Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina
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Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina. / Afiyatullov, Shamil Sh; Zhuravleva, Olesya I; Antonov, Alexandr S; Berdyshev, Dmitrii V; Pivkin, Mikhail V; Denisenko, Vladimir A; Popov, Roman S; Gerasimenko, Andrey V; von Amsberg, Gunhild; Dyshlovoy, Sergey A; Leshchenko, Elena V; Yurchenko, Anton N.
in: J ANTIBIOT, Jahrgang 71, Nr. 10, 10.2018, S. 846-853.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Prenylated indole alkaloids from co-culture of marine-derived fungi Aspergillus sulphureus and Isaria felina
AU - Afiyatullov, Shamil Sh
AU - Zhuravleva, Olesya I
AU - Antonov, Alexandr S
AU - Berdyshev, Dmitrii V
AU - Pivkin, Mikhail V
AU - Denisenko, Vladimir A
AU - Popov, Roman S
AU - Gerasimenko, Andrey V
AU - von Amsberg, Gunhild
AU - Dyshlovoy, Sergey A
AU - Leshchenko, Elena V
AU - Yurchenko, Anton N
PY - 2018/10
Y1 - 2018/10
N2 - Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.
AB - Five new prenylated indole alkaloids, 17-hydroxynotoamide D (1), 17-O-ethylnotoamide M (2), 10-O-acetylsclerotiamide (3), 10-O-ethylsclerotiamide (4), and 10-O-ethylnotoamide R (5) were isolated from a co-culture of marine-derived fungi Aspergillus sulphureus KMM 4640 and Isaria felina KMM 4639. The structures of 1-5 were determined by detailed analysis of spectroscopic data and by comparison with related known compounds. The absolute configurations of 1-5 were determined by time-dependent density functional theory (TD-DFT) calculations of ECD spectra. Compound 2 is able to inhibit the colony formation of human prostate cancer cells 22Rv1 at non-cytotoxic concentration of 10 μM.
KW - Journal Article
U2 - 10.1038/s41429-018-0072-9
DO - 10.1038/s41429-018-0072-9
M3 - SCORING: Journal article
C2 - 29884864
VL - 71
SP - 846
EP - 853
JO - J ANTIBIOT
JF - J ANTIBIOT
SN - 0021-8820
IS - 10
ER -