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Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.

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Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes. / Rathmann, Silvia; Rajasalu, Tarvo; Rosinger, Silke; Schlosser, Michael; Eiermann, Thomas; Boehm, Bernhard O; Durinovic-Belló, Ivana.

in: ANN NY ACAD SCI, Jahrgang 1037, 2004, S. 22-25.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rathmann, S, Rajasalu, T, Rosinger, S, Schlosser, M, Eiermann, T, Boehm, BO & Durinovic-Belló, I 2004, 'Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.', ANN NY ACAD SCI, Jg. 1037, S. 22-25. <http://www.ncbi.nlm.nih.gov/pubmed/15699489?dopt=Citation>

APA

Rathmann, S., Rajasalu, T., Rosinger, S., Schlosser, M., Eiermann, T., Boehm, B. O., & Durinovic-Belló, I. (2004). Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes. ANN NY ACAD SCI, 1037, 22-25. http://www.ncbi.nlm.nih.gov/pubmed/15699489?dopt=Citation

Vancouver

Rathmann S, Rajasalu T, Rosinger S, Schlosser M, Eiermann T, Boehm BO et al. Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes. ANN NY ACAD SCI. 2004;1037:22-25.

Bibtex

@article{7b25501a12684f37a8965c952ec6472b,
title = "Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.",
abstract = "In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.",
author = "Silvia Rathmann and Tarvo Rajasalu and Silke Rosinger and Michael Schlosser and Thomas Eiermann and Boehm, {Bernhard O} and Ivana Durinovic-Bell{\'o}",
year = "2004",
language = "Deutsch",
volume = "1037",
pages = "22--25",
journal = "ANN NY ACAD SCI",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetes.

AU - Rathmann, Silvia

AU - Rajasalu, Tarvo

AU - Rosinger, Silke

AU - Schlosser, Michael

AU - Eiermann, Thomas

AU - Boehm, Bernhard O

AU - Durinovic-Belló, Ivana

PY - 2004

Y1 - 2004

N2 - In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.

AB - In animal models autoreactive CD8(+) T cells are crucial in the development of type 1 diabetes (T1D); however, their role in human T1D is still not known. To address the role of CD81 T cells we performed a pilot study by investigating CD8(+) T cell-mediated cytokine secretion after in vitro stimulation with 94 preproinsulin (PPI) peptides. We were able to show that CD8(+) T cells contribute to a strong IFNgamma reactivity against PPI in human T1D. Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development.

M3 - SCORING: Zeitschriftenaufsatz

VL - 1037

SP - 22

EP - 25

JO - ANN NY ACAD SCI

JF - ANN NY ACAD SCI

SN - 0077-8923

ER -