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Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.

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Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. / Fischer, Nicole; Hellwinkel, Olaf; Schulz, Claudia; Chun, Felix; Huland, Hartwig; Aepfelbacher, Martin; Schlomm, Thorsten.

in: J CLIN VIROL, Jahrgang 43, Nr. 3, 3, 2008, S. 277-283.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fischer, N, Hellwinkel, O, Schulz, C, Chun, F, Huland, H, Aepfelbacher, M & Schlomm, T 2008, 'Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.', J CLIN VIROL, Jg. 43, Nr. 3, 3, S. 277-283. <http://www.ncbi.nlm.nih.gov/pubmed/18823818?dopt=Citation>

APA

Fischer, N., Hellwinkel, O., Schulz, C., Chun, F., Huland, H., Aepfelbacher, M., & Schlomm, T. (2008). Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J CLIN VIROL, 43(3), 277-283. [3]. http://www.ncbi.nlm.nih.gov/pubmed/18823818?dopt=Citation

Vancouver

Fischer N, Hellwinkel O, Schulz C, Chun F, Huland H, Aepfelbacher M et al. Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J CLIN VIROL. 2008;43(3):277-283. 3.

Bibtex

@article{5cc6d1b8aef94e9b887e4c412ad234bb,
title = "Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.",
abstract = "BACKGROUND: We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection. Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele. OBJECTIVES: To determine the presence of XMRV in non-familial prostate cancer samples. STUDY DESIGN: RNA from prostate tissue was analyzed for XMRV using nested RT-PCR. In all samples, RNase L (R462Q) genotyping was performed using an allele-specific PCR. RESULTS: XMRV-specific sequences were detected in one of 105 tissue samples from non-familial prostate cancer patients and from one of 70 tissue samples from men without prostate cancer. The two XMRV-positive patients were wild type or heterozygous for the R462Q mutation and thus carried at least one fully functional RNase L allele. CONCLUSIONS: XMRV was rarely detected in non-familial prostate cancer samples from Northern European patients. The homozygous mutation R462Q (QQ) was significantly underrepresented (",
author = "Nicole Fischer and Olaf Hellwinkel and Claudia Schulz and Felix Chun and Hartwig Huland and Martin Aepfelbacher and Thorsten Schlomm",
year = "2008",
language = "Deutsch",
volume = "43",
pages = "277--283",
journal = "J CLIN VIROL",
issn = "1386-6532",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.

AU - Fischer, Nicole

AU - Hellwinkel, Olaf

AU - Schulz, Claudia

AU - Chun, Felix

AU - Huland, Hartwig

AU - Aepfelbacher, Martin

AU - Schlomm, Thorsten

PY - 2008

Y1 - 2008

N2 - BACKGROUND: We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection. Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele. OBJECTIVES: To determine the presence of XMRV in non-familial prostate cancer samples. STUDY DESIGN: RNA from prostate tissue was analyzed for XMRV using nested RT-PCR. In all samples, RNase L (R462Q) genotyping was performed using an allele-specific PCR. RESULTS: XMRV-specific sequences were detected in one of 105 tissue samples from non-familial prostate cancer patients and from one of 70 tissue samples from men without prostate cancer. The two XMRV-positive patients were wild type or heterozygous for the R462Q mutation and thus carried at least one fully functional RNase L allele. CONCLUSIONS: XMRV was rarely detected in non-familial prostate cancer samples from Northern European patients. The homozygous mutation R462Q (QQ) was significantly underrepresented (

AB - BACKGROUND: We previously identified a novel exogenous gammaretrovirus (xenotropic murine leukemia virus-related gammaretrovirus (XMRV)) using a pan-viral microarray. XMRV is the first MLV-related virus found in human infection. Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele. OBJECTIVES: To determine the presence of XMRV in non-familial prostate cancer samples. STUDY DESIGN: RNA from prostate tissue was analyzed for XMRV using nested RT-PCR. In all samples, RNase L (R462Q) genotyping was performed using an allele-specific PCR. RESULTS: XMRV-specific sequences were detected in one of 105 tissue samples from non-familial prostate cancer patients and from one of 70 tissue samples from men without prostate cancer. The two XMRV-positive patients were wild type or heterozygous for the R462Q mutation and thus carried at least one fully functional RNase L allele. CONCLUSIONS: XMRV was rarely detected in non-familial prostate cancer samples from Northern European patients. The homozygous mutation R462Q (QQ) was significantly underrepresented (

M3 - SCORING: Zeitschriftenaufsatz

VL - 43

SP - 277

EP - 283

JO - J CLIN VIROL

JF - J CLIN VIROL

SN - 1386-6532

IS - 3

M1 - 3

ER -