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Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series.

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Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series. / Isbarn, Hendrik; Ahyai, Sascha A; Chun, Felix; Budäus, Lars; Schlomm, Thorsten; Salomon, Georg; Zacharias, Mario; Erbersdobler, Andreas; Köllermann, Jens; Sauter, Guido; Huland, Hartwig; Graefen, Markus; Steuber, Thomas.

in: EUR UROL, Jahrgang 55, Nr. 2, 2, 2009, S. 394-401.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Isbarn, H, Ahyai, SA, Chun, F, Budäus, L, Schlomm, T, Salomon, G, Zacharias, M, Erbersdobler, A, Köllermann, J, Sauter, G, Huland, H, Graefen, M & Steuber, T 2009, 'Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series.', EUR UROL, Jg. 55, Nr. 2, 2, S. 394-401. <http://www.ncbi.nlm.nih.gov/pubmed/18718699?dopt=Citation>

APA

Isbarn, H., Ahyai, S. A., Chun, F., Budäus, L., Schlomm, T., Salomon, G., Zacharias, M., Erbersdobler, A., Köllermann, J., Sauter, G., Huland, H., Graefen, M., & Steuber, T. (2009). Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series. EUR UROL, 55(2), 394-401. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18718699?dopt=Citation

Vancouver

Isbarn H, Ahyai SA, Chun F, Budäus L, Schlomm T, Salomon G et al. Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series. EUR UROL. 2009;55(2):394-401. 2.

Bibtex

@article{644548f030634dc0a7d51810e4896624,
title = "Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series.",
abstract = "BACKGROUND: The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. OBJECTIVE: To assess the prevalence of a TGG in a contemporary, consecutive, single-centre RP series and its association with adverse pathology. DESIGN, SETTING, AND PARTICIPANTS: From January to August 2007, 800 eligible patients (no prior neoadjuvant hormonal therapy) underwent RP for clinically localised prostate cancer (pCA) in our institution. The presence of the third most prevalent Gleason pattern was documented, regardless of whether it was better or worse than the two predominant Gleason grades. MEASUREMENTS: The overall prevalence of a TGG was described. Uni- and multivariate logistic regression analyses tested the association between the presence of a TGG or=5% of the whole tumour volume and extracapsular extension (ECE), seminal vesicle invasion (SVI), positive surgical margins (PSM), and lymph node invasion (LNI). Subanalyses were performed to assess the impact of different TGGs at various Gleason scores. RESULTS AND LIMITATIONS: A TGG was reported in 180 RP specimens (22.5%). In univariate analysis, the presence of a TGG >/=5% was significantly associated with ECE, SVI, PSM, and LNI (por=5% showed an independent association with ECE and PSM (p",
author = "Hendrik Isbarn and Ahyai, {Sascha A} and Felix Chun and Lars Bud{\"a}us and Thorsten Schlomm and Georg Salomon and Mario Zacharias and Andreas Erbersdobler and Jens K{\"o}llermann and Guido Sauter and Hartwig Huland and Markus Graefen and Thomas Steuber",
year = "2009",
language = "Deutsch",
volume = "55",
pages = "394--401",
journal = "EUR UROL",
issn = "0302-2838",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Prevalence of a tertiary Gleason grade and its impact on adverse histopathologic parameters in a contemporary radical prostatectomy series.

AU - Isbarn, Hendrik

AU - Ahyai, Sascha A

AU - Chun, Felix

AU - Budäus, Lars

AU - Schlomm, Thorsten

AU - Salomon, Georg

AU - Zacharias, Mario

AU - Erbersdobler, Andreas

AU - Köllermann, Jens

AU - Sauter, Guido

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Steuber, Thomas

PY - 2009

Y1 - 2009

N2 - BACKGROUND: The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. OBJECTIVE: To assess the prevalence of a TGG in a contemporary, consecutive, single-centre RP series and its association with adverse pathology. DESIGN, SETTING, AND PARTICIPANTS: From January to August 2007, 800 eligible patients (no prior neoadjuvant hormonal therapy) underwent RP for clinically localised prostate cancer (pCA) in our institution. The presence of the third most prevalent Gleason pattern was documented, regardless of whether it was better or worse than the two predominant Gleason grades. MEASUREMENTS: The overall prevalence of a TGG was described. Uni- and multivariate logistic regression analyses tested the association between the presence of a TGG or=5% of the whole tumour volume and extracapsular extension (ECE), seminal vesicle invasion (SVI), positive surgical margins (PSM), and lymph node invasion (LNI). Subanalyses were performed to assess the impact of different TGGs at various Gleason scores. RESULTS AND LIMITATIONS: A TGG was reported in 180 RP specimens (22.5%). In univariate analysis, the presence of a TGG >/=5% was significantly associated with ECE, SVI, PSM, and LNI (por=5% showed an independent association with ECE and PSM (p

AB - BACKGROUND: The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. OBJECTIVE: To assess the prevalence of a TGG in a contemporary, consecutive, single-centre RP series and its association with adverse pathology. DESIGN, SETTING, AND PARTICIPANTS: From January to August 2007, 800 eligible patients (no prior neoadjuvant hormonal therapy) underwent RP for clinically localised prostate cancer (pCA) in our institution. The presence of the third most prevalent Gleason pattern was documented, regardless of whether it was better or worse than the two predominant Gleason grades. MEASUREMENTS: The overall prevalence of a TGG was described. Uni- and multivariate logistic regression analyses tested the association between the presence of a TGG or=5% of the whole tumour volume and extracapsular extension (ECE), seminal vesicle invasion (SVI), positive surgical margins (PSM), and lymph node invasion (LNI). Subanalyses were performed to assess the impact of different TGGs at various Gleason scores. RESULTS AND LIMITATIONS: A TGG was reported in 180 RP specimens (22.5%). In univariate analysis, the presence of a TGG >/=5% was significantly associated with ECE, SVI, PSM, and LNI (por=5% showed an independent association with ECE and PSM (p

M3 - SCORING: Zeitschriftenaufsatz

VL - 55

SP - 394

EP - 401

JO - EUR UROL

JF - EUR UROL

SN - 0302-2838

IS - 2

M1 - 2

ER -