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Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy

Standard

Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy. / Gierth, M; Mayr, R; Aziz, A; Krieger, S; Wullich, B; Pycha, A; Lodde, M; Salvadori, U; Bründl, J; Fritsche, H M; Hofstädter, F; Pawlik, M T; Otto, W; May, M; Burger, M; Denzinger, S.

in: J CANCER RES CLIN, Jahrgang 141, Nr. 10, 10.2015, S. 1819-26.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gierth, M, Mayr, R, Aziz, A, Krieger, S, Wullich, B, Pycha, A, Lodde, M, Salvadori, U, Bründl, J, Fritsche, HM, Hofstädter, F, Pawlik, MT, Otto, W, May, M, Burger, M & Denzinger, S 2015, 'Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy', J CANCER RES CLIN, Jg. 141, Nr. 10, S. 1819-26. https://doi.org/10.1007/s00432-015-1957-7

APA

Gierth, M., Mayr, R., Aziz, A., Krieger, S., Wullich, B., Pycha, A., Lodde, M., Salvadori, U., Bründl, J., Fritsche, H. M., Hofstädter, F., Pawlik, M. T., Otto, W., May, M., Burger, M., & Denzinger, S. (2015). Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy. J CANCER RES CLIN, 141(10), 1819-26. https://doi.org/10.1007/s00432-015-1957-7

Vancouver

Gierth M, Mayr R, Aziz A, Krieger S, Wullich B, Pycha A et al. Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy. J CANCER RES CLIN. 2015 Okt;141(10):1819-26. https://doi.org/10.1007/s00432-015-1957-7

Bibtex

@article{1c498173ab194b408b31ecdbd27f7a78,
title = "Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy",
abstract = "PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss, whereas many patients are presenting with anemia preoperatively. To date, there is a lack of data addressing the impact of preoperative anemia (PA) on survival of patients undergoing RC for urothelial carcinoma of the bladder (UCB).METHODS: This retrospective multicenter study includes 684 patients with UCB undergoing RC with pelvic lymph node dissection. The median follow-up was 50 (IQR 29,78) months. Anemia was defined in line with the WHO classification (hemoglobin (Hb): male ≤13 g/dL, female ≤12 g/dL) and based on contemporary gender- and age-adjusted classification (Hb: white male aged <60 years: ≤13.7 g/dL; ≥60 years: ≤13.2 g/dL; white female of all ages ≤12.2 g/dL). Univariable and multivariable Cox regression analyses were used to assess the effects of PA on oncological outcomes.RESULTS: A total of 269 (39.3 %) and 302 (44.2 %) patients were anemic according to the WHO classification versus contemporary classification. Age, increased ECOG performance status, advanced tumor stages, lymph node metastasis, positive surgical margin and anemia were associated with disease recurrence (DR), cancer-specific mortality (CSM) and all-cause mortality (ACM). In multivariable analysis, anemia was an independent predictor of DR, CSM and ACM (WHO and/or contemporary classification). Blood transfusion was significantly associated with ACM in both classifications of anemia.CONCLUSIONS: PA is significantly associated with worse oncological outcome in patients undergoing RC. Based on the additional unfavorable influence of blood transfusion, this emphasizes the importance of early diagnosis and correction of anemia and implementation of alternative methods of blood volume management.",
keywords = "Aged, Anemia, Blood Transfusion, Cystectomy, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Neoplasm Recurrence, Local, Retrospective Studies, Treatment Outcome, Urinary Bladder Neoplasms, Journal Article",
author = "M Gierth and R Mayr and A Aziz and S Krieger and B Wullich and A Pycha and M Lodde and U Salvadori and J Br{\"u}ndl and Fritsche, {H M} and F Hofst{\"a}dter and Pawlik, {M T} and W Otto and M May and M Burger and S Denzinger",
year = "2015",
month = oct,
doi = "10.1007/s00432-015-1957-7",
language = "English",
volume = "141",
pages = "1819--26",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Preoperative anemia is associated with adverse outcome in patients with urothelial carcinoma of the bladder following radical cystectomy

AU - Gierth, M

AU - Mayr, R

AU - Aziz, A

AU - Krieger, S

AU - Wullich, B

AU - Pycha, A

AU - Lodde, M

AU - Salvadori, U

AU - Bründl, J

AU - Fritsche, H M

AU - Hofstädter, F

AU - Pawlik, M T

AU - Otto, W

AU - May, M

AU - Burger, M

AU - Denzinger, S

PY - 2015/10

Y1 - 2015/10

N2 - PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss, whereas many patients are presenting with anemia preoperatively. To date, there is a lack of data addressing the impact of preoperative anemia (PA) on survival of patients undergoing RC for urothelial carcinoma of the bladder (UCB).METHODS: This retrospective multicenter study includes 684 patients with UCB undergoing RC with pelvic lymph node dissection. The median follow-up was 50 (IQR 29,78) months. Anemia was defined in line with the WHO classification (hemoglobin (Hb): male ≤13 g/dL, female ≤12 g/dL) and based on contemporary gender- and age-adjusted classification (Hb: white male aged <60 years: ≤13.7 g/dL; ≥60 years: ≤13.2 g/dL; white female of all ages ≤12.2 g/dL). Univariable and multivariable Cox regression analyses were used to assess the effects of PA on oncological outcomes.RESULTS: A total of 269 (39.3 %) and 302 (44.2 %) patients were anemic according to the WHO classification versus contemporary classification. Age, increased ECOG performance status, advanced tumor stages, lymph node metastasis, positive surgical margin and anemia were associated with disease recurrence (DR), cancer-specific mortality (CSM) and all-cause mortality (ACM). In multivariable analysis, anemia was an independent predictor of DR, CSM and ACM (WHO and/or contemporary classification). Blood transfusion was significantly associated with ACM in both classifications of anemia.CONCLUSIONS: PA is significantly associated with worse oncological outcome in patients undergoing RC. Based on the additional unfavorable influence of blood transfusion, this emphasizes the importance of early diagnosis and correction of anemia and implementation of alternative methods of blood volume management.

AB - PURPOSE: Radical cystectomy (RC) can be associated with significant blood loss, whereas many patients are presenting with anemia preoperatively. To date, there is a lack of data addressing the impact of preoperative anemia (PA) on survival of patients undergoing RC for urothelial carcinoma of the bladder (UCB).METHODS: This retrospective multicenter study includes 684 patients with UCB undergoing RC with pelvic lymph node dissection. The median follow-up was 50 (IQR 29,78) months. Anemia was defined in line with the WHO classification (hemoglobin (Hb): male ≤13 g/dL, female ≤12 g/dL) and based on contemporary gender- and age-adjusted classification (Hb: white male aged <60 years: ≤13.7 g/dL; ≥60 years: ≤13.2 g/dL; white female of all ages ≤12.2 g/dL). Univariable and multivariable Cox regression analyses were used to assess the effects of PA on oncological outcomes.RESULTS: A total of 269 (39.3 %) and 302 (44.2 %) patients were anemic according to the WHO classification versus contemporary classification. Age, increased ECOG performance status, advanced tumor stages, lymph node metastasis, positive surgical margin and anemia were associated with disease recurrence (DR), cancer-specific mortality (CSM) and all-cause mortality (ACM). In multivariable analysis, anemia was an independent predictor of DR, CSM and ACM (WHO and/or contemporary classification). Blood transfusion was significantly associated with ACM in both classifications of anemia.CONCLUSIONS: PA is significantly associated with worse oncological outcome in patients undergoing RC. Based on the additional unfavorable influence of blood transfusion, this emphasizes the importance of early diagnosis and correction of anemia and implementation of alternative methods of blood volume management.

KW - Aged

KW - Anemia

KW - Blood Transfusion

KW - Cystectomy

KW - Female

KW - Humans

KW - Lymph Node Excision

KW - Lymphatic Metastasis

KW - Male

KW - Neoplasm Recurrence, Local

KW - Retrospective Studies

KW - Treatment Outcome

KW - Urinary Bladder Neoplasms

KW - Journal Article

U2 - 10.1007/s00432-015-1957-7

DO - 10.1007/s00432-015-1957-7

M3 - SCORING: Journal article

C2 - 25832016

VL - 141

SP - 1819

EP - 1826

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 10

ER -