Prevention and treatment of relapse after stem cell transplantation by cellular therapies
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Prevention and treatment of relapse after stem cell transplantation by cellular therapies. / Falkenburg, Fred; Ruggiero, Eliana; Bonini, Chaira; Porter, David; Miller, Jeff; Malard, Floran; Mohty, Mohamad; Kröger, Nicolaus; Kolb, Hans Jochem.
in: BONE MARROW TRANSPL, Jahrgang 54, Nr. 1, 01.2019, S. 26-34.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Prevention and treatment of relapse after stem cell transplantation by cellular therapies
AU - Falkenburg, Fred
AU - Ruggiero, Eliana
AU - Bonini, Chaira
AU - Porter, David
AU - Miller, Jeff
AU - Malard, Floran
AU - Mohty, Mohamad
AU - Kröger, Nicolaus
AU - Kolb, Hans Jochem
PY - 2019/1
Y1 - 2019/1
N2 - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.
AB - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.
KW - Journal Article
KW - Stem Cell Transplantation
KW - Recurrence
KW - Allografts
KW - Immunotherapy, Adoptive
KW - Humans
KW - Killer Cells, Natural/transplantation
KW - T-Lymphocytes/transplantation
U2 - 10.1038/s41409-018-0227-0
DO - 10.1038/s41409-018-0227-0
M3 - SCORING: Review article
C2 - 29795426
VL - 54
SP - 26
EP - 34
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 1
ER -