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Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina

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Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. / Haumann, Iris; Junghans, Dirk; Anstötz, Max; Frotscher, Michael.

in: PLOS ONE, Jahrgang 12, Nr. 2, 2017, S. e0172967.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Haumann, I, Junghans, D, Anstötz, M & Frotscher, M 2017, 'Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina', PLOS ONE, Jg. 12, Nr. 2, S. e0172967. https://doi.org/10.1371/journal.pone.0172967

APA

Haumann, I., Junghans, D., Anstötz, M., & Frotscher, M. (2017). Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. PLOS ONE, 12(2), e0172967. https://doi.org/10.1371/journal.pone.0172967

Vancouver

Haumann I, Junghans D, Anstötz M, Frotscher M. Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. PLOS ONE. 2017;12(2):e0172967. https://doi.org/10.1371/journal.pone.0172967

Bibtex

@article{953a4051d4f14f2cb74c8a02c19e25f9,
title = "Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina",
abstract = "Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.",
keywords = "Journal Article",
author = "Iris Haumann and Dirk Junghans and Max Anst{\"o}tz and Michael Frotscher",
year = "2017",
doi = "10.1371/journal.pone.0172967",
language = "English",
volume = "12",
pages = "e0172967",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina

AU - Haumann, Iris

AU - Junghans, Dirk

AU - Anstötz, Max

AU - Frotscher, Michael

PY - 2017

Y1 - 2017

N2 - Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

AB - Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

KW - Journal Article

U2 - 10.1371/journal.pone.0172967

DO - 10.1371/journal.pone.0172967

M3 - SCORING: Journal article

C2 - 28235022

VL - 12

SP - e0172967

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

ER -