to illustrate its difficulties and challenges. Furthermore, it highlights emerging biomarkers in the cerebrospinal fluid and peripheral venous blood as well as novel potential imaging tools that may corroborate the diagnosis. With new imaging techniques and a panel of biomarkers the certainty of the diagnosis may be increased and diagnostic processes more accelerated in the future.
AB - Primary angiitis of the central nervous system (PACNS) is an inflammatory brain disease affecting the medium and small vessels of the CNS. Although recent data of patients with PACNS have advanced the understanding of the disease, the diagnosis remains challenging. Clinical presentation of PACNS is broad and unspecific and the majority of the diagnostic approaches are hallmarked by a low specificity. Thus, PACNS is commonly misdiagnosed. In addition, due to its potential aggressive course which may be altered by an adequate immunosuppressive treatment, delineation from other vasculopathies and PACNS mimics is crucial. New diagnostic tools and biomarkers which increase specificity and facilitate the diagnosis for patients with suspected PACNS are highly desirable. This short review summarizes the current procedures within the diagnostic process and aims to illustrate its difficulties and challenges. Furthermore, it highlights emerging biomarkers in the cerebrospinal fluid and peripheral venous blood as well as novel potential imaging tools that may corroborate the diagnosis. With new imaging techniques and a panel of biomarkers the certainty of the diagnosis may be increased and diagnostic processes more accelerated in the future.
U2 - 10.3389/fneur.2019.00568
DO - 10.3389/fneur.2019.00568
M3 - SCORING: Review article
C2 - 31244749
VL - 10
SP - 568
JO - FRONT NEUROL
JF - FRONT NEUROL
SN - 1664-2295
ER -
