Pretreatment tables predicting pathologic stage of locally advanced prostate cancer
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Pretreatment tables predicting pathologic stage of locally advanced prostate cancer. / Joniau, Steven; Spahn, Martin; Briganti, Alberto; Gandaglia, Giorgio; Tombal, Bertrand; Tosco, Lorenzo; Marchioro, Giansilvio; Hsu, Chao-Yu; Walz, Jochen; Kneitz, Burkhard; Bader, Pia; Frohneberg, Detlef; Tizzani, Alessandro; Graefen, Markus; van Cangh, Paul; Karnes, R Jeffrey; Montorsi, Francesco; van Poppel, Hein; Gontero, Paolo; European Multicenter Prostate Cancer Clinical and Translational Research group (EMPaCT).
in: EUR UROL, Jahrgang 67, Nr. 2, 01.02.2015, S. 319-25.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Pretreatment tables predicting pathologic stage of locally advanced prostate cancer
AU - Joniau, Steven
AU - Spahn, Martin
AU - Briganti, Alberto
AU - Gandaglia, Giorgio
AU - Tombal, Bertrand
AU - Tosco, Lorenzo
AU - Marchioro, Giansilvio
AU - Hsu, Chao-Yu
AU - Walz, Jochen
AU - Kneitz, Burkhard
AU - Bader, Pia
AU - Frohneberg, Detlef
AU - Tizzani, Alessandro
AU - Graefen, Markus
AU - van Cangh, Paul
AU - Karnes, R Jeffrey
AU - Montorsi, Francesco
AU - van Poppel, Hein
AU - Gontero, Paolo
AU - European Multicenter Prostate Cancer Clinical and Translational Research group (EMPaCT)
N1 - Copyright © 2014 European Association of Urology. Published by Elsevier B.V. All rights reserved.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - BACKGROUND: Pretreatment tables for the prediction of pathologic stage have been published and validated for localized prostate cancer (PCa). No such tables are available for locally advanced (cT3a) PCa.OBJECTIVE: To construct tables predicting pathologic outcome after radical prostatectomy (RP) for patients with cT3a PCa with the aim to help guide treatment decisions in clinical practice.DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter retrospective cohort study including 759 consecutive patients with cT3a PCa treated with RP between 1987 and 2010.INTERVENTION: Retropubic RP and pelvic lymphadenectomy.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Patients were divided into pretreatment prostate-specific antigen (PSA) and biopsy Gleason score (GS) subgroups. These parameters were used to construct tables predicting pathologic outcome and the presence of positive lymph nodes (LNs) after RP for cT3a PCa using ordinal logistic regression.RESULTS AND LIMITATIONS: In the model predicting pathologic outcome, the main effects of biopsy GS and pretreatment PSA were significant. A higher GS and/or higher PSA level was associated with a more unfavorable pathologic outcome. The validation procedure, using a repeated split-sample method, showed good predictive ability. Regression analysis also showed an increasing probability of positive LNs with increasing PSA levels and/or higher GS. Limitations of the study are the retrospective design and the long study period.CONCLUSIONS: These novel tables predict pathologic stage after RP for patients with cT3a PCa based on pretreatment PSA level and biopsy GS. They can be used to guide decision making in men with locally advanced PCa.PATIENT SUMMARY: Our study might provide physicians with a useful tool to predict pathologic stage in locally advanced prostate cancer that might help select patients who may need multimodal treatment.
AB - BACKGROUND: Pretreatment tables for the prediction of pathologic stage have been published and validated for localized prostate cancer (PCa). No such tables are available for locally advanced (cT3a) PCa.OBJECTIVE: To construct tables predicting pathologic outcome after radical prostatectomy (RP) for patients with cT3a PCa with the aim to help guide treatment decisions in clinical practice.DESIGN, SETTING, AND PARTICIPANTS: This was a multicenter retrospective cohort study including 759 consecutive patients with cT3a PCa treated with RP between 1987 and 2010.INTERVENTION: Retropubic RP and pelvic lymphadenectomy.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Patients were divided into pretreatment prostate-specific antigen (PSA) and biopsy Gleason score (GS) subgroups. These parameters were used to construct tables predicting pathologic outcome and the presence of positive lymph nodes (LNs) after RP for cT3a PCa using ordinal logistic regression.RESULTS AND LIMITATIONS: In the model predicting pathologic outcome, the main effects of biopsy GS and pretreatment PSA were significant. A higher GS and/or higher PSA level was associated with a more unfavorable pathologic outcome. The validation procedure, using a repeated split-sample method, showed good predictive ability. Regression analysis also showed an increasing probability of positive LNs with increasing PSA levels and/or higher GS. Limitations of the study are the retrospective design and the long study period.CONCLUSIONS: These novel tables predict pathologic stage after RP for patients with cT3a PCa based on pretreatment PSA level and biopsy GS. They can be used to guide decision making in men with locally advanced PCa.PATIENT SUMMARY: Our study might provide physicians with a useful tool to predict pathologic stage in locally advanced prostate cancer that might help select patients who may need multimodal treatment.
U2 - 10.1016/j.eururo.2014.03.013
DO - 10.1016/j.eururo.2014.03.013
M3 - SCORING: Journal article
C2 - 24684960
VL - 67
SP - 319
EP - 325
JO - EUR UROL
JF - EUR UROL
SN - 0302-2838
IS - 2
ER -